TEX26

protein-coding

testis expressed 26

Gene summary

Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Previous symbols:

C13orf26

MANE transcript

NM_152325.3

Inheritance

—

ClinVar variants

P:2U:56B:5

Top phenotype

Primary ciliary dyskinesia

gnomAD constraint

pLI —, LoF o/e 0.9

Max pathogenic AF

—

Genomic locus

chr13:30,932,656-30,975,500

External References & Databases

Ensembl (ENSG00000175664)

Transcript & Mutation Effects

hg38 • Region Span ~42.8 kb

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GenCC Phenotypes & Disease Associations

Curated gene-disease validity assertions and inheritance patterns

No GenCC data available for this gene.

ClinVar Associated Diseases & Phenotypes

Reported disease conditions connected to TEX26 variants in ClinVar

3 Conditions Cataloged

not specifiedTotal: 58

not providedTotal: 2

Primary ciliary dyskinesiaTotal: 2

ClinVar Variants & Pathogenicity by Type

Statistics based on transcript NM_152325.3. Only rare variants are included.

We include only reliable ClinVar variants with their consequences to MANE Select, MANE Plus Clinical transcripts, or transcripts with TSL equal to 1. Click a count to filter the variants table below.

Slight differences between displayed counts and ClinVar may occur due to a different transcript/consequence chosen by our variant effect predictor, or because we classify Benign/Likely benign as Likely benign and Pathogenic/Likely pathogenic as Likely pathogenic.

Effect	PathogenicP	Likely pathogenicLP	VUS	Likely benignLB	BenignB	Sum
synonymous				1 clinvar		1
missense			55 clinvar	4 clinvar		59
nonsense		2 clinvar				2
start loss						0
frameshift						0
splice donor/acceptor (+/-2bp)			1 clinvar			1
Total	0	2	56	5	0	63

Highest pathogenic variant AF is 0.0001239145

Loading ClinVar variants...

Transcript Catalog

Annotated transcript isoforms across RefSeq and Ensembl databases

Showing 4 of 24 transcripts

Transcript ID	Source	Protein ID	Coding Exons	MANE Status
NM_152325.3	RefSeq	NP_689538.1	7	MANE Select
ENST00000380473.8	Ensembl	ENSP00000369840.3	7	MANE Select
NM_001353388.2	RefSeq	NP_001340317.1	4	Standard
NM_001353389.2	RefSeq	NP_001340318.1	4	Standard

Gene Ontology (GO) Annotations & Pathways

Biological processes, molecular functions, cellular components and pathways

Cellular Component

cytoplasm

gnomAD Constraint

Source: gnomAD

Gene type: protein_coding
Transcript type: protein_coding
Transcript: ENST00000380473
Coding exons: 7
Length: 42800
Individuals with no LoFs: 54844
Homozygous LoFs: 15696
Heterozygous LoFs: 55207
Defined: 125747
p: 0.340

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible
Missense	-1.14	184	145	1.26	0.00000707	1896
Missense (PolyPhen)		57	42.911	1.3283		577
Synonymous	-1.41	64	51.1	1.25	0.00000247	514
Loss of Function	0.381	14	15.6	0.896	7.45e-7	189

Population LoF Frequency

Population	CAF	p-value	Status
African	0.085	0.084	notable
Latino/Admixed American	0.31	0.31	notable
Ashkenazi Jewish	0.40	0.40	notable
East Asian	0.30	0.30	notable
Finnish	0.40	0.40	notable
European (Non-Finnish)	0.38	0.37	notable
South Asian	0.37	0.37	notable
Other	0.37	0.37	notable

dbNSFP Gene Annotations

Source: dbNSFP

Intolerance Scores

RVIS EVS: 0.46
RVIS percentile EVS: 78.59

Essentials

Essential (CRISPR): N
Essential (CRISPR2): N
Essential (gene trap): N
Indispensability pred.: N
Indispensability score: 0.114

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	Medium	Medium	Medium
Primary Immunodeficiency	Medium	Medium	High
Cancer	Medium	Medium	Medium