TEX26

testis expressed 26

Basic information

Region (hg38): 13:30932656-30975500

Previous symbols: [ "C13orf26" ]

Links

ENSG00000175664 ∙ NCBI:122046 ∙ ∙ HGNC:28622 ∙ Uniprot:Q8N6G2 ∙ AlphaFold ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the TEX26 gene.

• not_specified (48 variants)
• not_provided (2 variants)

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the TEX26 gene is commonly pathogenic or not. These statistics are base on transcript: NM_000152325.3. Only rare variants are included in the table.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Effect	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous				1		1
missense			47	2		49
nonsense						0
start loss						0
frameshift						0
splice donor/acceptor (+/-2bp)						0
Total	0	0	47	3	0

GnomAD

Source: gnomAD

Gene	Type	Bio Type	Transcript	Coding Exons	Length
TEX26	protein_coding	protein_coding	ENST00000380473	7	42800

pLI Probability LOF Intolerant	pRec Probability LOF Recessive	Individuals with no LOFs	Individuals with Homozygous LOFs	Individuals with Heterozygous LOFs	Defined	p
3.14e-9	0.173	54844	15696	55207	125747	0.340

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible in Transcript
Missense	-1.14	184	145	1.26	0.00000707	1896
Missense in Polyphen		57	42.911	1.3283		577
Synonymous	-1.41	64	51.1	1.25	0.00000247	514
Loss of Function	0.381	14	15.6	0.896	7.45e-7	189

LoF frequencies by population

Ethnicity	Sum of pLOFs	p
African & African-American	0.397	0.397
Ashkenazi Jewish	0.401	0.399
East Asian	0.303	0.303
Finnish	0.402	0.401
European (Non-Finnish)	0.376	0.374
Middle Eastern	0.303	0.303
South Asian	0.370	0.368
Other	0.373	0.371

dbNSFP

Source: dbNSFP

Intolerance Scores

• rvis_EVS: 0.46
• rvis_percentile_EVS: 78.59

Haploinsufficiency Scores

• pHI: 0.0488
• hipred: N
• hipred_score: 0.180
• ghis: 0.385

Essentials

• essential_gene_CRISPR: N
• essential_gene_CRISPR2: N
• essential_gene_gene_trap: N
• gene_indispensability_pred: N
• gene_indispensability_score: 0.114

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	Medium	Medium	Medium
Primary Immunodeficiency	Medium	Medium	High
Cancer	Medium	Medium	Medium

Mouse Genome Informatics

• Gene name: Tex26

Gene ontology

• Cellular component: cytoplasm