TEX26

testis expressed 26

Basic information

Region (hg38): 13:30932655-30975500

Previous symbols: [ "C13orf26" ]

Links

ENSG00000175664 ∙ NCBI:122046 ∙ ∙ HGNC:28622 ∙ Uniprot:Q8N6G2 ∙ AlphaFold ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the TEX26 gene.

• Inborn genetic diseases (15 variants)
• not provided (2 variants)

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the TEX26 gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous				1		1
missense			14	2		16
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding						0
Total	0	0	14	3	0

Variants in TEX26

This is a list of pathogenic ClinVar variants found in the TEX26 region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
13-30932731-C-A		not specified	Uncertain significance (Dec 16, 2022)
13-30932754-C-T			Likely benign (Mar 01, 2023)
13-30939701-C-A		not specified	Uncertain significance (Aug 09, 2021)
13-30939726-A-G		not specified	Uncertain significance (Feb 28, 2023)
13-30952662-A-G		not specified	Uncertain significance (Jan 30, 2024)
13-30952667-G-A		not specified	Likely benign (Dec 01, 2022)
13-30952722-C-G		not specified	Uncertain significance (Jun 07, 2023)
13-30952739-T-A		not specified	Uncertain significance (Jul 09, 2021)
13-30952794-G-A		not specified	Uncertain significance (Jun 24, 2022)
13-30956949-C-T		not specified	Uncertain significance (Sep 22, 2022)
13-30956954-A-G		not specified	Uncertain significance (Nov 03, 2022)
13-30956963-G-A		not specified	Uncertain significance (Jan 16, 2024)
13-30956981-A-T		not specified	Uncertain significance (Jun 06, 2023)
13-30956994-C-T		not specified	Uncertain significance (Jul 19, 2023)
13-30956996-C-T		not specified	Uncertain significance (Apr 27, 2022)
13-30957012-T-C		not specified	Uncertain significance (Feb 16, 2023)
13-30966251-T-A		not specified	Uncertain significance (Oct 10, 2023)
13-30966257-G-C		not specified	Uncertain significance (Dec 12, 2023)
13-30966300-G-A		not specified	Uncertain significance (Nov 17, 2023)
13-30968931-G-T			Benign/Likely benign (Mar 01, 2023)
13-30968935-C-G		not specified	Uncertain significance (Jun 07, 2023)
13-30968945-A-T		not specified	Uncertain significance (Jan 16, 2024)
13-30968959-G-A		not specified	Uncertain significance (Aug 09, 2021)
13-30968993-A-G		not specified	Uncertain significance (Nov 30, 2022)
13-30969005-C-A		not specified	Uncertain significance (Feb 06, 2024)

GnomAD

Source: gnomAD

Gene	Type	Bio Type	Transcript	Coding Exons	Length
TEX26	protein_coding	protein_coding	ENST00000380473	7	42800

pLI Probability LOF Intolerant	pRec Probability LOF Recessive	Individuals with no LOFs	Individuals with Homozygous LOFs	Individuals with Heterozygous LOFs	Defined	p
3.14e-9	0.173	54844	15696	55207	125747	0.340

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible in Transcript
Missense	-1.14	184	145	1.26	0.00000707	1896
Missense in Polyphen		57	42.911	1.3283		577
Synonymous	-1.41	64	51.1	1.25	0.00000247	514
Loss of Function	0.381	14	15.6	0.896	7.45e-7	189

LoF frequencies by population

Ethnicity	Sum of pLOFs	p
African & African-American	0.397	0.397
Ashkenazi Jewish	0.401	0.399
East Asian	0.303	0.303
Finnish	0.402	0.401
European (Non-Finnish)	0.376	0.374
Middle Eastern	0.303	0.303
South Asian	0.370	0.368
Other	0.373	0.371

dbNSFP

Source: dbNSFP

Intolerance Scores

• rvis_EVS: 0.46
• rvis_percentile_EVS: 78.59

Haploinsufficiency Scores

• pHI: 0.0488
• hipred: N
• hipred_score: 0.180
• ghis: 0.385

Essentials

• essential_gene_CRISPR: N
• essential_gene_CRISPR2: N
• essential_gene_gene_trap: N
• gene_indispensability_pred: N
• gene_indispensability_score: 0.114

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	Medium	Medium	Medium
Primary Immunodeficiency	Medium	Medium	High
Cancer	Medium	Medium	Medium

Mouse Genome Informatics

• Gene name: Tex26

Gene ontology

• Cellular component: cytoplasm