TMEM158

transmembrane protein 158

Basic information

Region (hg38): 3:45224466-45226287

Links

ENSG00000249992 ∙ NCBI:25907 ∙ OMIM:620257 ∙ HGNC:30293 ∙ Uniprot:Q8WZ71 ∙ AlphaFold ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the TMEM158 gene.

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the TMEM158 gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense			20			20
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding						0
Total	0	0	20	0	0

Variants in TMEM158

This is a list of pathogenic ClinVar variants found in the TMEM158 region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
3-45225150-A-G		not specified	Uncertain significance (Jun 16, 2024)
3-45225216-G-A		not specified	Uncertain significance (Nov 21, 2023)
3-45225217-C-T		not specified	Uncertain significance (Nov 21, 2023)
3-45225378-C-A		not specified	Uncertain significance (Dec 13, 2022)
3-45225387-C-T		not specified	Uncertain significance (Feb 11, 2022)
3-45225475-G-A		not specified	Uncertain significance (Feb 21, 2024)
3-45225486-G-A		not specified	Uncertain significance (Mar 25, 2024)
3-45225556-G-A		not specified	Uncertain significance (Mar 21, 2022)
3-45225740-G-C		not specified	Uncertain significance (Aug 13, 2021)
3-45225810-G-C		not specified	Uncertain significance (Apr 07, 2023)
3-45225856-G-A		not specified	Uncertain significance (Mar 06, 2023)
3-45225861-G-C		not specified	Uncertain significance (Mar 22, 2023)
3-45225870-G-A		not specified	Uncertain significance (Feb 10, 2022)
3-45225871-A-C		not specified	Uncertain significance (Jun 21, 2021)
3-45225891-A-G		not specified	Uncertain significance (Oct 25, 2022)
3-45225894-G-A		not specified	Uncertain significance (Jan 07, 2022)
3-45225913-C-G		not specified	Uncertain significance (Jan 26, 2022)
3-45225924-G-A		not specified	Uncertain significance (Jul 11, 2023)
3-45225951-G-C		not specified	Uncertain significance (Mar 29, 2023)
3-45225957-T-G		not specified	Uncertain significance (Aug 10, 2021)
3-45226024-G-C		not specified	Uncertain significance (Jun 30, 2023)

GnomAD

Source: gnomAD

Gene	Type	Bio Type	Transcript	Coding Exons	Length
TMEM158	protein_coding	protein_coding	ENST00000503771	1	1813

pLI Probability LOF Intolerant	pRec Probability LOF Recessive	Individuals with no LOFs	Individuals with Homozygous LOFs	Individuals with Heterozygous LOFs	Defined	p
0.149	0.646	0	0	0	0	0.00

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible in Transcript
Missense	1.09	26	47.1	0.552	0.00000226	1823
Missense in Polyphen		11	24.513	0.44874		551
Synonymous	0.962	16	21.7	0.737	0.00000109	734
Loss of Function	0.671	1	2.03	0.492	8.88e-8	43

LoF frequencies by population

Ethnicity	Sum of pLOFs	p
African & African-American	0.00	0.00
Ashkenazi Jewish	0.00	0.00
East Asian	0.00	0.00
Finnish	0.00	0.00
European (Non-Finnish)	0.00	0.00
Middle Eastern	0.00	0.00
South Asian	0.00	0.00
Other	0.00	0.00

dbNSFP

Source: dbNSFP

• Function: FUNCTION: Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide. {ECO:0000250}.

Haploinsufficiency Scores

• hipred: N
• hipred_score: 0.367
• ghis: 0.542

Essentials

• essential_gene_CRISPR: N
• essential_gene_CRISPR2: N
• gene_indispensability_pred: N
• gene_indispensability_score: 0.114

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	Medium	Low	Low
Primary Immunodeficiency	Medium	Low	Medium
Cancer	Medium	Low	Medium

Mouse Genome Informatics

• Gene name: Tmem158

Gene ontology

• Cellular component: integral component of membrane
• Molecular function: peptide binding