TMEM266

protein-coding

transmembrane protein 266

Gene summary

Enables protein homodimerization activity. Predicted to be involved in monoatomic ion transport and transmembrane transport. Located in cytosol; dendrite; and plasma membrane. [provided by Alliance of Genome Resources, Jun 2026]

Previous symbols:

C15orf27

MANE transcript

NM_152335.5

Inheritance

—

ClinVar variants

U:86B:3

Top phenotype

—

gnomAD constraint

pLI —, LoF o/e 0.63

Max pathogenic AF

—

Genomic locus

chr15:76,059,958-76,229,121

External References & Databases

Ensembl (ENSG00000169758)

Transcript & Mutation Effects

hg38 • Region Span ~169.2 kb

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GenCC Phenotypes & Disease Associations

Curated gene-disease validity assertions and inheritance patterns

No GenCC data available for this gene.

ClinVar Associated Diseases & Phenotypes

Reported disease conditions connected to TMEM266 variants in ClinVar

1 Conditions Cataloged

not specifiedTotal: 83

ClinVar Variants & Pathogenicity by Type

Statistics based on transcript NM_152335.5. Only rare variants are included.

We include only reliable ClinVar variants with their consequences to MANE Select, MANE Plus Clinical transcripts, or transcripts with TSL equal to 1. Click a count to filter the variants table below.

Slight differences between displayed counts and ClinVar may occur due to a different transcript/consequence chosen by our variant effect predictor, or because we classify Benign/Likely benign as Likely benign and Pathogenic/Likely pathogenic as Likely pathogenic.

Effect	PathogenicP	Likely pathogenicLP	VUS	Likely benignLB	BenignB	Sum
synonymous			1 clinvar	1 clinvar		2
missense			83 clinvar	2 clinvar		85
nonsense						0
start loss						0
frameshift						0
splice donor/acceptor (+/-2bp)			2 clinvar			2
Total	0	0	86	3	0	89

Loading ClinVar variants...

Transcript Catalog

Annotated transcript isoforms across RefSeq and Ensembl databases

Showing 4 of 17 transcripts

Transcript ID	Source	Protein ID	Coding Exons	MANE Status
NM_152335.5	RefSeq	NP_689548.3	10	MANE Select
ENST00000388942.9	Ensembl	ENSP00000373594.4	10	MANE Select
ENST00000484722.6	Ensembl	ENSP00000435049.2	4	Standard
ENST00000561302.6	Ensembl	ENSP00000453957.2	5	Standard

Gene Ontology (GO) Annotations & Pathways

Biological processes, molecular functions, cellular components and pathways

Cellular Component

cytosol
plasma membrane
integral component of membrane

gnomAD Constraint

Source: gnomAD

Gene type: protein_coding
Transcript type: protein_coding
Transcript: ENST00000388942
Coding exons: 10
Length: 169285
Individuals with no LoFs: 125688
Homozygous LoFs: 0
Heterozygous LoFs: 60
Defined: 125748
p: 0.000239

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible
Missense	0.751	278	316	0.881	0.0000191	3457
Missense (PolyPhen)		90	110.77	0.8125		1254
Synonymous	-0.823	158	145	1.09	0.0000106	1074
Loss of Function	1.63	14	22.3	0.628	9.53e-7	255

Population LoF Frequency

Population	CAF	p-value	Status
African	0.00032	0.00031	rare
Latino/Admixed American	0.00032	0.00032	rare
Ashkenazi Jewish	0.00010	0.000099	rare
East Asian	0.000056	0.000054	rare
Finnish	0	0.0	absent
European (Non-Finnish)	0.00029	0.00029	rare
South Asian	0.00024	0.00023	rare
Other	0.00033	0.00033	rare

dbNSFP Gene Annotations

Source: dbNSFP

Intolerance Scores

RVIS EVS: 0.2
RVIS percentile EVS: 67.36

Essentials

Essential (gene trap): N