TMSB10

protein-coding

thymosin beta 10

Gene summary

Predicted to enable actin monomer binding activity and protein sequestering activity. Predicted to be involved in regulation of cell migration. Predicted to be located in cytoskeleton. [provided by Alliance of Genome Resources, Jun 2026]

MANE transcript

NM_021103.4

Inheritance

—

ClinVar variants

U:2

Top phenotype

—

gnomAD constraint

pLI —, LoF o/e 1.38

Max pathogenic AF

—

Genomic locus

chr2:84,905,656-84,906,671

External References & Databases

Ensembl (ENSG00000034510)

Transcript & Mutation Effects

hg38 • Region Span ~1.0 kb

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GenCC Phenotypes & Disease Associations

Curated gene-disease validity assertions and inheritance patterns

No GenCC data available for this gene.

ClinVar Associated Diseases & Phenotypes

Reported disease conditions connected to TMSB10 variants in ClinVar

1 Conditions Cataloged

not specifiedTotal: 2

ClinVar Variants & Pathogenicity by Type

Statistics based on transcript NM_021103.4. Only rare variants are included.

We include only reliable ClinVar variants with their consequences to MANE Select, MANE Plus Clinical transcripts, or transcripts with TSL equal to 1. Click a count to filter the variants table below.

Slight differences between displayed counts and ClinVar may occur due to a different transcript/consequence chosen by our variant effect predictor, or because we classify Benign/Likely benign as Likely benign and Pathogenic/Likely pathogenic as Likely pathogenic.

Effect	PathogenicP	Likely pathogenicLP	VUS	Likely benignLB	BenignB	Sum
synonymous						0
missense			2 clinvar			2
nonsense						0
start loss						0
frameshift						0
splice donor/acceptor (+/-2bp)						0
Total	0	0	2	0	0	2

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Transcript Catalog

Annotated transcript isoforms across RefSeq and Ensembl databases

Showing 4 of 27 transcripts

Transcript ID	Source	Protein ID	Coding Exons	MANE Status
NM_021103.4	RefSeq	NP_066926.1	2	MANE Select
ENST00000233143.6	Ensembl	ENSP00000233143.4	2	MANE Select
ENST00000877287.1	Ensembl	ENSP00000547346.1	2	Standard
ENST00000877288.1	Ensembl	ENSP00000547347.1	2	Standard

Gene Ontology (GO) Annotations & Pathways

Biological processes, molecular functions, cellular components and pathways

Biological Process

actin filament organization
regulation of cell migration
sequestering of actin monomers

Molecular Function

actin monomer binding
protein binding

Cellular Component

cytoplasm
cytoskeleton

gnomAD Constraint

Source: gnomAD

Gene type: protein_coding
Transcript type: protein_coding
Transcript: ENST00000233143
Coding exons: 2
Length: 1047
Individuals with no LoFs: 125688
Homozygous LoFs: 0
Heterozygous LoFs: 2
Defined: 125690
p: 0.00000796

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible
Missense	0.906	11	23.3	0.472	0.00000101	290
Missense (PolyPhen)		0	3.6288	0		60
Synonymous	0.124	9	9.48	0.949	4.25e-7	73
Loss of Function	-0.421	2	1.45	1.38	6.01e-8	22

Population LoF Frequency

Population	CAF	p-value	Status
African	0	0.0	absent
Latino/Admixed American	0	0.0	absent
Ashkenazi Jewish	0.000099	0.000099	rare
East Asian	0	0.0	absent
Finnish	0.000046	0.000046	rare
European (Non-Finnish)	0	0.0	absent
South Asian	0	0.0	absent
Other	0	0.0	absent

dbNSFP Gene Annotations

Source: dbNSFP

Function: FUNCTION: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). {ECO:0000250}.;

Recessive Scores

pRec: 0.218

Intolerance Scores

LoFtool: 0.596
RVIS EVS: 0.15
RVIS percentile EVS: 63.81

Essentials

Essential (CRISPR): N
Essential (CRISPR2): N
Essential (gene trap): N
Indispensability pred.: E
Indispensability score: 0.501