TNFRSF10A-DT

TNFRSF10A divergent transcript, the group of Divergent transcripts

Basic information

Region (hg38): 8:23224471-23230926

Links

ENSG00000246582 ∙ NCBI:389641 ∙ ∙ HGNC:52647 ∙ ∙ ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the TNFRSF10A-DT gene.

• Inborn genetic diseases (7 variants)
• not provided (3 variants)

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the TNFRSF10A-DT gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense						0
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding			7		2	9
Total	0	0	7	0	2

Variants in TNFRSF10A-DT

This is a list of pathogenic ClinVar variants found in the TNFRSF10A-DT region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
8-23224751-C-G			Benign (Dec 31, 2019)
8-23224757-T-G		not specified	Uncertain significance (Jul 14, 2021)
8-23224767-C-A		not specified	Uncertain significance (Jan 17, 2024)
8-23224781-A-G		not specified	Uncertain significance (Feb 27, 2024)
8-23224826-G-A		not specified	Uncertain significance (Mar 04, 2024)
8-23224856-C-G			Benign (May 29, 2018)
8-23224874-C-T		not specified	Uncertain significance (Oct 02, 2023)
8-23224920-G-C		not specified	Uncertain significance (Dec 16, 2023)
8-23224952-A-C		not specified	Uncertain significance (Jul 27, 2021)
8-23224953-C-T		not specified	Uncertain significance (Sep 15, 2021)
8-23224967-G-T		not specified	Uncertain significance (May 20, 2024)
8-23224970-G-T		not specified	Uncertain significance (Feb 15, 2023)
8-23224977-C-T		not specified	Uncertain significance (Jan 23, 2024)
8-23225005-A-T		not specified	Uncertain significance (Mar 27, 2023)
8-23225041-T-A		not specified	Uncertain significance (Nov 12, 2021)
8-23225458-G-T			not provided (-)

GnomAD

Source: gnomAD

dbNSFP

Source: dbNSFP