TRIM15

tripartite motif containing 15, the group of Tripartite motif family|Ring finger proteins

Basic information

Region (hg38): 6:30163206-30172693

Previous symbols: [ "ZNF178" ]

Links

ENSG00000204610 ∙ NCBI:89870 ∙ ∙ HGNC:16284 ∙ Uniprot:Q9C019 ∙ AlphaFold ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the TRIM15 gene.

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the TRIM15 gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense			22	1		23
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding						0
Total	0	0	22	1	0

Variants in TRIM15

This is a list of pathogenic ClinVar variants found in the TRIM15 region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
6-30163691-G-A		not specified	Uncertain significance (Nov 06, 2023)
6-30163717-T-G		not specified	Uncertain significance (Nov 10, 2022)
6-30163781-C-T		not specified	Uncertain significance (Jun 12, 2023)
6-30163794-G-C		not specified	Uncertain significance (Apr 28, 2022)
6-30163845-T-C		not specified	Uncertain significance (May 02, 2024)
6-30163870-G-C		not specified	Uncertain significance (May 14, 2024)
6-30163904-C-G		not specified	Uncertain significance (Sep 01, 2021)
6-30163904-C-T		not specified	Uncertain significance (May 20, 2024)
6-30163913-C-T		not specified	Uncertain significance (Jun 17, 2022)
6-30163946-G-A		not specified	Uncertain significance (Dec 20, 2023)
6-30163951-G-T		not specified	Uncertain significance (Feb 15, 2023)
6-30164010-C-T		not specified	Uncertain significance (Sep 01, 2021)
6-30164063-C-T		not specified	Uncertain significance (May 06, 2024)
6-30167188-A-G		not specified	Uncertain significance (Oct 26, 2021)
6-30167225-T-C		not specified	Uncertain significance (Feb 17, 2022)
6-30168307-T-C		not specified	Uncertain significance (Jan 30, 2024)
6-30168318-A-G		not specified	Uncertain significance (Sep 16, 2021)
6-30168369-C-A		not specified	Uncertain significance (Jan 30, 2024)
6-30168441-A-T		not specified	Likely benign (Nov 29, 2021)
6-30168471-G-A		not specified	Uncertain significance (Apr 12, 2022)
6-30170602-T-C		not specified	Uncertain significance (Feb 15, 2023)
6-30171840-A-T		not specified	Uncertain significance (May 22, 2023)
6-30171853-A-G		not specified	Uncertain significance (May 17, 2023)
6-30171901-G-A		not specified	Uncertain significance (May 13, 2024)
6-30171928-C-T		not specified	Uncertain significance (Sep 25, 2023)

GnomAD

Source: gnomAD

Gene	Type	Bio Type	Transcript	Coding Exons	Length
TRIM15	protein_coding	protein_coding	ENST00000376694	7	9481

pLI Probability LOF Intolerant	pRec Probability LOF Recessive	Individuals with no LOFs	Individuals with Homozygous LOFs	Individuals with Heterozygous LOFs	Defined	p
7.76e-9	0.278	125455	1	292	125748	0.00117

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible in Transcript
Missense	0.412	245	264	0.929	0.0000138	2992
Missense in Polyphen		51	64.715	0.78807		782
Synonymous	1.26	102	120	0.853	0.00000737	927
Loss of Function	0.626	14	16.8	0.835	8.66e-7	185

LoF frequencies by population

Ethnicity	Sum of pLOFs	p
African & African-American	0.00380	0.00379
Ashkenazi Jewish	0.00564	0.00557
East Asian	0.000164	0.000163
Finnish	0.00	0.00
European (Non-Finnish)	0.000858	0.000818
Middle Eastern	0.000164	0.000163
South Asian	0.000268	0.000229
Other	0.00148	0.00147

dbNSFP

Source: dbNSFP

Intolerance Scores

• loftool: 0.856
• rvis_EVS: 1.91
• rvis_percentile_EVS: 97.36

Haploinsufficiency Scores

• pHI: 0.0920
• hipred: N
• hipred_score: 0.220
• ghis: 0.398

Essentials

• essential_gene_CRISPR: N
• essential_gene_CRISPR2: N
• essential_gene_gene_trap: N
• gene_indispensability_pred: E
• gene_indispensability_score: 0.883

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	Medium	Medium	Medium
Primary Immunodeficiency	Medium	Medium	Medium
Cancer	Medium	Medium	Medium

Mouse Genome Informatics

• Gene name: Trim15

Gene ontology

• Biological process: mesodermal cell fate determination;positive regulation of type I interferon production;innate immune response;positive regulation of DNA-binding transcription factor activity;positive regulation of NF-kappaB transcription factor activity;positive regulation of RIG-I signaling pathway;negative regulation of intracellular transport of viral material;negative regulation of viral release from host cell
• Molecular function: protein binding;zinc ion binding