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GeneBe

TRIM34

tripartite motif containing 34, the group of Tripartite motif family|Ring finger proteins

Basic information

Region (hg38): 11:5619763-5644398

Previous symbols: [ "RNF21" ]

Links

ENSG00000258659NCBI:53840OMIM:605684HGNC:10063Uniprot:Q9BYJ4AlphaFoldGenCCjaxSfariGnomADPubmed

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the TRIM34 gene.

  • Malignant tumor of prostate (1 variants)

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the TRIM34 gene is commonly pathogenic or not.

Variant type Pathogenic Likely pathogenic VUS Likely benign Benign Sum
synonymous 0
missense 0
nonsense 0
start loss 0
frameshift 0
inframe indel 0
splice variant 0
non coding 1 1
Total 0 0 1 0 0

Variants in TRIM34

This is a list of pathogenic ClinVar variants found in the TRIM34 region.

Position Type Phenotype Significance ClinVar
11-5632327-G-A Malignant tumor of prostate Uncertain significance (-)link

GnomAD

Source: gnomAD

GeneTypeBio TypeTranscript Coding Exons Length
TRIM34protein_codingprotein_codingENST00000514226 724635
pLI Probability
LOF Intolerant
pRec Probability
LOF Recessive
Individuals with
no LOFs
Individuals with
Homozygous LOFs
Individuals with
Heterozygous LOFs
Defined p
0.000001330.8391257120341257460.000135
Z-Score Observed Expected Observed/Expected Mutation Rate Total Possible in Transcript
Missense-0.1452612551.030.00001263218
Missense in Polyphen6068.2850.87867960
Synonymous0.9878092.00.8690.00000441897
Loss of Function1.451218.80.6408.79e-7239

LoF frequencies by population

EthnicitySum of pLOFs p
African & African-American0.00002890.0000289
Ashkenazi Jewish0.000.00
East Asian0.0003280.000326
Finnish0.000.00
European (Non-Finnish)0.0001980.000193
Middle Eastern0.0003280.000326
South Asian0.0001660.000163
Other0.000.00

dbNSFP

Source: dbNSFP

Function
FUNCTION: May function as antiviral protein and may contribute to the defense against retroviral infections. {ECO:0000269|PubMed:17156811}.;
Pathway
Cytokine Signaling in Immune system;Immune System;Interferon gamma signaling;Interferon Signaling (Consensus)

Recessive Scores

pRec
0.0811

Intolerance Scores

loftool
0.712
rvis_EVS
0.84
rvis_percentile_EVS
88.36

Haploinsufficiency Scores

pHI
hipred
N
hipred_score
0.112
ghis
0.420

Essentials

essential_gene_CRISPR
N
essential_gene_CRISPR2
N
essential_gene_gene_trap
gene_indispensability_pred
E
gene_indispensability_score
0.966

Mouse Genome Informatics

Gene name
Trim34b
Phenotype

Gene ontology

Biological process
positive regulation of DNA-binding transcription factor activity;defense response to virus;interferon-gamma-mediated signaling pathway;protein trimerization
Cellular component
cytoplasm;cytosol
Molecular function
molecular_function;zinc ion binding