TRIM34

tripartite motif containing 34, the group of Tripartite motif family|Ring finger proteins

Basic information

Region (hg38): 11:5619763-5644398

Previous symbols: [ "RNF21" ]

Links

ENSG00000258659 ∙ NCBI:53840 ∙ OMIM:605684 ∙ HGNC:10063 ∙ Uniprot:Q9BYJ4 ∙ AlphaFold ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the TRIM34 gene.

• Malignant tumor of prostate (1 variants)

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the TRIM34 gene is commonly pathogenic or not.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense						0
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice variant						0
non coding			1			1
Total	0	0	1	0	0

Variants in TRIM34

This is a list of pathogenic ClinVar variants found in the TRIM34 region.

Position	Type	Phenotype	Significance	ClinVar
11-5632327-G-A		Malignant tumor of prostate	Uncertain significance (-)

GnomAD

Source: gnomAD

Gene	Type	Bio Type	Transcript	Coding Exons	Length
TRIM34	protein_coding	protein_coding	ENST00000514226	7	24635

pLI Probability LOF Intolerant	pRec Probability LOF Recessive	Individuals with no LOFs	Individuals with Homozygous LOFs	Individuals with Heterozygous LOFs	Defined	p
0.00000133	0.839	125712	0	34	125746	0.000135

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible in Transcript
Missense	-0.145	261	255	1.03	0.0000126	3218
Missense in Polyphen		60	68.285	0.87867		960
Synonymous	0.987	80	92.0	0.869	0.00000441	897
Loss of Function	1.45	12	18.8	0.640	8.79e-7	239

LoF frequencies by population

Ethnicity	Sum of pLOFs	p
African & African-American	0.0000289	0.0000289
Ashkenazi Jewish	0.00	0.00
East Asian	0.000328	0.000326
Finnish	0.00	0.00
European (Non-Finnish)	0.000198	0.000193
Middle Eastern	0.000328	0.000326
South Asian	0.000166	0.000163
Other	0.00	0.00

dbNSFP

Source: dbNSFP

• Function: FUNCTION: May function as antiviral protein and may contribute to the defense against retroviral infections. {ECO:0000269|PubMed:17156811}.
• Pathway: Cytokine Signaling in Immune system;Immune System;Interferon gamma signaling;Interferon Signaling (Consensus)

Recessive Scores

• pRec: 0.0811

Intolerance Scores

• loftool: 0.712
• rvis_EVS: 0.84
• rvis_percentile_EVS: 88.36

Haploinsufficiency Scores

• hipred: N
• hipred_score: 0.112
• ghis: 0.420

Essentials

• essential_gene_CRISPR: N
• essential_gene_CRISPR2: N
• gene_indispensability_pred: E
• gene_indispensability_score: 0.966

Mouse Genome Informatics

• Gene name: Trim34b

Gene ontology

• Biological process: positive regulation of DNA-binding transcription factor activity;defense response to virus;interferon-gamma-mediated signaling pathway;protein trimerization
• Cellular component: cytoplasm;cytosol
• Molecular function: molecular_function;zinc ion binding