TRIM34

tripartite motif containing 34, the group of Tripartite motif family|Ring finger proteins

Basic information

Region (hg38): 11:5619764-5644398

Previous symbols: [ "RNF21" ]

Links

ENSG00000258659NCBI:53840OMIM:605684HGNC:10063Uniprot:Q9BYJ4AlphaFoldGenCCjaxSfariGnomADPubmedClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the TRIM34 gene.

  • Malignant tumor of prostate (1 variants)

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the TRIM34 gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type Pathogenic Likely pathogenic VUS Likely benign Benign Sum
synonymous
0
missense
0
nonsense
0
start loss
0
frameshift
0
inframe indel
0
splice donor/acceptor (+/-2bp)
0
splice region
0
non coding
1
clinvar
1
Total 0 0 1 0 0

Variants in TRIM34

This is a list of pathogenic ClinVar variants found in the TRIM34 region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position Type Phenotype Significance ClinVar
11-5632327-G-A Malignant tumor of prostate Uncertain significance (-)161478

GnomAD

Source: gnomAD

GeneTypeBio TypeTranscript Coding Exons Length
TRIM34protein_codingprotein_codingENST00000514226 724635
pLI Probability
LOF Intolerant
pRec Probability
LOF Recessive
Individuals with
no LOFs
Individuals with
Homozygous LOFs
Individuals with
Heterozygous LOFs
Defined p
0.000001330.8391257120341257460.000135
Z-Score Observed Expected Observed/Expected Mutation Rate Total Possible in Transcript
Missense-0.1452612551.030.00001263218
Missense in Polyphen6068.2850.87867960
Synonymous0.9878092.00.8690.00000441897
Loss of Function1.451218.80.6408.79e-7239

LoF frequencies by population

EthnicitySum of pLOFs p
African & African-American0.00002890.0000289
Ashkenazi Jewish0.000.00
East Asian0.0003280.000326
Finnish0.000.00
European (Non-Finnish)0.0001980.000193
Middle Eastern0.0003280.000326
South Asian0.0001660.000163
Other0.000.00

dbNSFP

Source: dbNSFP

Function
FUNCTION: May function as antiviral protein and may contribute to the defense against retroviral infections. {ECO:0000269|PubMed:17156811}.;
Pathway
Cytokine Signaling in Immune system;Immune System;Interferon gamma signaling;Interferon Signaling (Consensus)

Recessive Scores

pRec
0.0811

Intolerance Scores

loftool
0.712
rvis_EVS
0.84
rvis_percentile_EVS
88.36

Haploinsufficiency Scores

pHI
hipred
N
hipred_score
0.112
ghis
0.420

Essentials

essential_gene_CRISPR
N
essential_gene_CRISPR2
N
essential_gene_gene_trap
gene_indispensability_pred
E
gene_indispensability_score
0.966

Mouse Genome Informatics

Gene name
Trim34b
Phenotype

Gene ontology

Biological process
positive regulation of DNA-binding transcription factor activity;defense response to virus;interferon-gamma-mediated signaling pathway;protein trimerization
Cellular component
cytoplasm;cytosol
Molecular function
molecular_function;zinc ion binding