TRIM61

tripartite motif containing 61, the group of Tripartite motif family|Ring finger proteins

Basic information

Region (hg38): 4:164954445-164977668

Previous symbols: [ "RNF35" ]

Links

ENSG00000183439 ∙ NCBI:391712 ∙ OMIM:619417 ∙ HGNC:24339 ∙ Uniprot:Q5EBN2 ∙ AlphaFold ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the TRIM61 gene.

• Inborn genetic diseases (15 variants)

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the TRIM61 gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense			15			15
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding						0
Total	0	0	15	0	0

Variants in TRIM61

This is a list of pathogenic ClinVar variants found in the TRIM61 region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
4-164969486-T-C		not specified	Uncertain significance (Feb 03, 2023)
4-164969513-T-C		not specified	Uncertain significance (May 18, 2022)
4-164969521-A-T		not specified	Uncertain significance (Aug 02, 2022)
4-164969554-G-A		not specified	Uncertain significance (Aug 23, 2021)
4-164969597-C-G		not specified	Uncertain significance (Jun 03, 2022)
4-164969663-G-A		not specified	Uncertain significance (Apr 24, 2023)
4-164969678-G-C		not specified	Uncertain significance (Oct 04, 2022)
4-164969690-T-G		not specified	Uncertain significance (Sep 01, 2021)
4-164969714-A-C		not specified	Uncertain significance (Jul 12, 2023)
4-164969740-C-T		not specified	Uncertain significance (Mar 01, 2023)
4-164969758-T-C		not specified	Uncertain significance (Sep 19, 2023)
4-164969779-G-A		not specified	Uncertain significance (Aug 28, 2023)
4-164969795-G-T		not specified	Uncertain significance (Jan 02, 2024)
4-164969802-G-C		not specified	Uncertain significance (Aug 21, 2023)
4-164969887-C-T		not specified	Uncertain significance (Jun 29, 2023)
4-164969933-T-C		not specified	Uncertain significance (Aug 17, 2022)
4-164969989-G-A		not specified	Uncertain significance (Aug 17, 2022)

GnomAD

Source: gnomAD

Gene	Type	Bio Type	Transcript	Coding Exons	Length
TRIM61	protein_coding	protein_coding	ENST00000329314	2	23223

pLI Probability LOF Intolerant	pRec Probability LOF Recessive	Individuals with no LOFs	Individuals with Homozygous LOFs	Individuals with Heterozygous LOFs	Defined	p
0.000106	0.377	0	0	0	0	0.00

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible in Transcript
Missense	1.04	58	85.1	0.682	0.00000398	1353
Missense in Polyphen		13	20.332	0.63939		321
Synonymous	1.63	21	32.9	0.638	0.00000174	369
Loss of Function	0.0501	6	6.13	0.978	3.43e-7	97

LoF frequencies by population

Ethnicity	Sum of pLOFs	p
African & African-American	0.00	0.00
Ashkenazi Jewish	0.00	0.00
East Asian	0.00	0.00
Finnish	0.00	0.00
European (Non-Finnish)	0.00	0.00
Middle Eastern	0.00	0.00
South Asian	0.00	0.00
Other	0.00	0.00

dbNSFP

Source: dbNSFP

Recessive Scores

• pRec: 0.0927

Haploinsufficiency Scores

• pHI: 0.137
• hipred: N
• hipred_score: 0.218
• ghis: 0.607

Essentials

• essential_gene_CRISPR: N
• essential_gene_gene_trap: N
• gene_indispensability_pred: E
• gene_indispensability_score: 0.570

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	Medium	Medium	Medium
Primary Immunodeficiency	Medium	Medium	Medium
Cancer	Medium	Medium	Medium

Mouse Genome Informatics

• Gene name: Trim61

Gene ontology

• Molecular function: zinc ion binding