TRIM77

tripartite motif containing 77, the group of Tripartite motif family|Ring finger proteins

Basic information

Region (hg38): 11:89710298-89717872

Previous symbols: [ "TRIM77P" ]

Links

ENSG00000214414 ∙ NCBI:390231 ∙ ∙ HGNC:34228 ∙ Uniprot:I1YAP6 ∙ AlphaFold ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the TRIM77 gene.

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the TRIM77 gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense			31	1		32
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding						0
Total	0	0	31	1	0

Variants in TRIM77

This is a list of pathogenic ClinVar variants found in the TRIM77 region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
11-89710305-T-G		not specified	Uncertain significance (Oct 13, 2023)
11-89710311-A-G		not specified	Uncertain significance (Nov 14, 2023)
11-89710315-C-T		not specified	Uncertain significance (Feb 23, 2023)
11-89710374-G-C		not specified	Uncertain significance (Jul 25, 2023)
11-89710431-G-T		not specified	Uncertain significance (Mar 16, 2024)
11-89710545-T-G		not specified	Uncertain significance (Feb 27, 2023)
11-89710644-T-G		not specified	Uncertain significance (Jun 13, 2024)
11-89710647-C-A		not specified	Uncertain significance (Jun 17, 2024)
11-89710670-C-A		not specified	Uncertain significance (Jul 19, 2022)
11-89711438-T-C		not specified	Uncertain significance (Dec 28, 2023)
11-89711443-A-G		not specified	Uncertain significance (Sep 29, 2022)
11-89711452-C-A		not specified	Uncertain significance (Apr 22, 2024)
11-89711477-G-A		not specified	Uncertain significance (Aug 17, 2021)
11-89714208-G-A		not specified	Uncertain significance (Nov 17, 2022)
11-89714229-A-T		not specified	Uncertain significance (Oct 06, 2022)
11-89714240-G-A		not specified	Uncertain significance (Jun 14, 2023)
11-89714247-A-C		not specified	Uncertain significance (Jul 20, 2022)
11-89714256-G-A		not specified	Uncertain significance (Apr 05, 2023)
11-89714276-G-A		not specified	Uncertain significance (Jun 07, 2023)
11-89714298-G-A		not specified	Uncertain significance (Oct 26, 2022)
11-89714303-A-G		not specified	Uncertain significance (Jan 23, 2024)
11-89715167-G-A		not specified	Uncertain significance (Dec 27, 2022)
11-89715170-G-A		not specified	Likely benign (May 24, 2023)
11-89715921-C-T		not specified	Uncertain significance (Sep 12, 2023)
11-89715960-G-T		not specified	Uncertain significance (Dec 28, 2022)

GnomAD

Source: gnomAD

Gene	Type	Bio Type	Transcript	Coding Exons	Length
TRIM77	protein_coding	protein_coding	ENST00000398290	6	7574

pLI Probability LOF Intolerant	pRec Probability LOF Recessive	Individuals with no LOFs	Individuals with Homozygous LOFs	Individuals with Heterozygous LOFs	Defined	p
0.0000102	0.579	0	0	0	0	0.00

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible in Transcript
Missense	1.22	172	223	0.771	0.0000108	2999
Missense in Polyphen		41	52.355	0.78311		781
Synonymous	1.10	65	77.3	0.841	0.00000375	808
Loss of Function	0.795	9	12.0	0.752	5.04e-7	181

LoF frequencies by population

Ethnicity	Sum of pLOFs	p
African & African-American	0.00	0.00
Ashkenazi Jewish	0.00	0.00
East Asian	0.00	0.00
Finnish	0.00	0.00
European (Non-Finnish)	0.00	0.00
Middle Eastern	0.00	0.00
South Asian	0.00	0.00
Other	0.00	0.00

dbNSFP

Source: dbNSFP

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	Medium	Medium	Medium
Primary Immunodeficiency	Medium	Medium	Medium
Cancer	Medium	Medium	Medium

Gene ontology

• Molecular function: zinc ion binding