TSIX

TSIX transcript, XIST antisense RNA, the group of Long non-coding RNAs with non-systematic symbols

Basic information

Region (hg38): X:73792205-73829231

Links

ENSG00000270641

∙ NCBI:9383 ∙ OMIM:300181 ∙ HGNC:12377 ∙ ∙ ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the TSIX gene.

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the TSIX gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense						0
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding						0
Total	0	0	0	0	0

Variants in TSIX

This is a list of pathogenic ClinVar variants found in the TSIX region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Phenotype	Significance	ClinVar
X-73820953-A-G	XIST-related disorder	Benign (Feb 24, 2019)	3042649
X-73821427-T-G	TSIX-related disorder	Likely benign (Aug 30, 2023)	3041021
X-73821764-T-A	XIST-related disorder	Likely benign (Mar 16, 2021)	3038264
X-73821979-C-T	TSIX-related disorder	Likely benign (Feb 24, 2022)	3036287
X-73822111-G-A	XIST-related disorder	Likely benign (Dec 13, 2019)	3048676
X-73822187-A-C	TSIX-related disorder	Likely benign (Mar 23, 2022)	3048329
X-73823081-T-G	XIST-related disorder	Benign (Nov 06, 2019)	3045578
X-73823462-G-A	TSIX-related disorder	Benign (Feb 24, 2019)	3041924
X-73823811-A-T	XIST-related disorder	Benign (Nov 25, 2019)	3045837
X-73823824-TG-T	XIST-related disorder	Benign (Jan 20, 2020)	3038685
X-73823963-T-C	TSIX-related disorder	Benign (Aug 09, 2019)	3049478
X-73824521-G-C	XIST-related disorder	Likely benign (Sep 09, 2024)	3350445
X-73827076-ATC-A	TSIX-related disorder	Likely benign (Jun 26, 2019)	3042415
X-73827109-G-A	TSIX-related disorder	Likely benign (May 16, 2022)	3042582
X-73827241-G-A	TSIX-related disorder	Likely benign (Nov 02, 2022)	3036330
X-73827734-C-T	XIST-related disorder	Benign (Jan 20, 2020)	3039573

GnomAD

Source: gnomAD

dbNSFP

Source: dbNSFP

Mouse Genome Informatics

Gene name: Tsix
Phenotype: embryo phenotype; reproductive system phenotype; normal phenotype; mortality/aging (the observable characteristics related to the ability of a mammalian organism to live and age that are manifested throughout development and life span); cardiovascular system phenotype (the observable morphological and physiological characteristics of the mammalian heart, blood vessels, or circulatory system that are manifested through development and lifespan); digestive/alimentary phenotype; cellular phenotype; growth/size/body region phenotype;