WEE2-AS1

WEE2 antisense RNA 1, the group of Antisense RNAs

Basic information

Region (hg38): 7:141704003-141738346

Links

ENSG00000228775 ∙ NCBI:285962 ∙ ∙ HGNC:48669 ∙ ∙ ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the WEE2-AS1 gene.

• Inborn genetic diseases (29 variants)
• not provided (8 variants)
• Oocyte maturation defect 5 (6 variants)

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the WEE2-AS1 gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense						0
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)	1				1	2
splice region						0
non coding	6		28	4	2	40
Total	7	0	28	4	3

Highest pathogenic variant AF is 0.0000394

Variants in WEE2-AS1

This is a list of pathogenic ClinVar variants found in the WEE2-AS1 region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
7-141708810-T-C		not specified	Uncertain significance (May 31, 2023)
7-141708820-A-T		not specified	Uncertain significance (Dec 05, 2022)
7-141708827-G-C		not specified	Uncertain significance (Jul 26, 2022)
7-141708868-C-T		not specified	Likely benign (Apr 04, 2024)
7-141708918-A-T		not specified	Uncertain significance (Dec 05, 2023)
7-141708921-C-T		not specified	Uncertain significance (Aug 02, 2022)
7-141708944-C-T		WEE2-related disorder	Likely benign (Apr 26, 2019)
7-141708967-C-T		not specified	Uncertain significance (Oct 27, 2021)
7-141708968-G-A			Likely benign (Jul 31, 2018)
7-141708977-CAAAG-C		Oocyte maturation defect 5 • WEE2-related disorder	Pathogenic (Apr 12, 2024)
7-141709035-G-C		not specified	Uncertain significance (Oct 05, 2023)
7-141709045-C-T		not specified	Uncertain significance (Jun 22, 2021)
7-141709058-C-T		WEE2-related disorder	Likely benign (Apr 05, 2019)
7-141714268-G-A		WEE2-related disorder	Likely benign (Jul 02, 2019)
7-141714353-T-C		Oocyte maturation defect 5	Uncertain significance (Mar 26, 2024)
7-141714379-T-C			Benign (Jul 16, 2018)
7-141716226-G-C		not specified	Uncertain significance (Dec 13, 2021)
7-141716263-C-A		not specified	Uncertain significance (Jan 30, 2024)
7-141719084-C-T		Oocyte maturation defect 5	Pathogenic (Apr 10, 2023)
7-141719085-G-A		not specified	Uncertain significance (Jan 07, 2022)
7-141719181-G-A		not specified	Uncertain significance (Oct 27, 2023)
7-141719186-G-C		Oocyte maturation defect 5	Pathogenic (Apr 10, 2023)
7-141719205-T-C		not specified	Uncertain significance (Aug 10, 2021)
7-141719210-C-T		not specified	Uncertain significance (Feb 27, 2023)
7-141719211-G-A		not specified	Uncertain significance (Nov 10, 2021)

GnomAD

Source: gnomAD

dbNSFP

Source: dbNSFP