WT1-AS

WT1 antisense RNA, the group of Antisense RNAs

Basic information

Region (hg38): 11:32435324-32500645

Previous symbols: [ "WIT1" ]

Links

ENSG00000183242 ∙ NCBI:51352 ∙ OMIM:607899 ∙ HGNC:18135 ∙ Uniprot:Q06250 ∙ AlphaFold ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the WT1-AS gene.

• not provided (5 variants)
• Drash syndrome;Frasier syndrome;Wilms tumor 1;11p partial monosomy syndrome (1 variants)

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the WT1-AS gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense						0
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding				3	3	6
Total	0	0	0	3	3

Variants in WT1-AS

This is a list of pathogenic ClinVar variants found in the WT1-AS region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
11-32435325-C-A		11p partial monosomy syndrome;Drash syndrome;Frasier syndrome;Wilms tumor 1	Likely benign (Sep 28, 2022)
11-32435325-C-G		Drash syndrome;Frasier syndrome;Wilms tumor 1;11p partial monosomy syndrome	Likely benign (May 30, 2023)
11-32435325-C-T		Drash syndrome;Frasier syndrome;Wilms tumor 1;11p partial monosomy syndrome	Likely benign (Apr 12, 2022)
11-32435326-G-A		Drash syndrome;Frasier syndrome;Wilms tumor 1;11p partial monosomy syndrome	Uncertain significance (Jul 15, 2023)
11-32435326-G-T		Drash syndrome;Frasier syndrome;Wilms tumor 1;11p partial monosomy syndrome	Uncertain significance (Oct 02, 2022)
11-32435327-T-C		Drash syndrome;Wilms tumor 1;11p partial monosomy syndrome;Frasier syndrome	Uncertain significance (Sep 02, 2022)
11-32435327-T-G		Wilms tumor 1;11p partial monosomy syndrome;Frasier syndrome;Drash syndrome	Uncertain significance (Dec 11, 2023)
11-32435327-TG-GT		Frasier syndrome;Drash syndrome;Wilms tumor 1;11p partial monosomy syndrome	Uncertain significance (Aug 13, 2021)
11-32435328-G-A		Frasier syndrome;11p partial monosomy syndrome;Drash syndrome;Wilms tumor 1	Likely benign (Nov 18, 2021)
11-32435328-G-T		Wilms tumor 1;11p partial monosomy syndrome;Drash syndrome;Frasier syndrome	Likely benign (Jun 22, 2022)
11-32435329-G-A		Wilms tumor 1;11p partial monosomy syndrome;Drash syndrome;Frasier syndrome • Drash syndrome	Uncertain significance (May 07, 2023)
11-32435329-G-C		Wilms tumor 1;11p partial monosomy syndrome;Drash syndrome;Frasier syndrome • Drash syndrome	Uncertain significance (Feb 18, 2024)
11-32435332-G-A		Drash syndrome;Frasier syndrome;Wilms tumor 1;11p partial monosomy syndrome	Uncertain significance (Nov 17, 2023)
11-32435332-G-T		Wilms tumor 1 • Hereditary cancer-predisposing syndrome	Uncertain significance (Apr 28, 2021)
11-32435332-GC-TA		Wilms tumor 1;11p partial monosomy syndrome;Frasier syndrome;Drash syndrome • Hereditary cancer-predisposing syndrome • 8 conditions • Drash syndrome	Uncertain significance (Mar 05, 2024)
11-32435332-GC-AT		Drash syndrome;Frasier syndrome;Wilms tumor 1;11p partial monosomy syndrome	Uncertain significance (Oct 28, 2023)
11-32435333-C-A		Drash syndrome • Hereditary cancer-predisposing syndrome • Frasier syndrome;Drash syndrome;Wilms tumor 1;11p partial monosomy syndrome • WT1-related disorder	Uncertain significance (Dec 25, 2023)
11-32435333-C-T		Drash syndrome;Frasier syndrome;Wilms tumor 1;11p partial monosomy syndrome • Wilms tumor 1	Uncertain significance (Nov 07, 2023)
11-32435334-C-T		Drash syndrome;Frasier syndrome;Wilms tumor 1;11p partial monosomy syndrome • Hereditary cancer-predisposing syndrome • 8 conditions • WT1-related disorder	Likely benign (Oct 19, 2023)
11-32435335-G-A		Wilms tumor 1;11p partial monosomy syndrome;Drash syndrome;Frasier syndrome • 8 conditions • WT1-related disorder	Uncertain significance (Nov 08, 2023)
11-32435335-G-C		Drash syndrome;Wilms tumor 1;11p partial monosomy syndrome;Frasier syndrome	Uncertain significance (Mar 24, 2023)
11-32435336-G-C		Wilms tumor 1	Uncertain significance (Aug 15, 2023)
11-32435336-G-T		Frasier syndrome;Wilms tumor 1;11p partial monosomy syndrome;Drash syndrome	Uncertain significance (Oct 06, 2021)
11-32435337-G-A		Wilms tumor 1;11p partial monosomy syndrome;Frasier syndrome;Drash syndrome • Wilms tumor 1 • WT1-related disorder	Likely benign (Feb 24, 2023)
11-32435337-G-C		Drash syndrome;Frasier syndrome;Wilms tumor 1;11p partial monosomy syndrome	Uncertain significance (May 26, 2020)

GnomAD

Source: gnomAD

dbNSFP

Source: dbNSFP

Haploinsufficiency Scores

• pHI: 0.267

Mouse Genome Informatics

• Gene name: Wt1os

Gene ontology

• Biological process: biological_process
• Cellular component: cellular_component
• Molecular function: molecular_function;protein binding