ZDHHC11

protein-coding

zinc finger DHHC-type containing 11, the group of Zinc fingers DHHC-type

Gene summary

Enables signaling adaptor activity. Involved in antiviral innate immune response and positive regulation of defense response to virus by host. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

MANE transcript

NM_024786.3

Inheritance

—

ClinVar variants

U:106B:18

Top phenotype

—

gnomAD constraint

pLI —, LoF o/e 1.08

Max pathogenic AF

—

Genomic locus

chr5:795,605-858,973

External References & Databases

Ensembl (ENSG00000188818)

Transcript & Mutation Effects

hg38 • Region Span ~63.4 kb

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GenCC Phenotypes & Disease Associations

Curated gene-disease validity assertions and inheritance patterns

No GenCC data available for this gene.

ClinVar Associated Diseases & Phenotypes

Reported disease conditions connected to ZDHHC11 variants in ClinVar

2 Conditions Cataloged

not specifiedTotal: 115

not providedTotal: 6

ClinVar Variants & Pathogenicity by Type

Statistics based on transcript NM_024786.3. Only rare variants are included.

We include only reliable ClinVar variants with their consequences to MANE Select, MANE Plus Clinical transcripts, or transcripts with TSL equal to 1. Click a count to filter the variants table below.

Slight differences between displayed counts and ClinVar may occur due to a different transcript/consequence chosen by our variant effect predictor, or because we classify Benign/Likely benign as Likely benign and Pathogenic/Likely pathogenic as Likely pathogenic.

Effect	PathogenicP	Likely pathogenicLP	VUS	Likely benignLB	BenignB	Sum
synonymous			1 clinvar	3 clinvar		4
missense			103 clinvar	14 clinvar	1 clinvar	118
nonsense			1 clinvar			1
start loss						0
frameshift						0
splice donor/acceptor (+/-2bp)			1 clinvar			1
Total	0	0	106	17	1	124

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Transcript Catalog

Annotated transcript isoforms across RefSeq and Ensembl databases

Showing 4 of 34 transcripts

Transcript ID	Source	Protein ID	Coding Exons	MANE Status
NM_024786.3	RefSeq	NP_079062.1	12	MANE Select
ENST00000283441.13	Ensembl	ENSP00000283441.8	12	MANE Select
NM_001393492.1	RefSeq	NP_001380421.1	12	Standard
ENST00000507800.1	Ensembl	ENSP00000423817.1	7	Standard

Gene Ontology (GO) Annotations & Pathways

Biological processes, molecular functions, cellular components and pathways

Biological Process

protein targeting to membrane
peptidyl-L-cysteine S-palmitoylation

Molecular Function

protein-cysteine S-palmitoyltransferase activity

Cellular Component

endoplasmic reticulum
Golgi apparatus
integral component of membrane

gnomAD Constraint

Source: gnomAD

Gene type: protein_coding
Transcript type: protein_coding
Transcript: ENST00000283441
Coding exons: 12
Length: 140631
Individuals with no LoFs: 125654
Homozygous LoFs: 0
Heterozygous LoFs: 94
Defined: 125748
p: 0.000374

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible
Missense	-0.918	259	221	1.17	0.0000131	2605
Missense (PolyPhen)		38	40.592	0.93615		530
Synonymous	-2.22	128	99.8	1.28	0.00000714	771
Loss of Function	-0.338	22	20.4	1.08	8.67e-7	257

Population LoF Frequency

Population	CAF	p-value	Status
African	0.00056	0.00055	rare
Latino/Admixed American	0.00038	0.00038	rare
Ashkenazi Jewish	0	0.0	absent
East Asian	0.0025	0.0017	notable
Finnish	0	0.0	absent
European (Non-Finnish)	0.00028	0.00025	rare
South Asian	0.00040	0.00036	rare
Other	0.00041	0.00033	rare

dbNSFP Gene Annotations

Source: dbNSFP

Intolerance Scores

LoFtool: 0.978
RVIS EVS: 0.98
RVIS percentile EVS: 90.43

Essentials

Essential (CRISPR): N
Essential (CRISPR2): N
Essential (gene trap): N
Indispensability pred.: E
Indispensability score: 0.683

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	Medium	Medium	Medium
Primary Immunodeficiency	Medium	Medium	Medium
Cancer	Medium	Medium	Medium