ZFTA

protein-coding

zinc finger translocation associated, the group of Zinc fingers C2H2-type

Gene summary

Predicted to be involved in negative regulation of DNA-templated transcription. Located in nucleus. [provided by Alliance of Genome Resources, Jun 2026]

Previous symbols:

C11orf95

MANE transcript

NM_001144936.2

Inheritance

—

ClinVar variants

U:10B:3

Top phenotype

—

Max pathogenic AF

—

Genomic locus

chr11:63,759,892-63,768,775

External References & Databases

Ensembl (ENSG00000188070)

Transcript & Mutation Effects

hg38 • Region Span ~8.9 kb

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GenCC Phenotypes & Disease Associations

Curated gene-disease validity assertions and inheritance patterns

No GenCC data available for this gene.

ClinVar Associated Diseases & Phenotypes

Reported disease conditions connected to ZFTA variants in ClinVar

2 Conditions Cataloged

not specifiedTotal: 9

not providedTotal: 3

ClinVar Variants & Pathogenicity by Type

Statistics based on transcript NM_001144936.2. Only rare variants are included.

We include only reliable ClinVar variants with their consequences to MANE Select, MANE Plus Clinical transcripts, or transcripts with TSL equal to 1. Click a count to filter the variants table below.

Slight differences between displayed counts and ClinVar may occur due to a different transcript/consequence chosen by our variant effect predictor, or because we classify Benign/Likely benign as Likely benign and Pathogenic/Likely pathogenic as Likely pathogenic.

Effect	PathogenicP	Likely pathogenicLP	VUS	Likely benignLB	BenignB	Sum
synonymous				3 clinvar		3
missense			9 clinvar			9
nonsense						0
start loss						0
frameshift						0
splice donor/acceptor (+/-2bp)			1 clinvar			1
Total	0	0	10	3	0	13

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Transcript Catalog

Annotated transcript isoforms across RefSeq and Ensembl databases

Showing 4 of 20 transcripts

Transcript ID	Source	Protein ID	Coding Exons	MANE Status
NM_001144936.2	RefSeq	NP_001138408.1	5	MANE Select
ENST00000433688.2	Ensembl	ENSP00000482180.1	5	MANE Select
ENST00000338498.6	Ensembl	ENSP00000483097.1	2	Standard
ENST00000445014.3	Ensembl	ENSP00000478462.1	4	Standard

Gene Ontology (GO) Annotations & Pathways

Biological processes, molecular functions, cellular components and pathways

Biological Process

negative regulation of transcription, DNA-templated

Molecular Function

nucleic acid binding

dbNSFP Gene Annotations

Source: dbNSFP

Disease: DISEASE: Note=A chromosomal aberration involving MRTFB is found in 3 chondroid lipomas. Translocation t(11;16)(q13;p13) with MRTFB produces a C11orf95-MRTFB fusion protein (PubMed:20607705). {ECO:0000269|PubMed:20607705}.; DISEASE: Note=A chromosomal aberration involving RELA is found in more than two-thirds of supratentorial ependymomas. Translocation with RELA produces a C11orf95-RELA fusion protein. C11orf95-RELA translocations are potent oncogenes that probably transform neural stem cells by driving an aberrant NF-kappa-B transcription program (PubMed:24553141). {ECO:0000269|PubMed:24553141}.;