ZNF155

zinc finger protein 155, the group of Zinc fingers C2H2-type

Basic information

Region (hg38): 19:43967862-43998326

Links

ENSG00000204920 ∙ NCBI:7711 ∙ OMIM:604086 ∙ HGNC:12940 ∙ Uniprot:Q12901 ∙ AlphaFold ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the ZNF155 gene.

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the ZNF155 gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense			32	3		35
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding						0
Total	0	0	32	3	0

Variants in ZNF155

This is a list of pathogenic ClinVar variants found in the ZNF155 region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
19-43988548-C-T		not specified	Uncertain significance (May 03, 2023)
19-43991848-A-G		not specified	Uncertain significance (Nov 09, 2021)
19-43991926-G-A		not specified	Uncertain significance (Nov 18, 2022)
19-43996131-G-A		not specified	Uncertain significance (Mar 17, 2023)
19-43996252-C-T		not specified	Uncertain significance (Mar 20, 2023)
19-43996258-T-C		not specified	Uncertain significance (Mar 07, 2023)
19-43996312-A-G		not specified	Uncertain significance (Feb 05, 2024)
19-43996455-G-A		not specified	Uncertain significance (Dec 17, 2023)
19-43996469-T-G		not specified	Uncertain significance (Apr 26, 2024)
19-43996491-G-A		not specified	Uncertain significance (Jul 08, 2022)
19-43996534-A-G		not specified	Uncertain significance (Mar 24, 2023)
19-43996585-G-A		not specified	Uncertain significance (Dec 22, 2023)
19-43996601-T-A		not specified	Uncertain significance (Jan 26, 2023)
19-43996662-T-C		not specified	Uncertain significance (Oct 10, 2023)
19-43996679-G-T		not specified	Likely benign (Sep 30, 2021)
19-43996699-T-A		not specified	Uncertain significance (Apr 17, 2023)
19-43996707-G-T		not specified	Uncertain significance (Dec 15, 2023)
19-43996734-T-C		not specified	Uncertain significance (Mar 22, 2023)
19-43996800-C-T		not specified	Uncertain significance (Dec 19, 2022)
19-43996855-G-T		not specified	Uncertain significance (Mar 12, 2024)
19-43996893-T-A		not specified	Uncertain significance (Oct 21, 2021)
19-43996899-C-G		not specified	Likely benign (Sep 29, 2023)
19-43996962-G-A		not specified	Uncertain significance (Mar 17, 2023)
19-43997053-G-A		not specified	Uncertain significance (Dec 14, 2021)
19-43997164-G-A		not specified	Uncertain significance (Mar 29, 2023)

GnomAD

Source: gnomAD

Gene	Type	Bio Type	Transcript	Coding Exons	Length
ZNF155	protein_coding	protein_coding	ENST00000407951	4	30464

pLI Probability LOF Intolerant	pRec Probability LOF Recessive	Individuals with no LOFs	Individuals with Homozygous LOFs	Individuals with Heterozygous LOFs	Defined	p
6.62e-7	0.0825	125703	0	37	125740	0.000147

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible in Transcript
Missense	-0.524	303	278	1.09	0.0000137	3657
Missense in Polyphen		97	92.401	1.0498		1301
Synonymous	-1.87	123	99.3	1.24	0.00000468	960
Loss of Function	-1.01	8	5.45	1.47	3.17e-7	60

LoF frequencies by population

Ethnicity	Sum of pLOFs	p
African & African-American	0.000123	0.000123
Ashkenazi Jewish	0.00	0.00
East Asian	0.00125	0.00125
Finnish	0.00	0.00
European (Non-Finnish)	0.0000619	0.0000615
Middle Eastern	0.00125	0.00125
South Asian	0.000131	0.000131
Other	0.000163	0.000163

dbNSFP

Source: dbNSFP

• Function: FUNCTION: May be involved in transcriptional regulation.
• Pathway: Gene expression (Transcription);Generic Transcription Pathway;RNA Polymerase II Transcription (Consensus)

Recessive Scores

• pRec: 0.0887

Intolerance Scores

• rvis_EVS: 0.4
• rvis_percentile_EVS: 76.41

Haploinsufficiency Scores

• pHI: 0.102
• hipred: N
• hipred_score: 0.112
• ghis: 0.454

Essentials

• essential_gene_CRISPR: N
• essential_gene_CRISPR2: N
• essential_gene_gene_trap: N
• gene_indispensability_pred: N
• gene_indispensability_score: 0.210

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	Medium	Medium	Medium
Primary Immunodeficiency	Medium	Medium	Medium
Cancer	Medium	Medium	Medium

Gene ontology

• Biological process: regulation of transcription by RNA polymerase II
• Cellular component: nucleus
• Molecular function: DNA-binding transcription factor activity, RNA polymerase II-specific;DNA binding;DNA-binding transcription factor activity;metal ion binding