ZNF22-AS1

ZNF22 antisense RNA 1, the group of Antisense RNAs

Basic information

Region (hg38): 10:44997697-45236093

Previous symbols: [ "C10orf25" ]

Links

ENSG00000165511 ∙ NCBI:220979 ∙ ∙ HGNC:23509 ∙ Uniprot:Q5T742 ∙ AlphaFold ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the ZNF22-AS1 gene.

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the ZNF22-AS1 gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense						0
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding						0
Total	0	0	0	0	0

Variants in ZNF22-AS1

This is a list of pathogenic ClinVar variants found in the ZNF22-AS1 region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
10-45003390-G-C		not specified	Uncertain significance (Mar 27, 2023)
10-45003393-G-T		not specified	Uncertain significance (Mar 15, 2024)
10-45003477-A-C		not specified	Uncertain significance (May 20, 2024)
10-45003499-G-C		not specified	Uncertain significance (May 26, 2024)
10-45003708-G-A		not specified	Uncertain significance (Feb 25, 2025)
10-45003713-G-C		not specified	Uncertain significance (Jan 29, 2024)
10-45003760-G-A		not specified	Uncertain significance (Apr 08, 2022)
10-45003823-C-T		not specified	Uncertain significance (May 01, 2024)
10-45003870-C-A		not specified	Uncertain significance (Nov 15, 2024)
10-45003930-G-A		not specified	Uncertain significance (Oct 26, 2021)

GnomAD

Source: gnomAD

Gene	Type	Bio Type	Transcript	Coding Exons	Length
ZNF22-AS1	protein_coding	protein_coding	ENST00000298298	2	3191

pLI Probability LOF Intolerant	pRec Probability LOF Recessive	Individuals with no LOFs	Individuals with Homozygous LOFs	Individuals with Heterozygous LOFs	Defined	p
3.71e-7	0.0593	0	0	0	0	0.00

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible in Transcript
Missense	-0.0294	63	62.3	1.01	0.00000292	775
Missense in Polyphen		3	1.9504	1.5381		30
Synonymous	-1.91	34	22.5	1.51	0.00000104	237
Loss of Function	-1.36	8	4.79	1.67	2.12e-7	54

LoF frequencies by population

Ethnicity	Sum of pLOFs	p
African & African-American	0.00	0.00
Ashkenazi Jewish	0.00	0.00
East Asian	0.00	0.00
Finnish	0.00	0.00
European (Non-Finnish)	0.00	0.00
Middle Eastern	0.00	0.00
South Asian	0.00	0.00
Other	0.00	0.00

dbNSFP

Source: dbNSFP

Intolerance Scores

• loftool: 0.726
• rvis_EVS: 0.59
• rvis_percentile_EVS: 82.45

Haploinsufficiency Scores

• pHI: 0.0830
• hipred: N
• hipred_score: 0.146
• ghis: 0.403

Essentials

• essential_gene_CRISPR: N
• essential_gene_CRISPR2: N
• essential_gene_gene_trap: N

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	Medium	Medium	Medium
Primary Immunodeficiency	Medium	Medium	Medium
Cancer	Medium	Medium	Medium

Gene ontology

• Cellular component: extracellular region