ZNF26

zinc finger protein 26, the group of Zinc fingers C2H2-type

Basic information

Region (hg38): 12:132986364-133032952

Links

ENSG00000198393 ∙ NCBI:7574 ∙ OMIM:194537 ∙ HGNC:13053 ∙ Uniprot:P17031 ∙ AlphaFold ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the ZNF26 gene.

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the ZNF26 gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous					1	1
missense			20	1		21
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding						0
Total	0	0	20	1	1

Variants in ZNF26

This is a list of pathogenic ClinVar variants found in the ZNF26 region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
12-133010158-G-C		not specified	Uncertain significance (Nov 12, 2021)
12-133010184-T-C		not specified	Uncertain significance (Feb 17, 2022)
12-133010196-A-G		not specified	Uncertain significance (Jun 27, 2022)
12-133010250-G-A		not specified	Uncertain significance (Oct 26, 2021)
12-133010256-G-A		not specified	Uncertain significance (Jun 09, 2022)
12-133010271-G-A		not specified	Likely benign (Feb 03, 2022)
12-133010367-A-C		not specified	Uncertain significance (Feb 17, 2022)
12-133010560-A-G		EBV-positive nodal T- and NK-cell lymphoma	Likely benign (-)
12-133010655-G-C		not specified	Uncertain significance (Nov 09, 2021)
12-133010666-T-C		not specified	Uncertain significance (Mar 28, 2023)
12-133010747-G-A		not specified	Uncertain significance (Mar 17, 2023)
12-133010862-A-G		not specified	Uncertain significance (Apr 25, 2022)
12-133010960-C-G		not specified	Uncertain significance (Mar 16, 2022)
12-133011020-A-G		not specified	Uncertain significance (Apr 08, 2022)
12-133011101-A-G		not specified	Uncertain significance (Jan 10, 2023)
12-133011117-T-C		not specified	Uncertain significance (Feb 16, 2023)
12-133011162-G-A		not specified	Uncertain significance (Nov 08, 2021)
12-133011315-A-G		not specified	Uncertain significance (Dec 21, 2022)
12-133011333-G-C		not specified	Uncertain significance (Jul 13, 2022)
12-133011380-C-G		not specified	Uncertain significance (Sep 15, 2021)
12-133011394-C-T		not specified	Benign (-)
12-133011449-G-C		not specified	Uncertain significance (Oct 22, 2021)
12-133011460-A-G		not specified	Uncertain significance (Dec 17, 2021)

GnomAD

Source: gnomAD

dbNSFP

Source: dbNSFP

• Function: FUNCTION: May be involved in transcriptional regulation.
• Pathway: Gene expression (Transcription);Generic Transcription Pathway;RNA Polymerase II Transcription (Consensus)

Haploinsufficiency Scores

• pHI: 0.101
• ghis: 0.554

Essentials

• essential_gene_CRISPR: N
• essential_gene_CRISPR2: N
• essential_gene_gene_trap: N
• gene_indispensability_pred: E
• gene_indispensability_score: 0.759

Gene ontology

• Biological process: regulation of transcription by RNA polymerase II
• Cellular component: nucleus
• Molecular function: DNA-binding transcription factor activity, RNA polymerase II-specific;DNA binding;protein binding;metal ion binding