ZNF266

zinc finger protein 266, the group of Zinc fingers C2H2-type

Basic information

Region (hg38): 19:9412429-9435573

Links

ENSG00000174652 ∙ NCBI:10781 ∙ OMIM:604751 ∙ HGNC:13059 ∙ Uniprot:Q14584 ∙ AlphaFold ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the ZNF266 gene.

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the ZNF266 gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense			35			35
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding						0
Total	0	0	35	0	0

Variants in ZNF266

This is a list of pathogenic ClinVar variants found in the ZNF266 region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
19-9413288-C-T		not specified	Uncertain significance (May 20, 2024)
19-9413313-G-T		not specified	Uncertain significance (Dec 16, 2023)
19-9413361-A-G		not specified	Uncertain significance (Nov 09, 2023)
19-9413474-C-T		not specified	Uncertain significance (Aug 12, 2022)
19-9413525-A-G		not specified	Uncertain significance (Nov 27, 2023)
19-9413535-A-T		not specified	Uncertain significance (Jun 30, 2022)
19-9413562-T-C		not specified	Uncertain significance (Apr 08, 2024)
19-9413585-T-C		not specified	Uncertain significance (Nov 14, 2023)
19-9413603-C-T		not specified	Uncertain significance (Jan 17, 2023)
19-9413609-A-G		not specified	Uncertain significance (Apr 23, 2024)
19-9413648-T-C		not specified	Uncertain significance (Jul 06, 2021)
19-9413835-T-A		not specified	Uncertain significance (Aug 12, 2022)
19-9413878-T-C		not specified	Uncertain significance (Jan 23, 2024)
19-9413903-T-C		not specified	Uncertain significance (May 24, 2023)
19-9413988-C-T		not specified	Uncertain significance (Nov 12, 2021)
19-9414003-A-T		not specified	Uncertain significance (Sep 16, 2021)
19-9414068-T-C		not specified	Uncertain significance (Jul 13, 2021)
19-9414080-C-T		not specified	Uncertain significance (Jul 12, 2022)
19-9414090-C-G		not specified	Uncertain significance (Apr 01, 2024)
19-9414120-T-C		not specified	Uncertain significance (Feb 08, 2023)
19-9414225-G-A		not specified	Uncertain significance (Jun 18, 2024)
19-9414236-T-C		not specified	Uncertain significance (Jun 29, 2023)
19-9414341-T-C		not specified	Uncertain significance (Nov 03, 2022)
19-9414348-A-C		not specified	Uncertain significance (Jul 13, 2022)
19-9414441-C-T		not specified	Uncertain significance (Dec 21, 2022)

GnomAD

Source: gnomAD

Gene	Type	Bio Type	Transcript	Coding Exons	Length
ZNF266	protein_coding	protein_coding	ENST00000592904	4	22983

pLI Probability LOF Intolerant	pRec Probability LOF Recessive	Individuals with no LOFs	Individuals with Homozygous LOFs	Individuals with Heterozygous LOFs	Defined	p
0.0229	0.781	125738	0	7	125745	0.0000278

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible in Transcript
Missense	-0.418	310	290	1.07	0.0000141	3645
Missense in Polyphen		97	86.567	1.1205		1058
Synonymous	-0.380	110	105	1.05	0.00000538	996
Loss of Function	0.939	3	5.34	0.562	2.27e-7	61

LoF frequencies by population

Ethnicity	Sum of pLOFs	p
African & African-American	0.00	0.00
Ashkenazi Jewish	0.00	0.00
East Asian	0.00	0.00
Finnish	0.00	0.00
European (Non-Finnish)	0.0000542	0.0000527
Middle Eastern	0.00	0.00
South Asian	0.0000327	0.0000327
Other	0.00	0.00

dbNSFP

Source: dbNSFP

• Function: FUNCTION: May be involved in transcriptional regulation.
• Pathway: Gene expression (Transcription);Generic Transcription Pathway;RNA Polymerase II Transcription (Consensus)

Intolerance Scores

• loftool: 0.166
• rvis_EVS: -0.35
• rvis_percentile_EVS: 29.43

Haploinsufficiency Scores

• pHI: 0.128
• hipred: N
• hipred_score: 0.112
• ghis: 0.552

Essentials

• essential_gene_CRISPR: N
• essential_gene_CRISPR2: N
• gene_indispensability_pred: E
• gene_indispensability_score: 0.608

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	Medium	Medium	Medium
Primary Immunodeficiency	Medium	Medium	Medium
Cancer	Medium	Medium	Medium

Mouse Genome Informatics

• Gene name: Zfp266
• Phenotype: immune system phenotype; mortality/aging (the observable characteristics related to the ability of a mammalian organism to live and age that are manifested throughout development and life span); hematopoietic system phenotype

Gene ontology

• Biological process: regulation of transcription by RNA polymerase II
• Cellular component: nucleus
• Molecular function: DNA-binding transcription factor activity, RNA polymerase II-specific;DNA binding;protein binding;metal ion binding