ZNF277

protein-coding

zinc finger protein 277, the group of Zinc fingers C2H2-type

Gene summary

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jun 2026]

Previous symbols:

ZNF277P

MANE transcript

NM_021994.3

Inheritance

—

ClinVar variants

U:49B:7

Top phenotype

—

gnomAD constraint

pLI —, LoF o/e 1.15

Max pathogenic AF

—

Genomic locus

chr7:112,206,695-112,343,934

External References & Databases

Ensembl (ENSG00000198839)

Transcript & Mutation Effects

hg38 • Region Span ~137.2 kb

Loading mutation effect viewer...

GenCC Phenotypes & Disease Associations

Curated gene-disease validity assertions and inheritance patterns

No GenCC data available for this gene.

ClinVar Associated Diseases & Phenotypes

Reported disease conditions connected to ZNF277 variants in ClinVar

2 Conditions Cataloged

not specifiedTotal: 47

not providedTotal: 7

ClinVar Variants & Pathogenicity by Type

Statistics based on transcript NM_021994.3. Only rare variants are included.

We include only reliable ClinVar variants with their consequences to MANE Select, MANE Plus Clinical transcripts, or transcripts with TSL equal to 1. Click a count to filter the variants table below.

Slight differences between displayed counts and ClinVar may occur due to a different transcript/consequence chosen by our variant effect predictor, or because we classify Benign/Likely benign as Likely benign and Pathogenic/Likely pathogenic as Likely pathogenic.

Effect	PathogenicP	Likely pathogenicLP	VUS	Likely benignLB	BenignB	Sum
synonymous			1 clinvar	3 clinvar		4
missense			44 clinvar	3 clinvar		47
nonsense						0
start loss						0
frameshift					1 clinvar	1
splice donor/acceptor (+/-2bp)			4 clinvar			4
Total	0	0	49	6	1	56

Loading ClinVar variants...

Transcript Catalog

Annotated transcript isoforms across RefSeq and Ensembl databases

Showing 4 of 32 transcripts

Transcript ID	Source	Protein ID	Coding Exons	MANE Status
NM_021994.3	RefSeq	NP_068834.2	12	MANE Select
ENST00000361822.8	Ensembl	ENSP00000354501.3	12	MANE Select
ENST00000361946.8	Ensembl	ENSP00000355043.4	2	Standard
ENST00000421043.5	Ensembl	ENSP00000410538.1	2	Standard

Gene Ontology (GO) Annotations & Pathways

Biological processes, molecular functions, cellular components and pathways

Biological Process

regulation of transcription by RNA polymerase II
cellular response to hydrogen peroxide
regulation of cellular senescence

Molecular Function

RNA polymerase II proximal promoter sequence-specific DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific
metal ion binding

Cellular Component

nucleus

gnomAD Constraint

Source: gnomAD

Gene type: protein_coding
Transcript type: protein_coding
Transcript: ENST00000361822
Coding exons: 12
Length: 136509
Individuals with no LoFs: 124745
Homozygous LoFs: 16
Heterozygous LoFs: 987
Defined: 125748
p: 0.00400

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible
Missense	0.347	213	228	0.935	0.0000107	3014
Missense (PolyPhen)		70	71.199	0.98317		991
Synonymous	0.104	82	83.2	0.985	0.00000434	752
Loss of Function	-0.704	30	26.1	1.15	0.00000121	334

Population LoF Frequency

Population	CAF	p-value	Status
African	0.0025	0.0025	notable
Latino/Admixed American	0.024	0.024	notable
Ashkenazi Jewish	0.00030	0.00030	rare
East Asian	0.00082	0.00082	rare
Finnish	0.0024	0.0024	notable
European (Non-Finnish)	0.00033	0.00033	rare
South Asian	0.00049	0.00049	rare
Other	0.0028	0.0028	notable

dbNSFP Gene Annotations

Source: dbNSFP

Function: FUNCTION: May be involved in transcriptional regulation.;

Recessive Scores

pRec: 0.105

Intolerance Scores

LoFtool: 0.917
RVIS EVS: 0
RVIS percentile EVS: 53.73

Essentials

Essential (CRISPR): N
Essential (CRISPR2): N
Essential (gene trap): N
Indispensability pred.: E
Indispensability score: 0.975

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	Medium	Medium	Medium
Primary Immunodeficiency	Medium	Medium	Medium
Cancer	Medium	Medium	Medium