ZNF358

zinc finger protein 358, the group of Zinc fingers C2H2-type

Basic information

Region (hg38): 19:7515292-7521025

Links

ENSG00000198816 ∙ NCBI:140467 ∙ OMIM:619496 ∙ HGNC:16838 ∙ Uniprot:Q9NW07 ∙ AlphaFold ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the ZNF358 gene.

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the ZNF358 gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous				3	2	5
missense			33	2		35
nonsense						0
start loss						0
frameshift						0
inframe indel				1		1
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding						0
Total	0	0	33	6	2

Variants in ZNF358

This is a list of pathogenic ClinVar variants found in the ZNF358 region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
19-7519250-G-A		not specified	Uncertain significance (Jul 20, 2021)
19-7519261-G-C		not specified	Uncertain significance (Jul 14, 2023)
19-7519271-C-G		not specified	Uncertain significance (Jun 17, 2024)
19-7519289-G-A		not specified	Uncertain significance (Dec 14, 2023)
19-7519291-C-A		not specified	Uncertain significance (Apr 27, 2023)
19-7519294-G-A		not specified	Uncertain significance (Oct 17, 2023)
19-7519349-T-C		not specified	Uncertain significance (Jun 12, 2023)
19-7519353-C-T			Benign (Mar 29, 2018)
19-7519430-A-T		not specified	Uncertain significance (Oct 26, 2022)
19-7519443-C-G			Benign (May 02, 2018)
19-7519468-G-A		not specified	Uncertain significance (Apr 08, 2022)
19-7519495-C-T		not specified	Uncertain significance (Dec 15, 2022)
19-7519502-C-T		not specified	Uncertain significance (Apr 04, 2023)
19-7519511-C-T		EBV-positive nodal T- and NK-cell lymphoma	Likely benign (-)
19-7519587-C-T			Likely benign (Oct 01, 2022)
19-7519603-G-T		not specified	Uncertain significance (Aug 02, 2021)
19-7519619-G-A		not specified	Likely benign (Jul 14, 2021)
19-7519646-C-T		not specified	Uncertain significance (Sep 06, 2022)
19-7519718-C-A		not specified	Uncertain significance (Apr 30, 2024)
19-7519724-G-T		not specified	Uncertain significance (Nov 27, 2023)
19-7519726-C-G		not specified	Uncertain significance (Mar 26, 2024)
19-7519731-C-G		not specified	Uncertain significance (Apr 20, 2024)
19-7519780-C-A		not specified	Uncertain significance (Jan 16, 2024)
19-7519812-C-G		not specified	Uncertain significance (Aug 02, 2023)
19-7519955-C-T		not specified	Uncertain significance (Jan 19, 2022)

GnomAD

Source: gnomAD

Gene	Type	Bio Type	Transcript	Coding Exons	Length
ZNF358	protein_coding	protein_coding	ENST00000597229	1	5735

pLI Probability LOF Intolerant	pRec Probability LOF Recessive	Individuals with no LOFs	Individuals with Homozygous LOFs	Individuals with Heterozygous LOFs	Defined	p
0.788	0.211	125731	0	4	125735	0.0000159

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible in Transcript
Missense	2.58	239	381	0.628	0.0000270	3623
Missense in Polyphen		75	192.07	0.39049		1714
Synonymous	0.0444	180	181	0.996	0.0000146	1260
Loss of Function	2.55	1	9.48	0.105	4.77e-7	102

LoF frequencies by population

Ethnicity	Sum of pLOFs	p
African & African-American	0.00	0.00
Ashkenazi Jewish	0.00	0.00
East Asian	0.00	0.00
Finnish	0.00	0.00
European (Non-Finnish)	0.0000271	0.0000264
Middle Eastern	0.00	0.00
South Asian	0.0000327	0.0000327
Other	0.00	0.00

dbNSFP

Source: dbNSFP

• Function: FUNCTION: May be involved in transcriptional regulation.

Intolerance Scores

• rvis_EVS: 0.44
• rvis_percentile_EVS: 77.8

Haploinsufficiency Scores

• pHI: 0.186
• hipred: Y
• hipred_score: 0.622
• ghis: 0.506

Essentials

• essential_gene_CRISPR: N
• essential_gene_CRISPR2: N
• gene_indispensability_pred: E
• gene_indispensability_score: 0.547

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	Medium	Medium	Medium
Primary Immunodeficiency	Medium	Medium	Medium
Cancer	Medium	Medium	Medium

Mouse Genome Informatics

• Gene name: Zfp358

Gene ontology

• Biological process: regulation of transcription by RNA polymerase II;stem cell population maintenance;neural tube development;embryonic forelimb morphogenesis
• Cellular component: nucleus
• Molecular function: DNA-binding transcription factor activity, RNA polymerase II-specific;DNA binding;metal ion binding