ZNF735

zinc finger protein 735, the group of Zinc fingers C2H2-type

Basic information

Region (hg38): 7:64207203-64220290

Previous symbols: [ "ZNF735P" ]

Links

ENSG00000223614 ∙ NCBI:730291 ∙ ∙ HGNC:32466 ∙ Uniprot:P0CB33 ∙ AlphaFold ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the ZNF735 gene.

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the ZNF735 gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense			37	6		43
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding						0
Total	0	0	37	6	0

Variants in ZNF735

This is a list of pathogenic ClinVar variants found in the ZNF735 region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
7-64213134-G-T		not specified	Uncertain significance (Oct 12, 2024)
7-64213135-C-A		not specified	Uncertain significance (Sep 26, 2024)
7-64213135-C-T		not specified	Uncertain significance (Aug 20, 2024)
7-64213155-C-A		not specified	Uncertain significance (Nov 27, 2023)
7-64213165-A-G		not specified	Uncertain significance (Jun 02, 2023)
7-64213209-T-G		not specified	Likely benign (Mar 17, 2023)
7-64213210-T-G		not specified	Uncertain significance (Jun 05, 2023)
7-64214042-G-A		not specified	Likely benign (Jun 29, 2022)
7-64214094-C-T		not specified	Likely benign (Nov 24, 2024)
7-64219326-A-G		not specified	Uncertain significance (Oct 25, 2024)
7-64219337-G-T		not specified	Uncertain significance (Nov 07, 2024)
7-64219382-A-G		not specified	Uncertain significance (Oct 20, 2023)
7-64219392-C-T		not specified	Uncertain significance (Jan 04, 2024)
7-64219469-G-A		not specified	Uncertain significance (Nov 13, 2024)
7-64219509-A-C		not specified	Uncertain significance (Jan 24, 2024)
7-64219580-G-A		not specified	Likely benign (Oct 12, 2024)
7-64219595-A-C		not specified	Uncertain significance (Jan 16, 2024)
7-64219637-A-G		not specified	Uncertain significance (Nov 08, 2024)
7-64219731-G-A		not specified	Likely benign (Dec 17, 2021)
7-64219733-G-A		not specified	Uncertain significance (May 18, 2023)
7-64219739-A-G		not specified	Uncertain significance (Jul 22, 2024)
7-64219749-G-T		not specified	Uncertain significance (Jan 17, 2023)
7-64219787-T-C		not specified	Uncertain significance (Nov 10, 2022)
7-64219802-A-T		not specified	Uncertain significance (Sep 23, 2023)
7-64219808-C-T		not specified	Likely benign (Dec 06, 2022)

GnomAD

Source: gnomAD

dbNSFP

Source: dbNSFP

• Function: FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
• Pathway: Gene expression (Transcription);Generic Transcription Pathway;RNA Polymerase II Transcription (Consensus)

Gene ontology

• Biological process: regulation of transcription, DNA-templated
• Cellular component: nucleus
• Molecular function: DNA binding;metal ion binding