ZNF766

protein-coding

zinc finger protein 766, the group of Zinc fingers C2H2-type|MicroRNA protein coding host genes

Gene summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in centrosome. [provided by Alliance of Genome Resources, Jun 2026]

MANE transcript

NM_001010851.3

Inheritance

—

ClinVar variants

U:60

Top phenotype

Hypercalcemia, infantile, 1

gnomAD constraint

pLI —, LoF o/e 1.2

Max pathogenic AF

—

Genomic locus

chr19:52,269,587-52,296,046

External References & Databases

Ensembl (ENSG00000196214)

Transcript & Mutation Effects

hg38 • Region Span ~26.5 kb

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GenCC Phenotypes & Disease Associations

Curated gene-disease validity assertions and inheritance patterns

No GenCC data available for this gene.

ClinVar Associated Diseases & Phenotypes

Reported disease conditions connected to ZNF766 variants in ClinVar

3 Conditions Cataloged

not specifiedTotal: 55

not providedTotal: 1

Hypercalcemia, infantile, 1Total: 1

ClinVar Variants & Pathogenicity by Type

Statistics based on transcript NM_001010851.3. Only rare variants are included.

We include only reliable ClinVar variants with their consequences to MANE Select, MANE Plus Clinical transcripts, or transcripts with TSL equal to 1. Click a count to filter the variants table below.

Slight differences between displayed counts and ClinVar may occur due to a different transcript/consequence chosen by our variant effect predictor, or because we classify Benign/Likely benign as Likely benign and Pathogenic/Likely pathogenic as Likely pathogenic.

Effect	PathogenicP	Likely pathogenicLP	VUS	Likely benignLB	BenignB	Sum
synonymous			1 clinvar			1
missense			58 clinvar			58
nonsense						0
start loss						0
frameshift						0
splice donor/acceptor (+/-2bp)			1 clinvar			1
Total	0	0	60	0	0	60

Loading ClinVar variants...

Transcript Catalog

Annotated transcript isoforms across RefSeq and Ensembl databases

Showing 4 of 18 transcripts

Transcript ID	Source	Protein ID	Coding Exons	MANE Status
NM_001010851.3	RefSeq	NP_001010851.1	4	MANE Select
ENST00000439461.6	Ensembl	ENSP00000409652.1	4	MANE Select
ENST00000593612.1	Ensembl	ENSP00000468950.1	5	Standard
ENST00000593612.2	Ensembl	ENSP00000468950.1	5	Standard

Gene Ontology (GO) Annotations & Pathways

Biological processes, molecular functions, cellular components and pathways

Biological Process

regulation of transcription by RNA polymerase II

Molecular Function

DNA-binding transcription factor activity, RNA polymerase II-specific
DNA binding
metal ion binding

Cellular Component

nucleus

gnomAD Constraint

Source: gnomAD

Gene type: protein_coding
Transcript type: protein_coding
Transcript: ENST00000439461
Coding exons: 4
Length: 23154
Individuals with no LoFs: 124920
Homozygous LoFs: 0
Heterozygous LoFs: 7
Defined: 124927
p: 0.0000280

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible
Missense	0.113	238	243	0.980	0.0000112	3111
Missense (PolyPhen)		64	78.424	0.81608		1068
Synonymous	-0.0372	87	86.6	1.01	0.00000419	825
Loss of Function	-0.448	7	5.83	1.20	2.56e-7	66

Population LoF Frequency

Population	CAF	p-value	Status
African	0.000065	0.000065	rare
Latino/Admixed American	0.000029	0.000029	rare
Ashkenazi Jewish	0	0.0	absent
East Asian	0.00011	0.00011	rare
Finnish	0	0.0	absent
European (Non-Finnish)	0.000020	0.000018	rare
South Asian	0.000033	0.000033	rare
Other	0	0.0	absent

dbNSFP Gene Annotations

Source: dbNSFP

Function: FUNCTION: May be involved in transcriptional regulation.;

Intolerance Scores

LoFtool: 0.876
RVIS EVS: -0.51
RVIS percentile EVS: 21.65

Essentials

Essential (CRISPR): N
Essential (CRISPR2): N
Essential (gene trap): N
Indispensability pred.: N
Indispensability score: 0.337

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	Medium	Medium	Medium
Primary Immunodeficiency	Medium	Medium	Medium
Cancer	Medium	Medium	Medium