ZNF77

protein-coding

zinc finger protein 77, the group of Zinc fingers C2H2-type

Gene summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

MANE transcript

NM_021217.3

Inheritance

—

ClinVar variants

U:115B:7

Top phenotype

—

gnomAD constraint

pLI —, LoF o/e 0.7

Max pathogenic AF

—

Genomic locus

chr19:2,933,218-2,944,971

External References & Databases

Ensembl (ENSG00000175691)

Transcript & Mutation Effects

hg38 • Region Span ~11.8 kb

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GenCC Phenotypes & Disease Associations

Curated gene-disease validity assertions and inheritance patterns

No GenCC data available for this gene.

ClinVar Associated Diseases & Phenotypes

Reported disease conditions connected to ZNF77 variants in ClinVar

2 Conditions Cataloged

not specifiedTotal: 116

not providedTotal: 4

ClinVar Variants & Pathogenicity by Type

Statistics based on transcript NM_021217.3. Only rare variants are included.

We include only reliable ClinVar variants with their consequences to MANE Select, MANE Plus Clinical transcripts, or transcripts with TSL equal to 1. Click a count to filter the variants table below.

Slight differences between displayed counts and ClinVar may occur due to a different transcript/consequence chosen by our variant effect predictor, or because we classify Benign/Likely benign as Likely benign and Pathogenic/Likely pathogenic as Likely pathogenic.

Effect	PathogenicP	Likely pathogenicLP	VUS	Likely benignLB	BenignB	Sum
synonymous				2 clinvar	1 clinvar	3
missense			114 clinvar	2 clinvar	1 clinvar	117
nonsense					1 clinvar	1
start loss						0
frameshift						0
splice donor/acceptor (+/-2bp)			1 clinvar			1
Total	0	0	115	4	3	122

Loading ClinVar variants...

Transcript Catalog

Annotated transcript isoforms across RefSeq and Ensembl databases

Showing 4 of 10 transcripts

Transcript ID	Source	Protein ID	Coding Exons	MANE Status
NM_021217.3	RefSeq	NP_067040.1	4	MANE Select
ENST00000314531.5	Ensembl	ENSP00000319053.3	4	MANE Select
NM_001426550.1	RefSeq	NP_001413479.1	1	Standard
ENST00000863233.1	Ensembl	ENSP00000533292.1	4	Standard

Gene Ontology (GO) Annotations & Pathways

Biological processes, molecular functions, cellular components and pathways

Pathways ConsensusPathDB

Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription

Biological Process

regulation of transcription by RNA polymerase II
biological_process

Molecular Function

DNA-binding transcription factor activity, RNA polymerase II-specific
molecular_function
DNA binding
metal ion binding

Cellular Component

nucleus

gnomAD Constraint

Source: gnomAD

Gene type: protein_coding
Transcript type: protein_coding
Transcript: ENST00000314531
Coding exons: 4
Length: 11754
Individuals with no LoFs: 121106
Homozygous LoFs: 89
Heterozygous LoFs: 4551
Defined: 125746
p: 0.0186

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible
Missense	-0.339	330	313	1.05	0.0000174	3595
Missense (PolyPhen)		92	93.113	0.98804		1106
Synonymous	-0.881	135	123	1.10	0.00000815	979
Loss of Function	0.677	4	5.75	0.695	2.43e-7	70

Population LoF Frequency

Population	CAF	p-value	Status
African	0.013	0.013	notable
Latino/Admixed American	0.025	0.024	notable
Ashkenazi Jewish	0.0096	0.0096	notable
East Asian	0.077	0.067	notable
Finnish	0.016	0.016	notable
European (Non-Finnish)	0.016	0.015	notable
South Asian	0.0054	0.0053	notable
Other	0.021	0.020	notable

dbNSFP Gene Annotations

Source: dbNSFP

Function: FUNCTION: May be involved in transcriptional regulation.;

Recessive Scores

pRec: 0.182

Intolerance Scores

LoFtool: 0.958
RVIS EVS: 1.54
RVIS percentile EVS: 95.57

Essentials

Essential (CRISPR): N
Essential (CRISPR2): N
Essential (gene trap): N
Indispensability pred.: E
Indispensability score: 0.552

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	Medium	Medium	Medium
Primary Immunodeficiency	Medium	Medium	Medium
Cancer	Medium	Medium	Medium