ZNF772

protein-coding

zinc finger protein 772, the group of Zinc fingers C2H2-type

Gene summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

MANE transcript

NM_001144068.2

Inheritance

—

ClinVar variants

U:64B:4

Top phenotype

Prostate cancer

gnomAD constraint

pLI —, LoF o/e 0.52

Max pathogenic AF

—

Genomic locus

chr19:57,466,663-57,477,570

External References & Databases

Ensembl (ENSG00000197128)

Transcript & Mutation Effects

hg38 • Region Span ~10.9 kb

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GenCC Phenotypes & Disease Associations

Curated gene-disease validity assertions and inheritance patterns

No GenCC data available for this gene.

ClinVar Associated Diseases & Phenotypes

Reported disease conditions connected to ZNF772 variants in ClinVar

3 Conditions Cataloged

not specifiedTotal: 65

not providedTotal: 1

Prostate cancerTotal: 1

ClinVar Variants & Pathogenicity by Type

Statistics based on transcript NM_001144068.2. Only rare variants are included.

We include only reliable ClinVar variants with their consequences to MANE Select, MANE Plus Clinical transcripts, or transcripts with TSL equal to 1. Click a count to filter the variants table below.

Slight differences between displayed counts and ClinVar may occur due to a different transcript/consequence chosen by our variant effect predictor, or because we classify Benign/Likely benign as Likely benign and Pathogenic/Likely pathogenic as Likely pathogenic.

Effect	PathogenicP	Likely pathogenicLP	VUS	Likely benignLB	BenignB	Sum
synonymous			1 clinvar			1
missense			59 clinvar	4 clinvar		63
nonsense			1 clinvar			1
start loss						0
frameshift						0
splice donor/acceptor (+/-2bp)			3 clinvar			3
Total	0	0	64	4	0	68

Loading ClinVar variants...

Transcript Catalog

Annotated transcript isoforms across RefSeq and Ensembl databases

Showing 4 of 24 transcripts

Transcript ID	Source	Protein ID	Coding Exons	MANE Status
NM_001144068.2	RefSeq	NP_001137540.1	4	MANE Select
ENST00000356584.8	Ensembl	ENSP00000348992.3	4	MANE Select
NM_001024596.3	RefSeq	NP_001019767.1	5	Standard
NM_001330613.2	RefSeq	NP_001317542.1	1	Standard

Gene Ontology (GO) Annotations & Pathways

Biological processes, molecular functions, cellular components and pathways

Pathways ConsensusPathDB

Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription

Biological Process

regulation of transcription by RNA polymerase II

Molecular Function

DNA-binding transcription factor activity, RNA polymerase II-specific
DNA binding
protein binding
metal ion binding

Cellular Component

nucleus

gnomAD Constraint

Source: gnomAD

Gene type: protein_coding
Transcript type: protein_coding
Transcript: ENST00000343280
Coding exons: 5
Length: 10908
Individuals with no LoFs: 124050
Homozygous LoFs: 8
Heterozygous LoFs: 1690
Defined: 125748
p: 0.00677

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible
Missense	0.487	242	264	0.916	0.0000127	3291
Missense (PolyPhen)		96	111.09	0.86414		1425
Synonymous	0.698	81	89.4	0.906	0.00000442	863
Loss of Function	1.84	9	17.2	0.522	7.41e-7	233

Population LoF Frequency

Population	CAF	p-value	Status
African	0.0015	0.0015	notable
Latino/Admixed American	0.0023	0.0023	notable
Ashkenazi Jewish	0.0082	0.0081	notable
East Asian	0.00054	0.00054	rare
Finnish	0.027	0.027	notable
European (Non-Finnish)	0.0074	0.0074	notable
South Asian	0.0018	0.0018	notable
Other	0.0052	0.0052	notable

dbNSFP Gene Annotations

Source: dbNSFP

Function: FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.;

Intolerance Scores

LoFtool: 0.506
RVIS EVS: 0.28
RVIS percentile EVS: 71.41

Essentials

Essential (CRISPR): N
Essential (CRISPR2): N
Essential (gene trap): N
Indispensability pred.: N
Indispensability score: 0.113

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	Medium	Medium	Medium
Primary Immunodeficiency	Medium	Medium	Medium
Cancer	Medium	Medium	Medium