ZSCAN26

zinc finger and SCAN domain containing 26, the group of Zinc fingers C2H2-type|SCAN domain containing

Basic information

Region (hg38): 6:28267057-28278224

Previous symbols: [ "ZNF187" ]

Links

ENSG00000197062 ∙ NCBI:7741 ∙ OMIM:616474 ∙ HGNC:12978 ∙ Uniprot:Q16670 ∙ AlphaFold ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the ZSCAN26 gene.

• Inborn genetic diseases (4 variants)

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the ZSCAN26 gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense			4			4
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding						0
Total	0	0	4	0	0

Variants in ZSCAN26

This is a list of pathogenic ClinVar variants found in the ZSCAN26 region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
6-28272131-G-A		not specified	Uncertain significance (Sep 27, 2021)
6-28276609-A-T		not specified	Uncertain significance (Nov 10, 2021)
6-28276780-C-A		not specified	Uncertain significance (Mar 06, 2023)
6-28276799-C-T		not specified	Likely benign (Mar 08, 2024)
6-28276948-C-G		not specified	Uncertain significance (Feb 21, 2024)
6-28276985-A-G		not specified	Likely benign (Feb 21, 2024)
6-28277049-G-A		not specified	Uncertain significance (Aug 17, 2022)

GnomAD

Source: gnomAD

dbNSFP

Source: dbNSFP

• Function: FUNCTION: May be involved in transcriptional regulation. {ECO:0000305}.

Recessive Scores

• pRec: 0.0742

Haploinsufficiency Scores

• pHI: 0.0617

Mouse Genome Informatics

• Gene name: Zscan26

Gene ontology

• Biological process: regulation of transcription, DNA-templated;myelination;negative regulation of transcription, DNA-templated
• Cellular component: nucleus;nucleoplasm;cytosol
• Molecular function: nucleic acid binding;DNA-binding transcription factor activity;protein binding;metal ion binding