17-1467445-C-T
Variant summary
Our verdict is Benign. Variant got -20 ACMG points: 0P and 20B. BP4_StrongBP6_Very_StrongBA1
The NM_001080779.2(MYO1C):c.3065+35G>A variant causes a intron change involving the alteration of a non-conserved nucleotide. The variant allele was found at a frequency of 0.0399 in 1,608,666 control chromosomes in the GnomAD database, including 1,804 homozygotes. In-silico tool predicts a benign outcome for this variant. Variant has been reported in ClinVar as Benign (★★).
Frequency
Consequence
NM_001080779.2 intron
Scores
Clinical Significance
Conservation
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ACMG classification
Verdict is Benign. Variant got -20 ACMG points.
Transcripts
RefSeq
Ensembl
Frequencies
GnomAD3 genomes AF: 0.0634 AC: 9622AN: 151862Hom.: 463 Cov.: 30
GnomAD3 exomes AF: 0.0395 AC: 9638AN: 244164Hom.: 290 AF XY: 0.0384 AC XY: 5109AN XY: 133034
GnomAD4 exome AF: 0.0375 AC: 54556AN: 1456686Hom.: 1339 Cov.: 34 AF XY: 0.0378 AC XY: 27389AN XY: 724882
GnomAD4 genome AF: 0.0634 AC: 9641AN: 151980Hom.: 465 Cov.: 30 AF XY: 0.0609 AC XY: 4524AN XY: 74300
ClinVar
Submissions by phenotype
not provided Benign:2
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This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease. -
Computational scores
Source:
Splicing
Find out detailed SpliceAI scores and Pangolin per-transcript scores at