17-43094157-G-C

Variant names:

• chr17-43094157-G-C
• rs879253999
• NM_007294.4:c.1374C>G

Variant summary

Our verdict is Uncertain significance. The variant received 3 ACMG points: 4P and 1B. PM2 PP3_Moderate BP6

The NM_007294.4(BRCA1):​c.1374C>G​(p.Asp458Glu) variant causes a missense change involving the alteration of a non-conserved nucleotide. The variant was absent in control chromosomes in GnomAD project. In-silico tool predicts a pathogenic outcome for this variant. Variant has been reported in ClinVar as Likely benign (no stars). Another nucleotide change resulting in the same amino acid substitution has been previously reported as Likely benign in ClinVar. Another variant affecting the same amino acid position, but resulting in a different missense (i.e. D458V) has been classified as Likely benign.

• Frequency: Genomes: not found (cov: 32)
• Consequence: BRCA1 NM_007294.4 missense
• Clinical Significance: Likely benign no assertion criteria provided B:1
• Conservation: PhyloP100: 0.659
• Publications: 0 publications found

Genes affected

BRCA1 (HGNC:1100): (BRCA1 DNA repair associated) This gene encodes a 190 kD nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The BRCA1 gene contains 22 exons spanning about 110 kb of DNA. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2020]

BRCA1 Gene-Disease associations (from GenCC):

• breast-ovarian cancer, familial, susceptibility to, 1

  Inheritance: AD Classification: DEFINITIVE, STRONG Submitted by: Ambry Genetics, ClinGen, Labcorp Genetics (formerly Invitae), Genomics England PanelApp
• Fanconi anemia, complementation group S

  Inheritance: AR Classification: DEFINITIVE, STRONG, MODERATE, LIMITED Submitted by: G2P, Labcorp Genetics (formerly Invitae), ClinGen, Ambry Genetics
• pancreatic cancer, susceptibility to, 4

  Inheritance: AD Classification: MODERATE Submitted by: Genomics England PanelApp
• hereditary breast ovarian cancer syndrome

  Inheritance: AD Classification: SUPPORTIVE Submitted by: Orphanet
• Fanconi anemia

  Inheritance: AR Classification: SUPPORTIVE Submitted by: Orphanet

ACMG classification

Our verdict: Uncertain_significance. The variant received 3 ACMG points.

• PM2: Very rare variant in population databases, with high coverage
• PP3: MetaRNN computational evidence supports a deleterious effect, 0.874
• BP6: Variant 17-43094157-G-C is Benign according to our data. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars. Variant chr17-43094157-G-C is described in CliVar as Likely_benign. Clinvar id is 2683812.Status of the report is no_assertion_criteria_provided, 0 stars.

Transcripts

RefSeq

Gene	Transcript	HGVSc	HGVSp	Effect	Exon rank	MANE	Protein	UniProt
BRCA1	NM_007294.4	c.1374C>G	p.Asp458Glu	missense_variant	Exon 10 of 23	ENST00000357654.9	NP_009225.1

Ensembl

Gene	Transcript	HGVSc	HGVSp	Effect	Exon rank	TSL	MANE	Protein	Appris	UniProt
BRCA1	ENST00000357654.9	c.1374C>G	p.Asp458Glu	missense_variant	Exon 10 of 23	1	NM_007294.4	ENSP00000350283.3

Frequencies

GnomAD3 genomes Cov.: 32

GnomAD4 exome Cov.: 34

GnomAD4 genome Cov.: 32

ClinVar

Significance: Likely benign

Submissions summary: Benign:1

Revision: no assertion criteria provided

Submissions by phenotype

Breast-ovarian cancer, familial, susceptibility to, 1 Benign:1

Sep 01, 2023

Department of Medical and Surgical Sciences, University of Bologna

Significance: Likely benign

Review Status: no assertion criteria provided

Collection Method: clinical testing

BP1(Strong) according to ACMG/AMP classification guidelines specified for BRCA1 & BRCA2 (Classification Criteria V1.0.0 2023-09-08 - https://cspec.genome.network/cspec/ui/svi/affiliation/50087) (PMID: 38160042) -

Computational scores

Source: dbNSFP v4.3

Name	Calibrated prediction	Score	Prediction
AlphaMissense	Pathogenic	0.72
BayesDel_addAF	Pathogenic	0.34	D
BayesDel_noAF	Pathogenic	0.25
CADD	Benign	18
DANN	Uncertain	0.99
DEOGEN2	Uncertain	0.64	D;.;.;.;T;T;.;.;T
Eigen	Benign	0.045
Eigen_PC	Benign	-0.18
FATHMM_MKL	Benign	0.72	D
LIST_S2	Benign	0.86	D;D;D;D;D;D;D;D;D
M_CAP	Pathogenic	0.51	D
MetaRNN	Pathogenic	0.87	D;D;D;D;D;D;D;D;D
MetaSVM	Uncertain	0.74	D
MutationAssessor	Pathogenic	3.1	M;M;.;.;.;.;.;.;.
PhyloP100		0.66
PrimateAI	Benign	0.45	T
PROVEAN	Uncertain	-4.0	D;D;D;D;.;D;D;D;D
REVEL	Pathogenic	0.69
Sift	Uncertain	0.0070	D;D;D;D;.;D;D;D;D
Sift4G	Benign	0.16	T;T;T;T;.;T;.;D;T
Polyphen		1.0	D;.;.;D;.;.;.;.;.
Vest4		0.68
MutPred		0.67		Gain of helix (P = 0.0078);Gain of helix (P = 0.0078);.;Gain of helix (P = 0.0078);.;Gain of helix (P = 0.0078);.;.;Gain of helix (P = 0.0078);
MVP		0.95
MPC		0.44
ClinPred		0.99	D
GERP RS		-0.56
RBP_binding_hub_radar		0.0
RBP_regulation_power_radar		1.6
Varity_R		0.23
gMVP		0.11
Mutation Taster		=72/28	polymorphism

Splicing

Name	Calibrated prediction	Score	Prediction
SpliceAI score (max)		0.0		Details are displayed if max score is > 0.2

Find out detailed SpliceAI scores and Pangolin per-transcript scores at spliceailookup.broadinstitute.org

Other links and lift over

dbSNP: rs879253999; hg19: chr17-41246174;