17-43097307-A-C

Variant names:

• chr17-43097307-A-C
• rs397507251
• NM_007294.4:c.548-18T>G

Variant summary

Our verdict is Benign. The variant received -12 ACMG points: 0P and 12B. BP4_Strong BP6_Very_Strong

The NM_007294.4(BRCA1):​c.548-18T>G variant causes a intron change involving the alteration of a non-conserved nucleotide. The variant allele was found at a frequency of 0.0000199 in 1,605,130 control chromosomes in the GnomAD database, with no homozygous occurrence. In-silico tool predicts a benign outcome for this variant. Variant has been reported in ClinVar as Likely benign (★★).

• Frequency:
  • Genomes: 𝑓 0.000013 (0 hom., cov: 33)
  • Exomes 𝑓: 0.000021 (0 hom.)
• Consequence: BRCA1 NM_007294.4 intron
• Clinical Significance: Likely benign criteria provided, multiple submitters, no conflicts U:1 B:6
• Conservation: PhyloP100: -0.620
• Publications: 0 publications found

Genes affected

BRCA1 (HGNC:1100): (BRCA1 DNA repair associated) This gene encodes a 190 kD nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The BRCA1 gene contains 22 exons spanning about 110 kb of DNA. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2020]

BRCA1 Gene-Disease associations (from GenCC):

• breast-ovarian cancer, familial, susceptibility to, 1

  Inheritance: AD Classification: DEFINITIVE, STRONG Submitted by: Ambry Genetics, ClinGen, Labcorp Genetics (formerly Invitae), Genomics England PanelApp
• Fanconi anemia, complementation group S

  Inheritance: AR Classification: DEFINITIVE, STRONG, MODERATE, LIMITED Submitted by: G2P, Labcorp Genetics (formerly Invitae), ClinGen, Ambry Genetics
• pancreatic cancer, susceptibility to, 4

  Inheritance: AD Classification: MODERATE Submitted by: Genomics England PanelApp
• hereditary breast ovarian cancer syndrome

  Inheritance: AD Classification: SUPPORTIVE Submitted by: Orphanet
• Fanconi anemia

  Inheritance: AR Classification: SUPPORTIVE Submitted by: Orphanet

ACMG classification

Our verdict: Benign. The variant received -12 ACMG points.

• BP4: Computational evidence support a benign effect (BayesDel_noAF=-0.9).
• BP6: Variant 17-43097307-A-C is Benign according to our data. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars. Variant chr17-43097307-A-C is described in CliVar as Likely_benign. Clinvar id is 37676.Status of the report is criteria_provided_multiple_submitters_no_conflicts, 2 stars.

Transcripts

RefSeq

Gene	Transcript	HGVSc	HGVSp	Effect	Exon rank	MANE	Protein	UniProt
BRCA1	NM_007294.4	c.548-18T>G		intron_variant	Intron 7 of 22	ENST00000357654.9	NP_009225.1

Ensembl

Gene	Transcript	HGVSc	HGVSp	Effect	Exon rank	TSL	MANE	Protein	Appris	UniProt
BRCA1	ENST00000357654.9	c.548-18T>G		intron_variant	Intron 7 of 22	1	NM_007294.4	ENSP00000350283.3

Frequencies

GnomAD3 genomes AF: 0.0000132 AC: 2 AN: 151762 Hom.: 0 Cov.: 33

Gnomad AFR AF: 0.00

Gnomad AMI AF: 0.00

Gnomad AMR AF: 0.0000658

Gnomad ASJ AF: 0.00

Gnomad EAS AF: 0.00

Gnomad SAS AF: 0.00

Gnomad FIN AF: 0.00

Gnomad MID AF: 0.00

Gnomad NFE AF: 0.0000147

Gnomad OTH AF: 0.00

GnomAD2 exomes AF: 0.0000200 AC: 5 AN: 249704 AF XY: 0.0000148

Gnomad AFR exome AF: 0.00

Gnomad AMR exome AF: 0.0000291

Gnomad ASJ exome AF: 0.00

Gnomad EAS exome AF: 0.00

Gnomad FIN exome AF: 0.00

Gnomad NFE exome AF: 0.0000354

Gnomad OTH exome AF: 0.00

GnomAD4 exome AF: 0.0000206 AC: 30 AN: 1453368 Hom.: 0 Cov.: 28 AF XY: 0.0000194 AC XY: 14 AN XY: 723480

African (AFR) AF: 0.00 AC: 0 AN: 33262

American (AMR) AF: 0.00 AC: 0 AN: 44610

Ashkenazi Jewish (ASJ) AF: 0.00 AC: 0 AN: 26084

East Asian (EAS) AF: 0.00 AC: 0 AN: 39606

South Asian (SAS) AF: 0.00 AC: 0 AN: 85916

European-Finnish (FIN) AF: 0.00 AC: 0 AN: 53316

Middle Eastern (MID) AF: 0.00 AC: 0 AN: 5738

European-Non Finnish (NFE) AF: 0.0000263 AC: 29 AN: 1104754

Other (OTH) AF: 0.0000166 AC: 1 AN: 60082

GnomAD4 genome AF: 0.0000132 AC: 2 AN: 151762 Hom.: 0 Cov.: 33 AF XY: 0.0000135 AC XY: 1 AN XY: 74096

African (AFR) AF: 0.00 AC: 0 AN: 41392

American (AMR) AF: 0.0000658 AC: 1 AN: 15190

Ashkenazi Jewish (ASJ) AF: 0.00 AC: 0 AN: 3464

East Asian (EAS) AF: 0.00 AC: 0 AN: 5178

South Asian (SAS) AF: 0.00 AC: 0 AN: 4752

European-Finnish (FIN) AF: 0.00 AC: 0 AN: 10532

Middle Eastern (MID) AF: 0.00 AC: 0 AN: 316

European-Non Finnish (NFE) AF: 0.0000147 AC: 1 AN: 67942

Other (OTH) AF: 0.00 AC: 0 AN: 2086

Alfa AF: 0.00 Hom.: 0

Bravo AF: 0.00000756

ClinVar

Significance: Likely benign

Submissions summary: Uncertain:1 Benign:6

Revision: criteria provided, multiple submitters, no conflicts

Submissions by phenotype

not specified Benign:3

Jan 14, 2017

ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories

Significance: Likely benign

Review Status: criteria provided, single submitter

Collection Method: clinical testing

- -

May 01, 2021

Women's Health and Genetics/Laboratory Corporation of America, LabCorp

Significance: Likely benign

Review Status: criteria provided, single submitter

Collection Method: clinical testing

Variant summary: BRCA1 c.548-18T>G alters a non-conserved nucleotide located close to a canonical splice site and therefore could affect mRNA splicing, leading to a significantly altered protein sequence. 5/5 computational tools predict no significant impact on normal splicing. However, these predictions have yet to be confirmed by functional studies. The variant allele was found at a frequency of 2e-05 in 249704 control chromosomes. The available data on variant occurrences in the general population are insufficient to allow any conclusion about variant significance. To our knowledge, no occurrence of c.548-18T>G in individuals affected with Hereditary Breast And Ovarian Cancer Syndrome and no experimental evidence demonstrating its impact on protein function have been reported. Five clinical diagnostic laboratories have submitted clinical-significance assessments for this variant to ClinVar after 2014 without evidence for independent evaluation. All laboratories classified the variant as likely benign. Based on the evidence outlined above, the variant was classified as likely benign. -

Oct 29, 2015

GeneDx

Significance: Likely benign

Review Status: criteria provided, single submitter

Collection Method: clinical testing

This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease. -

Breast-ovarian cancer, familial, susceptibility to, 1 Uncertain:1 Benign:1

Sep 15, 2016

Counsyl

Significance: Likely benign

Review Status: no assertion criteria provided

Collection Method: clinical testing

This submission and the accompanying classification are no longer maintained by the submitter. For more information on current observations and classification, please contact variantquestions@myriad.com. -

Dec 12, 2007

Sharing Clinical Reports Project (SCRP)

Significance: Uncertain significance

Review Status: no assertion criteria provided

Collection Method: clinical testing

- -

Hereditary cancer-predisposing syndrome Benign:1

Mar 20, 2017

Color Diagnostics, LLC DBA Color Health

Significance: Likely benign

Review Status: criteria provided, single submitter

Collection Method: clinical testing

- -

Hereditary breast ovarian cancer syndrome Benign:1

Feb 03, 2025

Labcorp Genetics (formerly Invitae), Labcorp

Significance: Likely benign

Review Status: criteria provided, single submitter

Collection Method: clinical testing

- -

Computational scores

Source: dbNSFP v4.3

Name	Calibrated prediction	Score	Prediction
BayesDel_noAF	Benign	-0.90
CADD	Benign	0.27
DANN	Benign	0.39
PhyloP100		-0.62

Splicing

Name	Calibrated prediction	Score	Prediction
SpliceAI score (max)		0.010		Details are displayed if max score is > 0.2

Find out detailed SpliceAI scores and Pangolin per-transcript scores at spliceailookup.broadinstitute.org

Other links and lift over

dbSNP: rs397507251; hg19: chr17-41249324;