2-205750342-A-G

Variant names:

• chr2-205750342-A-G
• rs2241155
• NM_003872.3:c.1903+501A>G

Variant summary

Our verdict is Benign. The variant received -12 ACMG points: 0P and 12B. BP4_Strong BA1

The NM_003872.3(NRP2):​c.1903+501A>G variant causes a intron change involving the alteration of a non-conserved nucleotide. The variant allele was found at a frequency of 0.595 in 152,000 control chromosomes in the GnomAD database, including 27,408 homozygotes. In-silico tool predicts a benign outcome for this variant. No clinical diagnostic laboratories have submitted clinical-significance assessments for this variant to ClinVar.

• Frequency: Genomes: 𝑓 0.59 (27408 hom., cov: 32)
• Consequence: NRP2 NM_003872.3 intron
• Clinical Significance: Not reported in ClinVar
• Conservation: PhyloP100: -3.56
• Publications: 4 publications found

Genes affected

NRP2 (HGNC:8005): (neuropilin 2) This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells. [provided by RefSeq, Jul 2021]

ACMG classification

Our verdict: Benign. The variant received -12 ACMG points.

• BP4: Computational evidence support a benign effect (BayesDel_noAF=-0.92).
• BA1: GnomAd4 highest subpopulation (NFE) allele frequency at 95% confidence interval = 0.665 is higher than 0.05.

Variant Effect in Transcripts

ACMG analysis was done for transcript: NM_003872.3. You can select a different transcript below to see updated ACMG assignments.

RefSeq Transcripts

Sel.	Gene	Transcript	Tags	HGVSc	HGVSp	Effect	Exon Rank	Protein	UniProt
	NRP2	NM_003872.3	MANE Select	c.1903+501A>G		intron	N/A	NP_003863.2
	NRP2	NM_201266.2		c.1903+501A>G		intron	N/A	NP_957718.1	O60462-1
	NRP2	NM_201279.2		c.1903+501A>G		intron	N/A	NP_958436.1	O60462-2

Ensembl Transcripts

Sel.	Gene	Transcript	Tags	HGVSc	HGVSp	Effect	Exon Rank	Protein	UniProt
	NRP2	ENST00000357785.10	TSL:1 MANE Select	c.1903+501A>G		intron	N/A	ENSP00000350432.5	O60462-3
	NRP2	ENST00000360409.7	TSL:1	c.1903+501A>G		intron	N/A	ENSP00000353582.3	O60462-1
	NRP2	ENST00000412873.2	TSL:1	c.1903+501A>G		intron	N/A	ENSP00000407626.2	O60462-2

Frequencies

GnomAD3 genomes AF: 0.595 AC: 90331 AN: 151880 Hom.: 27412 Cov.: 32

Gnomad AFR AF: 0.484

Gnomad AMI AF: 0.779

Gnomad AMR AF: 0.608

Gnomad ASJ AF: 0.721

Gnomad EAS AF: 0.523

Gnomad SAS AF: 0.438

Gnomad FIN AF: 0.565

Gnomad MID AF: 0.665

Gnomad NFE AF: 0.670

Gnomad OTH AF: 0.632

We have no GnomAD4 exomes data on this position. Probably position not covered by the project.

GnomAD4 genome AF: 0.595 AC: 90366 AN: 152000 Hom.: 27408 Cov.: 32 AF XY: 0.590 AC XY: 43836 AN XY: 74292

African (AFR) AF: 0.484 AC: 20037 AN: 41440

American (AMR) AF: 0.608 AC: 9288 AN: 15284

Ashkenazi Jewish (ASJ) AF: 0.721 AC: 2501 AN: 3470

East Asian (EAS) AF: 0.522 AC: 2696 AN: 5160

South Asian (SAS) AF: 0.437 AC: 2104 AN: 4812

European-Finnish (FIN) AF: 0.565 AC: 5962 AN: 10548

Middle Eastern (MID) AF: 0.660 AC: 194 AN: 294

European-Non Finnish (NFE) AF: 0.670 AC: 45548 AN: 67972

Other (OTH) AF: 0.629 AC: 1326 AN: 2108

Alfa AF: 0.645 Hom.: 58533

Bravo AF: 0.595

Asia WGS AF: 0.492 AC: 1712 AN: 3478

ClinVar

Not reported in ClinVar

Computational scores

Source: dbNSFP v4.9

Name	Calibrated prediction	Score	Prediction
BayesDel_noAF	Benign	-0.92
CADD	Benign	0.0030
DANN	Benign	0.31
PhyloP100		-3.6
Mutation Taster		=100/0	polymorphism (auto)

Splicing

Name	Calibrated prediction	Score	Prediction
SpliceAI score (max)		0.0		Details are displayed if max score is > 0.2

Find out detailed SpliceAI scores and Pangolin per-transcript scores at spliceailookup.broadinstitute.org

MaxEntScan Visualizer can be used to analyze the impact of this mutation on the neighboring sequence.

Other links and lift over

dbSNP: rs2241155;

hg19: chr2-206615066;