chr17-41515589-T-C

Position:

• chr17-41515589-T-C

Variant summary

Our verdict is Uncertain significance. Variant got 2 ACMG points: 2P and 0B. PM2

The ENST00000254043.8(KRT15):​c.1130A>G​(p.Glu377Gly) variant causes a missense change involving the alteration of a non-conserved nucleotide. The variant was absent in control chromosomes in GnomAD project. Variant has been reported in ClinVar as Uncertain significance (★).

• Frequency: Genomes: not found (cov: 32)
• Consequence: KRT15 ENST00000254043.8 missense
• Clinical Significance: Uncertain significance criteria provided, single submitter U:1
• Conservation: PhyloP100: 2.23

Genes affected

KRT15 (HGNC:6421): (keratin 15) The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region on chromosome 17q21.2. [provided by RefSeq, Jul 2008]

ACMG classification

Verdict is Uncertain_significance. Variant got 2 ACMG points.

• PM2: Very rare variant in population databases, with high coverage

Transcripts

RefSeq

Gene	Transcript	HGVSc	HGVSp	Effect	#exon/exons	MANE	Protein	UniProt
KRT15	NM_002275.4	c.1130A>G	p.Glu377Gly	missense_variant	6/8	ENST00000254043.8	NP_002266.3
KRT15	XM_011524784.4	c.1151A>G	p.Glu384Gly	missense_variant	6/8		XP_011523086.1
KRT15	XM_017024614.3	c.1151A>G	p.Glu384Gly	missense_variant	6/8		XP_016880103.1

Ensembl

Gene	Transcript	HGVSc	HGVSp	Effect	#exon/exons	TSL	MANE	Protein	Appris	UniProt
KRT15	ENST00000254043.8	c.1130A>G	p.Glu377Gly	missense_variant	6/8	1	NM_002275.4	ENSP00000254043	P1

Frequencies

GnomAD3 genomes Cov.: 32

GnomAD4 exome Cov.: 32

GnomAD4 genome Cov.: 32

ClinVar

Significance: Uncertain significance

Submissions summary: Uncertain:1

Revision: criteria provided, single submitter

Submissions by phenotype

not specified Uncertain:1

Uncertain significance, criteria provided, single submitter

clinical testing

Ambry Genetics

Oct 03, 2022

The c.1130A>G (p.E377G) alteration is located in exon 6 (coding exon 6) of the KRT15 gene. This alteration results from a A to G substitution at nucleotide position 1130, causing the glutamic acid (E) at amino acid position 377 to be replaced by a glycine (G). Based on insufficient or conflicting evidence, the clinical significance of this alteration remains unclear. -

Computational scores

Source: dbNSFP v4.3

Name	Calibrated prediction	Score	Prediction
AlphaMissense	Benign	0.16
BayesDel_addAF	Uncertain	0.10	D
BayesDel_noAF	Benign	-0.090
CADD	Uncertain	24
DANN	Uncertain	1.0
DEOGEN2	Uncertain	0.48	T;D;T;.
Eigen	Benign	0.090
Eigen_PC	Benign	-0.0016
FATHMM_MKL	Benign	0.72	D
LIST_S2	Benign	0.83	.;T;T;T
M_CAP	Uncertain	0.13	D
MetaRNN	Uncertain	0.53	D;D;D;D
MetaSVM	Uncertain	0.57	D
MutationAssessor	Benign	1.8	L;.;L;.
MutationTaster	Benign	1.0	D;D;D;D
PrimateAI	Benign	0.34	T
PROVEAN	Pathogenic	-4.9	D;D;D;D
REVEL	Uncertain	0.55
Sift	Uncertain	0.0020	D;D;D;D
Sift4G	Uncertain	0.0060	D;D;D;.
Polyphen		0.86	P;P;P;.
Vest4		0.40
MutPred		0.48		Loss of disorder (P = 0.0757);.;Loss of disorder (P = 0.0757);.;
MVP		0.89
MPC		0.54
ClinPred		0.96	D
GERP RS		4.7
Varity_R		0.44
gMVP		0.52

Splicing

Name	Calibrated prediction	Score	Prediction
SpliceAI score (max)		0.0		Details are displayed if max score is > 0.2

Find out detailed SpliceAI scores and Pangolin per-transcript scores at spliceailookup.broadinstitute.org

Publications

No publications associated with this variant yet.

Other links and lift over

hg19: chr17-39671841;