GeneBe API: Annotating Genetic Variants Made Easy

This page briefly describes the GeneBe API, which can be utilized for various purposes:

We encourage you to review the brief description below, which outlines the main endpoints.


GeneBe provides a user-friendly API for genetic variant annotation. You can use one of two key endpoints: a GET query for single variant annotation and a POST query for batch annotation. We'll explore the details of this API, its advantages, and how to use it effectively.

Endpoints for Genetic Variant Annotation

GET Endpoint for Single Variant (/api-public/v1/variant)

Ideal for individual variant annotation.
Example Usage without Logging In:
curl -X 'GET' \
'' \
-H 'Accept: application/json'

You can easily see the results in browser:
Example Usage with an API key:
'' \
-H 'Accept: application/json'

POST Endpoint for Batch Annotation (/api-public/v1/variants)

If you need to annotate multiple variants it is recommended to use POST endpoint. It works with multiple variants in batches (up to 1000).
Example Usage Without Logging In:
curl -X 'POST' \
'' \
-H 'Accept: application/json' \
-H 'Content-Type: application/json' \
-d '[{"chr":"22", "pos":28695868, "ref":"AG", "alt":"A"}]'

Example Usage with an API key:
'' \
-H 'Accept: application/json' \
-H 'Content-Type: application/json' \
-d '[{"chr":"22", "pos":28695868, "ref":"AG", "alt":"A"}]'

GeneBe Python client

There is an experimental python API client, available on PyPI. Client can be used as a library for variant annotation as well as a standalone commandline program for VCF and JSON files annotation. Find out documentation on and check usage examples here
Install it with ease by running:
pip install genebe

And then, in your Python script, run the following to obtain annotated variants in a Pandas DataFrame::
import genebe as gnb
input_variants = ['7-69599651-A-G']
df = gnb.annotate_variants_list_to_dataframe(input_variants, flatten_consequences=True)

Find out more in the documentation at .

API Limits and Registration

GeneBe enforces daily query limits per IP address. To access more queries, it's recommended to:
  1. Register an account on GeneBe.
  2. Create an API key on your profile page.
  3. Use Basic Authorization with your email as the username and the API key as the password in your API requests.

You can always see the number of requests you've made by checking header Gb-Requests in API response. For example
Requests 3 for ip#
means that you are unlogged (not using an API key, so requests counts per IP, not per user), and you've made 3 requests already.
Other way to check your Account plan and number of requests you have made is to check the whoami endpoint:
curl -X 'GET' \
  '' \
  -H 'accept: */*'

Or just visit
If you require annotation for hundreds of thousands of variants daily, please contact us.

Detailed Open API documentation

For more comprehensive information, you can refer to the automatically generated GeneBe Rest API documentation .