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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 16-67375277-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=16&pos=67375277&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "16",
"pos": 67375277,
"ref": "G",
"alt": "T",
"effect": "missense_variant",
"transcript": "ENST00000329956.11",
"consequences": [
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC36",
"gene_hgnc_id": 25615,
"hgvs_c": "c.1525G>T",
"hgvs_p": "p.Gly509Cys",
"transcript": "NM_018296.6",
"protein_id": "NP_060766.5",
"transcript_support_level": null,
"aa_start": 509,
"aa_end": null,
"aa_length": 754,
"cds_start": 1525,
"cds_end": null,
"cds_length": 2265,
"cdna_start": 1573,
"cdna_end": null,
"cdna_length": 2428,
"mane_select": "ENST00000329956.11",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC36",
"gene_hgnc_id": 25615,
"hgvs_c": "c.1525G>T",
"hgvs_p": "p.Gly509Cys",
"transcript": "ENST00000329956.11",
"protein_id": "ENSP00000329943.6",
"transcript_support_level": 1,
"aa_start": 509,
"aa_end": null,
"aa_length": 754,
"cds_start": 1525,
"cds_end": null,
"cds_length": 2265,
"cdna_start": 1573,
"cdna_end": null,
"cdna_length": 2428,
"mane_select": "NM_018296.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC36",
"gene_hgnc_id": 25615,
"hgvs_c": "c.1162G>T",
"hgvs_p": "p.Gly388Cys",
"transcript": "ENST00000563189.5",
"protein_id": "ENSP00000455103.1",
"transcript_support_level": 1,
"aa_start": 388,
"aa_end": null,
"aa_length": 633,
"cds_start": 1162,
"cds_end": null,
"cds_length": 1902,
"cdna_start": 1253,
"cdna_end": null,
"cdna_length": 2104,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "LRRC36",
"gene_hgnc_id": 25615,
"hgvs_c": "n.*246-38G>T",
"hgvs_p": null,
"transcript": "ENST00000565019.6",
"protein_id": "ENSP00000464675.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1888,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC36",
"gene_hgnc_id": 25615,
"hgvs_c": "c.1162G>T",
"hgvs_p": "p.Gly388Cys",
"transcript": "NM_001161575.2",
"protein_id": "NP_001155047.1",
"transcript_support_level": null,
"aa_start": 388,
"aa_end": null,
"aa_length": 633,
"cds_start": 1162,
"cds_end": null,
"cds_length": 1902,
"cdna_start": 1266,
"cdna_end": null,
"cdna_length": 2121,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC36",
"gene_hgnc_id": 25615,
"hgvs_c": "c.1525G>T",
"hgvs_p": "p.Gly509Cys",
"transcript": "XM_017023400.3",
"protein_id": "XP_016878889.1",
"transcript_support_level": null,
"aa_start": 509,
"aa_end": null,
"aa_length": 665,
"cds_start": 1525,
"cds_end": null,
"cds_length": 1998,
"cdna_start": 1573,
"cdna_end": null,
"cdna_length": 2170,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC36",
"gene_hgnc_id": 25615,
"hgvs_c": "c.1525G>T",
"hgvs_p": "p.Gly509Cys",
"transcript": "XM_005256025.3",
"protein_id": "XP_005256082.1",
"transcript_support_level": null,
"aa_start": 509,
"aa_end": null,
"aa_length": 647,
"cds_start": 1525,
"cds_end": null,
"cds_length": 1944,
"cdna_start": 1573,
"cdna_end": null,
"cdna_length": 2313,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC36",
"gene_hgnc_id": 25615,
"hgvs_c": "c.1084G>T",
"hgvs_p": "p.Gly362Cys",
"transcript": "XM_005256026.3",
"protein_id": "XP_005256083.1",
"transcript_support_level": null,
"aa_start": 362,
"aa_end": null,
"aa_length": 607,
"cds_start": 1084,
"cds_end": null,
"cds_length": 1824,
"cdna_start": 1132,
"cdna_end": null,
"cdna_length": 1987,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC36",
"gene_hgnc_id": 25615,
"hgvs_c": "c.1525G>T",
"hgvs_p": "p.Gly509Cys",
"transcript": "XM_005256027.3",
"protein_id": "XP_005256084.1",
"transcript_support_level": null,
"aa_start": 509,
"aa_end": null,
"aa_length": 594,
"cds_start": 1525,
"cds_end": null,
"cds_length": 1785,
"cdna_start": 1573,
"cdna_end": null,
"cdna_length": 2167,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC36",
"gene_hgnc_id": 25615,
"hgvs_c": "c.1525G>T",
"hgvs_p": "p.Gly509Cys",
"transcript": "XM_011523200.2",
"protein_id": "XP_011521502.1",
"transcript_support_level": null,
"aa_start": 509,
"aa_end": null,
"aa_length": 594,
"cds_start": 1525,
"cds_end": null,
"cds_length": 1785,
"cdna_start": 1573,
"cdna_end": null,
"cdna_length": 1914,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC36",
"gene_hgnc_id": 25615,
"hgvs_c": "c.1525G>T",
"hgvs_p": "p.Gly509Cys",
"transcript": "XM_047434329.1",
"protein_id": "XP_047290285.1",
"transcript_support_level": null,
"aa_start": 509,
"aa_end": null,
"aa_length": 594,
"cds_start": 1525,
"cds_end": null,
"cds_length": 1785,
"cdna_start": 1573,
"cdna_end": null,
"cdna_length": 1947,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC36",
"gene_hgnc_id": 25615,
"hgvs_c": "c.1021G>T",
"hgvs_p": "p.Gly341Cys",
"transcript": "XM_005256028.2",
"protein_id": "XP_005256085.1",
"transcript_support_level": null,
"aa_start": 341,
"aa_end": null,
"aa_length": 586,
"cds_start": 1021,
"cds_end": null,
"cds_length": 1761,
"cdna_start": 1445,
"cdna_end": null,
"cdna_length": 2300,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC36",
"gene_hgnc_id": 25615,
"hgvs_c": "c.1018G>T",
"hgvs_p": "p.Gly340Cys",
"transcript": "XM_011523202.3",
"protein_id": "XP_011521504.1",
"transcript_support_level": null,
"aa_start": 340,
"aa_end": null,
"aa_length": 585,
"cds_start": 1018,
"cds_end": null,
"cds_length": 1758,
"cdna_start": 1066,
"cdna_end": null,
"cdna_length": 1921,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC36",
"gene_hgnc_id": 25615,
"hgvs_c": "c.907G>T",
"hgvs_p": "p.Gly303Cys",
"transcript": "XM_011523203.2",
"protein_id": "XP_011521505.1",
"transcript_support_level": null,
"aa_start": 303,
"aa_end": null,
"aa_length": 548,
"cds_start": 907,
"cds_end": null,
"cds_length": 1647,
"cdna_start": 955,
"cdna_end": null,
"cdna_length": 1810,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC36",
"gene_hgnc_id": 25615,
"hgvs_c": "c.799G>T",
"hgvs_p": "p.Gly267Cys",
"transcript": "XM_024450338.2",
"protein_id": "XP_024306106.1",
"transcript_support_level": null,
"aa_start": 267,
"aa_end": null,
"aa_length": 512,
"cds_start": 799,
"cds_end": null,
"cds_length": 1539,
"cdna_start": 874,
"cdna_end": null,
"cdna_length": 1729,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC36",
"gene_hgnc_id": 25615,
"hgvs_c": "c.799G>T",
"hgvs_p": "p.Gly267Cys",
"transcript": "XM_047434330.1",
"protein_id": "XP_047290286.1",
"transcript_support_level": null,
"aa_start": 267,
"aa_end": null,
"aa_length": 512,
"cds_start": 799,
"cds_end": null,
"cds_length": 1539,
"cdna_start": 992,
"cdna_end": null,
"cdna_length": 1847,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "G",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC36",
"gene_hgnc_id": 25615,
"hgvs_c": "c.799G>T",
"hgvs_p": "p.Gly267Cys",
"transcript": "XM_047434332.1",
"protein_id": "XP_047290288.1",
"transcript_support_level": null,
"aa_start": 267,
"aa_end": null,
"aa_length": 512,
"cds_start": 799,
"cds_end": null,
"cds_length": 1539,
"cdna_start": 1177,
"cdna_end": null,
"cdna_length": 2032,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC36",
"gene_hgnc_id": 25615,
"hgvs_c": "c.774G>T",
"hgvs_p": "p.Thr258Thr",
"transcript": "XM_017023401.2",
"protein_id": "XP_016878890.1",
"transcript_support_level": null,
"aa_start": 258,
"aa_end": null,
"aa_length": 455,
"cds_start": 774,
"cds_end": null,
"cds_length": 1368,
"cdna_start": 822,
"cdna_end": null,
"cdna_length": 1531,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC36",
"gene_hgnc_id": 25615,
"hgvs_c": "c.597G>T",
"hgvs_p": "p.Thr199Thr",
"transcript": "XM_017023402.2",
"protein_id": "XP_016878891.1",
"transcript_support_level": null,
"aa_start": 199,
"aa_end": null,
"aa_length": 396,
"cds_start": 597,
"cds_end": null,
"cds_length": 1191,
"cdna_start": 645,
"cdna_end": null,
"cdna_length": 1354,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC36",
"gene_hgnc_id": 25615,
"hgvs_c": "n.*851G>T",
"hgvs_p": null,
"transcript": "ENST00000567723.5",
"protein_id": "ENSP00000455799.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2028,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC36",
"gene_hgnc_id": 25615,
"hgvs_c": "n.*20G>T",
"hgvs_p": null,
"transcript": "ENST00000567823.5",
"protein_id": "ENSP00000456164.1",
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1148,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC36",
"gene_hgnc_id": 25615,
"hgvs_c": "n.*265G>T",
"hgvs_p": null,
"transcript": "ENST00000568010.5",
"protein_id": "ENSP00000455018.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1387,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRC36",
"gene_hgnc_id": 25615,
"hgvs_c": "n.*851G>T",
"hgvs_p": null,
"transcript": "ENST00000567723.5",
"protein_id": "ENSP00000455799.1",
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}
],
"message": null
}