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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 17-8228329-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=17&pos=8228329&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "17",
"pos": 8228329,
"ref": "G",
"alt": "C",
"effect": "intron_variant",
"transcript": "ENST00000651323.1",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 22,
"intron_rank_end": null,
"gene_symbol": "CTC1",
"gene_hgnc_id": 26169,
"hgvs_c": "c.3515-10C>G",
"hgvs_p": null,
"transcript": "NM_025099.6",
"protein_id": "NP_079375.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1217,
"cds_start": -4,
"cds_end": null,
"cds_length": 3654,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7039,
"mane_select": "ENST00000651323.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 22,
"intron_rank_end": null,
"gene_symbol": "CTC1",
"gene_hgnc_id": 26169,
"hgvs_c": "c.3515-10C>G",
"hgvs_p": null,
"transcript": "ENST00000651323.1",
"protein_id": "ENSP00000498499.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1217,
"cds_start": -4,
"cds_end": null,
"cds_length": 3654,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7039,
"mane_select": "NM_025099.6",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 20,
"intron_rank_end": null,
"gene_symbol": "CTC1",
"gene_hgnc_id": 26169,
"hgvs_c": "c.3284-10C>G",
"hgvs_p": null,
"transcript": "NM_001411067.1",
"protein_id": "NP_001397996.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1140,
"cds_start": -4,
"cds_end": null,
"cds_length": 3423,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6808,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 20,
"intron_rank_end": null,
"gene_symbol": "CTC1",
"gene_hgnc_id": 26169,
"hgvs_c": "c.3284-10C>G",
"hgvs_p": null,
"transcript": "ENST00000581729.2",
"protein_id": "ENSP00000462720.2",
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": 1140,
"cds_start": -4,
"cds_end": null,
"cds_length": 3423,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3779,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 20,
"intron_rank_end": null,
"gene_symbol": "CTC1",
"gene_hgnc_id": 26169,
"hgvs_c": "c.3251-10C>G",
"hgvs_p": null,
"transcript": "ENST00000580299.2",
"protein_id": "ENSP00000462607.2",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 1129,
"cds_start": -4,
"cds_end": null,
"cds_length": 3390,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3766,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "CTC1",
"gene_hgnc_id": 26169,
"hgvs_c": "c.2387-10C>G",
"hgvs_p": null,
"transcript": "ENST00000699849.1",
"protein_id": "ENSP00000514647.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 841,
"cds_start": -4,
"cds_end": null,
"cds_length": 2526,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4555,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 21,
"intron_rank_end": null,
"gene_symbol": "CTC1",
"gene_hgnc_id": 26169,
"hgvs_c": "n.*249-10C>G",
"hgvs_p": null,
"transcript": "ENST00000449476.7",
"protein_id": "ENSP00000396018.2",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4795,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 22,
"intron_rank_end": null,
"gene_symbol": "CTC1",
"gene_hgnc_id": 26169,
"hgvs_c": "n.3504-10C>G",
"hgvs_p": null,
"transcript": "ENST00000581671.2",
"protein_id": null,
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3887,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 22,
"intron_rank_end": null,
"gene_symbol": "CTC1",
"gene_hgnc_id": 26169,
"hgvs_c": "n.*2222-10C>G",
"hgvs_p": null,
"transcript": "ENST00000643543.1",
"protein_id": "ENSP00000494323.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4859,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": 15,
"intron_rank_end": null,
"gene_symbol": "CTC1",
"gene_hgnc_id": 26169,
"hgvs_c": "n.3447-10C>G",
"hgvs_p": null,
"transcript": "ENST00000699850.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 4876,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "CTC1",
"gene_hgnc_id": 26169,
"hgvs_c": "n.4401-10C>G",
"hgvs_p": null,
"transcript": "ENST00000699851.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 23,
"intron_rank": 22,
"intron_rank_end": null,
"gene_symbol": "CTC1",
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"hgvs_c": "n.*2028-10C>G",
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"transcript": "ENST00000699852.1",
"protein_id": "ENSP00000514648.1",
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},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 22,
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"gene_symbol": "CTC1",
"gene_hgnc_id": 26169,
"hgvs_c": "n.*100-10C>G",
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"transcript": "ENST00000699853.1",
"protein_id": "ENSP00000514649.1",
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},
{
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"strand": false,
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],
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"exon_count": 18,
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"gene_symbol": "CTC1",
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"hgvs_c": "n.4074-10C>G",
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"transcript": "ENST00000699854.1",
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},
{
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],
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},
{
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"strand": false,
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],
"exon_rank": null,
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"intron_rank": 21,
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"gene_symbol": "CTC1",
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"hgvs_c": "n.*466-10C>G",
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"transcript": "ENST00000699856.1",
"protein_id": "ENSP00000514650.1",
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},
{
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],
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},
{
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],
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"gene_symbol": "CTC1",
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"hgvs_c": "n.*2799-10C>G",
"hgvs_p": null,
"transcript": "ENST00000699858.1",
"protein_id": "ENSP00000514651.1",
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},
{
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"strand": false,
"consequences": [
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],
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"exon_count": 21,
"intron_rank": 20,
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"gene_symbol": "CTC1",
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"hgvs_c": "n.*251-10C>G",
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"transcript": "ENST00000699859.1",
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],
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],
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},
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],
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"gene_symbol": "CTC1",
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"hgvs_c": "n.3365-10C>G",
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"transcript": "NR_046431.2",
"protein_id": null,
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"feature": null
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 22,
"intron_rank_end": null,
"gene_symbol": "CTC1",
"gene_hgnc_id": 26169,
"hgvs_c": "c.3410-10C>G",
"hgvs_p": null,
"transcript": "XM_011524010.3",
"protein_id": "XP_011522312.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 1182,
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"feature": null
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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}