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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 3-27284881-G-GA (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=3&pos=27284881&ref=G&alt=GA&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "3",
"pos": 27284881,
"ref": "G",
"alt": "GA",
"effect": "frameshift_variant",
"transcript": "NM_152534.6",
"consequences": [
{
"aa_ref": "H",
"aa_alt": "H?",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 36,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEK10",
"gene_hgnc_id": 18592,
"hgvs_c": "c.1869dupT",
"hgvs_p": "p.His624fs",
"transcript": "NM_001394966.1",
"protein_id": "NP_001381895.1",
"transcript_support_level": null,
"aa_start": 623,
"aa_end": null,
"aa_length": 1115,
"cds_start": 1869,
"cds_end": null,
"cds_length": 3348,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000691995.1",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001394966.1"
},
{
"aa_ref": "H",
"aa_alt": "H?",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 36,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEK10",
"gene_hgnc_id": 18592,
"hgvs_c": "c.1869dupT",
"hgvs_p": "p.His624fs",
"transcript": "ENST00000691995.1",
"protein_id": "ENSP00000509472.1",
"transcript_support_level": null,
"aa_start": 623,
"aa_end": null,
"aa_length": 1115,
"cds_start": 1869,
"cds_end": null,
"cds_length": 3348,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001394966.1",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000691995.1"
},
{
"aa_ref": "H",
"aa_alt": "H?",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 38,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEK10",
"gene_hgnc_id": 18592,
"hgvs_c": "c.1869dupT",
"hgvs_p": "p.His624fs",
"transcript": "NM_001394970.1",
"protein_id": "NP_001381899.1",
"transcript_support_level": null,
"aa_start": 623,
"aa_end": null,
"aa_length": 1172,
"cds_start": 1869,
"cds_end": null,
"cds_length": 3519,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001394970.1"
},
{
"aa_ref": "H",
"aa_alt": "H?",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEK10",
"gene_hgnc_id": 18592,
"hgvs_c": "c.1869dupT",
"hgvs_p": "p.His624fs",
"transcript": "NM_152534.6",
"protein_id": "NP_689747.3",
"transcript_support_level": null,
"aa_start": 623,
"aa_end": null,
"aa_length": 1172,
"cds_start": 1869,
"cds_end": null,
"cds_length": 3519,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_152534.6"
},
{
"aa_ref": "H",
"aa_alt": "H?",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEK10",
"gene_hgnc_id": 18592,
"hgvs_c": "c.1869dupT",
"hgvs_p": "p.His624fs",
"transcript": "ENST00000429845.6",
"protein_id": "ENSP00000395849.2",
"transcript_support_level": 5,
"aa_start": 623,
"aa_end": null,
"aa_length": 1172,
"cds_start": 1869,
"cds_end": null,
"cds_length": 3519,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000429845.6"
},
{
"aa_ref": "H",
"aa_alt": "H?",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 37,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEK10",
"gene_hgnc_id": 18592,
"hgvs_c": "c.1869dupT",
"hgvs_p": "p.His624fs",
"transcript": "NM_001394963.1",
"protein_id": "NP_001381892.1",
"transcript_support_level": null,
"aa_start": 623,
"aa_end": null,
"aa_length": 1162,
"cds_start": 1869,
"cds_end": null,
"cds_length": 3489,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001394963.1"
},
{
"aa_ref": "H",
"aa_alt": "H?",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 38,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEK10",
"gene_hgnc_id": 18592,
"hgvs_c": "c.1869dupT",
"hgvs_p": "p.His624fs",
"transcript": "ENST00000936071.1",
"protein_id": "ENSP00000606130.1",
"transcript_support_level": null,
"aa_start": 623,
"aa_end": null,
"aa_length": 1162,
"cds_start": 1869,
"cds_end": null,
"cds_length": 3489,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000936071.1"
},
{
"aa_ref": "H",
"aa_alt": "H?",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 37,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEK10",
"gene_hgnc_id": 18592,
"hgvs_c": "c.1782dupT",
"hgvs_p": "p.His595fs",
"transcript": "NM_001394964.1",
"protein_id": "NP_001381893.1",
"transcript_support_level": null,
"aa_start": 594,
"aa_end": null,
"aa_length": 1143,
"cds_start": 1782,
"cds_end": null,
"cds_length": 3432,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001394964.1"
},
{
"aa_ref": "H",
"aa_alt": "H?",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 37,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEK10",
"gene_hgnc_id": 18592,
"hgvs_c": "c.1869dupT",
"hgvs_p": "p.His624fs",
"transcript": "NM_001394965.1",
"protein_id": "NP_001381894.1",
"transcript_support_level": null,
"aa_start": 623,
"aa_end": null,
"aa_length": 1125,
"cds_start": 1869,
"cds_end": null,
"cds_length": 3378,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001394965.1"
},
{
"aa_ref": "H",
"aa_alt": "H?",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 38,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEK10",
"gene_hgnc_id": 18592,
"hgvs_c": "c.1869dupT",
"hgvs_p": "p.His624fs",
"transcript": "NM_001394971.1",
"protein_id": "NP_001381900.1",
"transcript_support_level": null,
"aa_start": 623,
"aa_end": null,
"aa_length": 1125,
"cds_start": 1869,
"cds_end": null,
"cds_length": 3378,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001394971.1"
},
{
"aa_ref": "H",
"aa_alt": "H?",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 36,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEK10",
"gene_hgnc_id": 18592,
"hgvs_c": "c.1869dupT",
"hgvs_p": "p.His624fs",
"transcript": "ENST00000898306.1",
"protein_id": "ENSP00000568365.1",
"transcript_support_level": null,
"aa_start": 623,
"aa_end": null,
"aa_length": 1115,
"cds_start": 1869,
"cds_end": null,
"cds_length": 3348,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898306.1"
},
{
"aa_ref": "H",
"aa_alt": "H?",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 36,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEK10",
"gene_hgnc_id": 18592,
"hgvs_c": "c.1782dupT",
"hgvs_p": "p.His595fs",
"transcript": "NM_001394967.1",
"protein_id": "NP_001381896.1",
"transcript_support_level": null,
"aa_start": 594,
"aa_end": null,
"aa_length": 1096,
"cds_start": 1782,
"cds_end": null,
"cds_length": 3291,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001394967.1"
},
{
"aa_ref": "H",
"aa_alt": "H?",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 35,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEK10",
"gene_hgnc_id": 18592,
"hgvs_c": "c.1752dupT",
"hgvs_p": "p.His585fs",
"transcript": "NM_001394968.1",
"protein_id": "NP_001381897.1",
"transcript_support_level": null,
"aa_start": 584,
"aa_end": null,
"aa_length": 1076,
"cds_start": 1752,
"cds_end": null,
"cds_length": 3231,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001394968.1"
},
{
"aa_ref": "H",
"aa_alt": "H?",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 36,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEK10",
"gene_hgnc_id": 18592,
"hgvs_c": "c.1731dupT",
"hgvs_p": "p.His578fs",
"transcript": "ENST00000945408.1",
"protein_id": "ENSP00000615467.1",
"transcript_support_level": null,
"aa_start": 577,
"aa_end": null,
"aa_length": 1069,
"cds_start": 1731,
"cds_end": null,
"cds_length": 3210,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000945408.1"
},
{
"aa_ref": "H",
"aa_alt": "H?",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEK10",
"gene_hgnc_id": 18592,
"hgvs_c": "c.1782dupT",
"hgvs_p": "p.His595fs",
"transcript": "NM_001394969.1",
"protein_id": "NP_001381898.1",
"transcript_support_level": null,
"aa_start": 594,
"aa_end": null,
"aa_length": 1019,
"cds_start": 1782,
"cds_end": null,
"cds_length": 3060,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001394969.1"
},
{
"aa_ref": "H",
"aa_alt": "H?",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEK10",
"gene_hgnc_id": 18592,
"hgvs_c": "c.1869dupT",
"hgvs_p": "p.His624fs",
"transcript": "NM_199347.4",
"protein_id": "NP_955379.2",
"transcript_support_level": null,
"aa_start": 623,
"aa_end": null,
"aa_length": 712,
"cds_start": 1869,
"cds_end": null,
"cds_length": 2139,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_199347.4"
},
{
"aa_ref": "H",
"aa_alt": "H?",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEK10",
"gene_hgnc_id": 18592,
"hgvs_c": "c.1869dupT",
"hgvs_p": "p.His624fs",
"transcript": "ENST00000341435.9",
"protein_id": "ENSP00000343847.5",
"transcript_support_level": 2,
"aa_start": 623,
"aa_end": null,
"aa_length": 712,
"cds_start": 1869,
"cds_end": null,
"cds_length": 2139,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000341435.9"
},
{
"aa_ref": "H",
"aa_alt": "H?",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEK10",
"gene_hgnc_id": 18592,
"hgvs_c": "c.327dupT",
"hgvs_p": "p.His110fs",
"transcript": "ENST00000424275.1",
"protein_id": "ENSP00000392344.1",
"transcript_support_level": 3,
"aa_start": 109,
"aa_end": null,
"aa_length": 195,
"cds_start": 327,
"cds_end": null,
"cds_length": 588,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000424275.1"
},
{
"aa_ref": "H",
"aa_alt": "H?",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEK10",
"gene_hgnc_id": 18592,
"hgvs_c": "c.237dupT",
"hgvs_p": "p.His80fs",
"transcript": "ENST00000435584.5",
"protein_id": "ENSP00000412651.1",
"transcript_support_level": 3,
"aa_start": 79,
"aa_end": null,
"aa_length": 165,
"cds_start": 237,
"cds_end": null,
"cds_length": 498,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000435584.5"
},
{
"aa_ref": "H",
"aa_alt": "H?",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 23,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEK10",
"gene_hgnc_id": 18592,
"hgvs_c": "c.1869dupT",
"hgvs_p": "p.His624fs",
"transcript": "XM_017005762.3",
"protein_id": "XP_016861251.1",
"transcript_support_level": null,
"aa_start": 623,
"aa_end": null,
"aa_length": 1172,
"cds_start": 1869,
"cds_end": null,
"cds_length": 3519,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017005762.3"
},
{
"aa_ref": "H",
"aa_alt": "H?",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 22,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEK10",
"gene_hgnc_id": 18592,
"hgvs_c": "c.1869dupT",
"hgvs_p": "p.His624fs",
"transcript": "XM_017005763.2",
"protein_id": "XP_016861252.1",
"transcript_support_level": null,
"aa_start": 623,
"aa_end": null,
"aa_length": 1172,
"cds_start": 1869,
"cds_end": null,
"cds_length": 3519,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017005763.2"
},
{
"aa_ref": "H",
"aa_alt": "H?",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"frameshift_variant"
],
"exon_rank": 21,
"exon_rank_end": null,
"exon_count": 38,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NEK10",
"gene_hgnc_id": 18592,
"hgvs_c": "c.1869dupT",
"hgvs_p": "p.His624fs",
"transcript": "XM_017005764.2",
"protein_id": "XP_016861253.1",
"transcript_support_level": null,
"aa_start": 623,
"aa_end": null,
"aa_length": 1172,
"cds_start": 1869,
"cds_end": null,
"cds_length": 3519,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
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}