PCA3

prostate cancer associated 3, the group of Long non-coding RNAs with non-systematic symbols

Basic information

Region (hg38): 9:76691980-76863307

Links

ENSG00000225937 ∙ NCBI:50652 ∙ OMIM:604845 ∙ HGNC:8637 ∙ ∙ ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the PCA3 gene.

• Inborn genetic diseases (126 variants)
• not provided (34 variants)

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the PCA3 gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense						0
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)			1			1
splice region						0
non coding			117	23	17	157
Total	0	0	118	23	17

Variants in PCA3

This is a list of pathogenic ClinVar variants found in the PCA3 region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
9-76703397-G-A			Benign (May 08, 2018)
9-76703404-G-A		not specified	Uncertain significance (Jun 22, 2021)
9-76703437-G-C		not specified	Uncertain significance (Jan 02, 2024)
9-76703486-C-G			Benign (Feb 25, 2018)
9-76703487-G-A		not specified	Uncertain significance (Feb 17, 2022)
9-76703545-C-T		not specified	Uncertain significance (Jan 09, 2024)
9-76703607-C-G		not specified	Uncertain significance (Mar 24, 2023)
9-76703650-A-C		not specified	Uncertain significance (May 31, 2023)
9-76703665-C-A		not specified	Uncertain significance (Dec 16, 2023)
9-76703673-T-A		not specified	Uncertain significance (Oct 17, 2023)
9-76703705-C-G		not specified	Uncertain significance (May 07, 2024)
9-76703754-G-A		not specified	Uncertain significance (Apr 28, 2022)
9-76703758-C-T		not specified	Uncertain significance (May 07, 2024)
9-76703759-G-A			Likely benign (Mar 01, 2023)
9-76703879-A-G			Benign (Feb 26, 2018)
9-76703926-G-A		not specified	Uncertain significance (Mar 23, 2023)
9-76703939-A-C		not specified	Uncertain significance (Feb 27, 2023)
9-76703950-G-T			Benign (May 08, 2018)
9-76703958-A-C		not specified	Uncertain significance (Aug 02, 2021)
9-76704061-T-C		not specified	Uncertain significance (Jun 07, 2023)
9-76704827-C-A		not specified	Uncertain significance (Jan 16, 2024)
9-76704853-C-T		not specified	Likely benign (Apr 06, 2024)
9-76704864-C-T			Benign (May 08, 2018)
9-76704964-C-T		not specified	Likely benign (Jan 23, 2024)
9-76704994-G-T		not specified	Uncertain significance (May 08, 2024)

GnomAD

Source: gnomAD

dbNSFP

Source: dbNSFP