17-61686115-T-C

Variant names:

• chr17-61686115-T-C
• rs1555573469
• NM_032043.3:c.2626A>G
• BRIP1 p.Ser876Gly

GermlineCancer (beta)

Variant summary

Our verdict is Uncertain significance.

+1 Uncertain · Cold

-7

-6

-1

0

+5

+6

+9

+10

BenignB

Likely BenignLB

UncertainVUS

Likely PathogenicLP

PathogenicP

The variant received 1 classification points (ACGS-UK Somatic Oncogenicity v2025). O3_ModerateB3_Supporting

The NM_032043.3(BRIP1):c.2626A>G (p.Ser876Gly) variant causes a missense change involving the alteration of a non-conserved nucleotide. The gene BRIP1 is a tumor suppressor gene (CancerMine: 11 TSG, 4 oncogene, 1 driver citations). The gene BRIP1 is a known oncogene (CancerMine: 11 TSG, 4 oncogene, 1 driver citations). The gene BRIP1 is a cancer driver gene (CancerMine: 11 TSG, 4 oncogene, 1 driver citations). The variant is absent from the gnomAD population database at sites with sufficient sequencing coverage. In-silico predictor (REVEL) classifies this variant as likely benign. Splicing prediction tools (SpliceAI) predict no significant impact on normal splicing. Variant has been reported in ClinVar as Uncertain Significance (★★). Other variants at the same amino acid position have been reported in ClinVar (not pathogenic): p.S876N: Conflicting_classifications_of_pathogenicity (ClinVar VariationId 483140); p.S876R: Uncertain_significance (ClinVar VariationId 421096, 2 stars); p.S876R: Uncertain_significance (ClinVar VariationId 2952700, 1 star); p.S876= (synonymous): Benign/Likely_benign (ClinVar VariationId 1332631, 2 stars)

• Frequency: Genomes: not found (cov: 32)
• Consequence: BRIP1 NM_032043.3 missense
• Clinical Significance: Uncertain significance criteria provided, multiple submitters, no conflicts U:4
• Conservation: PhyloP100: 2.60
• Publications: 1 publications found

Genes affected

BRIP1 (HGNC:20473): (BRCA1 interacting DNA helicase 1) The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations. [provided by RefSeq, Jul 2008]

BRIP1 Gene-Disease associations (from GenCC):

• familial ovarian cancer

  Inheritance: AD Classification: DEFINITIVE Submitted by: ClinGen
• Fanconi anemia

  Inheritance: AR Classification: DEFINITIVE, SUPPORTIVE Submitted by: Orphanet, Illumina
• Fanconi anemia complementation group J

  Inheritance: AR Classification: DEFINITIVE, STRONG Submitted by: G2P, Ambry Genetics, PanelApp Australia, Labcorp Genetics (formerly Invitae), ClinGen
• hereditary breast carcinoma

  Inheritance: AD Classification: STRONG, LIMITED, NO_KNOWN Submitted by: ClinGen, Labcorp Genetics (formerly Invitae), Genomics England PanelApp, Ambry Genetics
• colorectal adenoma

  Inheritance: AD Classification: LIMITED Submitted by: Ambry Genetics

Classification according to ACGS-UK Somatic Oncogenicity v2025

Classification was made for transcript:

Our verdict: Uncertain_significance. The variant received 1 points.

Apply	Criterion Code & Title / Strength	Strength	Rationale / Clinical Context
	O3Absent or very rare in population		Absent or extremely rare in gnomAD (AC ≤ 2) — O3 moderate; GnomAD: AF = absent, AC = 0 — absent/extremely rare (O3 moderate [+2])
	B3Computational evidence does not support deleterious effect		Computational evidence does not support a deleterious effect; Missense variant — primary computational scorer does not support an oncogenic/deleterious effect; supports B3

Variant Effect in Transcripts

Automated classification analysis was done for transcript: NM_032043.3. You can select a different transcript below to see updated classification assignments.

RefSeq Transcripts

Sel.	Gene / Transcript	Tags	HGVSc / HGVSp	Effect	Exon rank	Protein / UniProt
	BRIP1 NM_032043.3	MANE Select	c.2626A>G p.Ser876Gly	missense	Exon 19 of 20	Prot: NP_114432.2 UniProt:

BRIP1 NM_032043.3

MANE Select

HGVSc / HGVSpc.2626A>Gp.Ser876Gly

Exon rankExon 19 of 20

missense

Prot: NP_114432.2UniProt: Q9BX63-1

Ensembl Transcripts

Sel.	Gene / Transcript	Tags	HGVSc / HGVSp	Effect	Exon rank	Protein / UniProt
	BRIP1 ENST00000259008.7	TSL:1MANE Select	c.2626A>G p.Ser876Gly	missense	Exon 19 of 20	Prot: ENSP00000259008.2 UniProt:
	BRIP1 ENST00000682453.1		c.2626A>G p.Ser876Gly	missense	Exon 20 of 21	Prot: ENSP00000506943.1 UniProt:
	BRIP1 ENST00000683039.1		c.2626A>G p.Ser876Gly	missense	Exon 20 of 21	Prot: ENSP00000508303.1 UniProt:

BRIP1 ENST00000259008.7

TSL:1MANE Select

HGVSc / HGVSpc.2626A>Gp.Ser876Gly

Exon rankExon 19 of 20

missense

Prot: ENSP00000259008.2UniProt: Q9BX63-1

BRIP1 ENST00000682453.1

HGVSc / HGVSpc.2626A>Gp.Ser876Gly

Exon rankExon 20 of 21

missense

Prot: ENSP00000506943.1UniProt: Q9BX63-1

BRIP1 ENST00000683039.1

HGVSc / HGVSpc.2626A>Gp.Ser876Gly

Exon rankExon 20 of 21

missense

Prot: ENSP00000508303.1UniProt: Q9BX63-1

Frequencies

Allele frequencies (AF), counts (AC/AN), homozygotes and coverage

Common (AF > 0.05 / Hom > 5)

Rare (AF ≤ 0.0001 / Hom ≤ 1)

Source / population	AF	AC	Hom	AN	Coverage
Global population databases 3 sources Large-scale international reference populations
GnomAD3 genomes	AF:	AC:	Hom:	AN:	Cov:32
GnomAD4 exome	AF:	AC:	Hom:	AN:	Cov:34
GnomAD4 genome	AF:	AC:	Hom:	AN:	Cov:32

Showing 3 sources

Case/control cohorts

Cohort	Cases			Controls
	AF	AC	AN	AF	AC	AN
SCHEMA(Schizophrenia)	0.0000206	1	48458	0.00	0	74562

Showing 1 cohortAllele count / allele number. AF is computed from the counts for ASC (not provided by the source).

ClinVar

ClinVar submissions

Significance: Uncertain significance

Revision: criteria provided, multiple submitters, no conflicts

Pathogenic	VUS	Benign	Condition
-	2	-	not provided (2)
-	1	-	Familial cancer of breast;C1836860:Fanconi anemia complementation group J (1)
-	1	-	Hereditary cancer-predisposing syndrome (1)

Computational Scores

Algorithm	Calibrated pred.	Score	Prediction
AlphaGenome AVI	Uncertain	19
AlphaMissense	Benign	0.064
BayesDel_addAF	Benign	0.0063	T
BayesDel_noAF	Benign	-0.23
CADD	Benign	21
DANN	Uncertain	0.99
DEOGEN2	Benign	0.14	T
Eigen	Benign	0.18
Eigen_PC	Uncertain	0.31
FATHMM_MKL	Uncertain	0.86	D
FuncVEP CTI	Benign	0.080
GPN-Star LLR	N/A	-4.4
GPN-Star score	N/A	4.4
LIST_S2	Benign	0.73	T
M_CAP	Benign	0.047	D
MetaRNN	Benign	0.23	T
MetaSVM	Benign	-0.29	T
MutationAssessor	Uncertain	2.1	M
PhyloP100	Benign	2.6
popEVE	Benign	-3.5
PrimateAI	Benign	0.43	T
PROVEAN	Benign	-1.6	N
REVEL	Benign	0.23
Sift	Benign	0.30	T
Sift4G	Benign	0.42	T
Varity_R	N/A	0.21
VESM-3B	Benign	-5.4

Showing 27 of 27 scores

Splicing Scores

Algorithm	Calibrated pred.	Score	Prediction
Pangolin (max)	Benign	0.050
SpliceAI score (max)	Benign	0.060	Details are displayed if max score is > 0.2

Showing 2 of 2 scores

Find out detailed SpliceAI scores and Pangolin per-transcript scores at spliceailookup.broadinstitute.org

MaxEntScan Visualizer can be used to analyze the impact of this mutation on the neighboring sequence.

MaveDB functional evidence

MaveDB is a public repository of laboratory assays that test the effect of thousands of variants at once — treat this as supporting research data and interpret it with great caution; it is not a clinical classification.

No MaveDB functional evidence found for this variant.

Other links and lift over

dbSNP: rs1555573469;

hg19: chr17-59763476;

ACMG debug oncogenicity

ACGS debug oncogenicity

ACMG debug germline

Submit to ClinVar