17-63929073-G-C

Variant summary

Our verdict is Benign. Variant got -14 ACMG points: 0P and 14B. BP4_Strong BP6_Moderate BA1

The NM_000626.4(CD79B):c.*153C>G variant causes a 3 prime UTR change involving the alteration of a non-conserved nucleotide. The variant allele was found at a frequency of 0.365 in 674,212 control chromosomes in the GnomAD database, including 47,434 homozygotes. In-silico tool predicts a benign outcome for this variant. Variant has been reported in ClinVar as Benign (★).

• Frequency:
  • Genomes: 𝑓 0.32 (8692 hom., cov: 33)
  • Exomes 𝑓: 0.38 (38742 hom.)
• Consequence: CD79B NM_000626.4 3_prime_UTR
• Clinical Significance: Benign criteria provided, single submitter B:1
• Conservation: PhyloP100: 1.17

Genes affected

CD79B (HGNC:1699): (CD79b molecule) The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

ACMG classification

Verdict is Benign. Variant got -14 ACMG points.

• BP4: Computational evidence support a benign effect (BayesDel_noAF=-0.82).
• BP6: Variant 17-63929073-G-C is Benign according to our data. Variant chr17-63929073-G-C is described in ClinVar as [Benign]. Clinvar id is 1272184.Status of the report is criteria_provided_single_submitter, 1 stars.
• BA1: GnomAd4 highest subpopulation (EAS) allele frequency at 95% confidence interval = 0.397 is higher than 0.05.

Transcripts

RefSeq

Gene	Transcript	HGVSc	HGVSp	Effect	#exon/exons	MANE	UniProt
CD79B	NM_000626.4	c.*153C>G		3_prime_UTR_variant	6/6	ENST00000006750.8
CD79B	NM_001039933.3	c.*153C>G		3_prime_UTR_variant	6/6
CD79B	NM_001329050.2	c.*153C>G		3_prime_UTR_variant	5/5
CD79B	NM_021602.4	c.*153C>G		3_prime_UTR_variant	5/5

Ensembl

Gene	Transcript	HGVSc	HGVSp	Effect	#exon/exons	TSL	MANE	Appris	UniProt
CD79B	ENST00000006750.8	c.*153C>G		3_prime_UTR_variant	6/6	1	NM_000626.4	P4
CD79B	ENST00000392795.7	c.*153C>G		3_prime_UTR_variant	6/6	1		A1
CD79B	ENST00000559358.1	n.854C>G		non_coding_transcript_exon_variant	4/4	2
CD79B	ENST00000698624.1	n.840C>G		non_coding_transcript_exon_variant	5/5

Frequencies

GnomAD3 genomes AF: 0.318 AC: 48275 AN: 151916 Hom.: 8685 Cov.: 33

Gnomad AFR AF: 0.137

Gnomad AMI AF: 0.471

Gnomad AMR AF: 0.334

Gnomad ASJ AF: 0.428

Gnomad EAS AF: 0.404

Gnomad SAS AF: 0.278

Gnomad FIN AF: 0.381

Gnomad MID AF: 0.434

Gnomad NFE AF: 0.401

Gnomad OTH AF: 0.353

GnomAD4 exome AF: 0.379 AC: 197975 AN: 522178 Hom.: 38742 Cov.: 5 AF XY: 0.376 AC XY: 105284 AN XY: 280048

Gnomad4 AFR exome AF: 0.136

Gnomad4 AMR exome AF: 0.349

Gnomad4 ASJ exome AF: 0.441

Gnomad4 EAS exome AF: 0.415

Gnomad4 SAS exome AF: 0.293

Gnomad4 FIN exome AF: 0.370

Gnomad4 NFE exome AF: 0.403

Gnomad4 OTH exome AF: 0.386

GnomAD4 genome AF: 0.318 AC: 48307 AN: 152034 Hom.: 8692 Cov.: 33 AF XY: 0.316 AC XY: 23456 AN XY: 74296

Gnomad4 AFR AF: 0.137

Gnomad4 AMR AF: 0.334

Gnomad4 ASJ AF: 0.428

Gnomad4 EAS AF: 0.403

Gnomad4 SAS AF: 0.279

Gnomad4 FIN AF: 0.381

Gnomad4 NFE AF: 0.401

Gnomad4 OTH AF: 0.356

Alfa AF: 0.255 Hom.: 718

Bravo AF: 0.311

ClinVar

Significance: Benign

Submissions summary: Benign:1

Revision: criteria provided, single submitter

Submissions by phenotype

not provided Benign:1

Benign, criteria provided, single submitter

clinical testing

GeneDx

Nov 10, 2018

- -

Computational scores

Source: dbNSFP v4.3

Name	Calibrated prediction	Score	Prediction
BayesDel_noAF	Benign	-0.82
Cadd	Benign	12
Dann	Benign	0.67

Splicing

Name	Calibrated prediction	Score	Prediction
SpliceAI score (max)		0.050		Details are displayed if max score is > 0.2

Find out detailed SpliceAI scores and Pangolin per-transcript scores at spliceailookup.broadinstitute.org

Publications

LitVar

Other links and lift over

dbSNP: rs1051688; hg19: chr17-62006433; COSMIC: COSV50084781; COSMIC: COSV50084781;