NM_001366386.2:c.449-518T>C

Variant names:

• chr2-201822291-T-C
• rs7585095
• NM_001366386.2:c.449-518T>C

Variant summary

Our verdict is Benign. The variant received -12 ACMG points: 0P and 12B. BP4_Strong BA1

The NM_001366386.2(CDK15):​c.449-518T>C variant causes a intron change involving the alteration of a non-conserved nucleotide. The variant allele was found at a frequency of 0.909 in 152,240 control chromosomes in the GnomAD database, including 63,421 homozygotes. In-silico tool predicts a benign outcome for this variant. No clinical diagnostic laboratories have submitted clinical-significance assessments for this variant to ClinVar.

• Frequency: Genomes: 𝑓 0.91 (63421 hom., cov: 32)
• Consequence: CDK15 NM_001366386.2 intron
• Clinical Significance: Not reported in ClinVar
• Conservation: PhyloP100: -0.261
• Publications: 2 publications found

Genes affected

CDK15 (HGNC:14434): (cyclin dependent kinase 15) Enables protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation and regulation of transcription involved in G1/S transition of mitotic cell cycle. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ACMG classification

Our verdict: Benign. The variant received -12 ACMG points.

• BP4: Computational evidence support a benign effect (BayesDel_noAF=-0.9).
• BA1: GnomAd4 highest subpopulation (EAS) allele frequency at 95% confidence interval = 0.977 is higher than 0.05.

Variant Effect in Transcripts

ACMG analysis was done for transcript: NM_001366386.2. You can select a different transcript below to see updated ACMG assignments.

RefSeq Transcripts

Selected	Gene	Transcript	Tags	HGVSc	HGVSp	Effect	Exon Rank	Protein	UniProt
	CDK15	NM_001366386.2	MANE Select	c.449-518T>C		intron	N/A	NP_001353315.1
	CDK15	NM_001261435.1		c.449-518T>C		intron	N/A	NP_001248364.1
	CDK15	NM_001261436.1		c.449-518T>C		intron	N/A	NP_001248365.1

Ensembl Transcripts

Selected	Gene	Transcript	Tags	HGVSc	HGVSp	Effect	Exon Rank	Protein	UniProt
	CDK15	ENST00000652192.3	MANE Select	c.449-518T>C		intron	N/A	ENSP00000498608.2
	CDK15	ENST00000450471.6	TSL:1	c.449-518T>C		intron	N/A	ENSP00000406472.2
	CDK15	ENST00000434439.1	TSL:1	c.449-518T>C		intron	N/A	ENSP00000412775.1

Frequencies

GnomAD3 genomes AF: 0.909 AC: 138250 AN: 152122 Hom.: 63390 Cov.: 32

Gnomad AFR AF: 0.770

Gnomad AMI AF: 0.979

Gnomad AMR AF: 0.957

Gnomad ASJ AF: 0.972

Gnomad EAS AF: 1.00

Gnomad SAS AF: 0.966

Gnomad FIN AF: 0.954

Gnomad MID AF: 0.940

Gnomad NFE AF: 0.960

Gnomad OTH AF: 0.920

We have no GnomAD4 exomes data on this position. Probably position not covered by the project.

GnomAD4 genome AF: 0.909 AC: 138334 AN: 152240 Hom.: 63421 Cov.: 32 AF XY: 0.910 AC XY: 67750 AN XY: 74432

African (AFR) AF: 0.770 AC: 31949 AN: 41496

American (AMR) AF: 0.957 AC: 14644 AN: 15308

Ashkenazi Jewish (ASJ) AF: 0.972 AC: 3376 AN: 3472

East Asian (EAS) AF: 1.00 AC: 5177 AN: 5178

South Asian (SAS) AF: 0.966 AC: 4666 AN: 4830

European-Finnish (FIN) AF: 0.954 AC: 10112 AN: 10600

Middle Eastern (MID) AF: 0.942 AC: 277 AN: 294

European-Non Finnish (NFE) AF: 0.960 AC: 65292 AN: 68034

Other (OTH) AF: 0.921 AC: 1948 AN: 2116

Alfa AF: 0.948 Hom.: 110049

Bravo AF: 0.904

Asia WGS AF: 0.969 AC: 3368 AN: 3478

ClinVar

Not reported in ClinVar

Computational scores

Source: dbNSFP v4.9

Name	Calibrated prediction	Score	Prediction
BayesDel_noAF	Benign	-0.90
CADD	Benign	3.0
DANN	Benign	0.50
PhyloP100		-0.26
Mutation Taster		=100/0	polymorphism (auto)

Splicing

Name	Calibrated prediction	Score	Prediction
SpliceAI score (max)		0.0		Details are displayed if max score is > 0.2

Find out detailed SpliceAI scores and Pangolin per-transcript scores at spliceailookup.broadinstitute.org

Other links and lift over

dbSNP: rs7585095; hg19: chr2-202687014;