NM_007294.4:c.1374C>A

Variant names:

• chr17-43094157-G-T
• rs879253999
• NM_007294.4:c.1374C>A

Variant summary

Our verdict is Uncertain significance. The variant received 3 ACMG points: 4P and 1B. PM2 PP3_Moderate BP6

The NM_007294.4(BRCA1):​c.1374C>A​(p.Asp458Glu) variant causes a missense change involving the alteration of a non-conserved nucleotide. The variant allele was found at a frequency of 0.000000684 in 1,461,714 control chromosomes in the GnomAD database, with no homozygous occurrence. In-silico tool predicts a pathogenic outcome for this variant. Variant has been reported in ClinVar as Conflicting classifications of pathogenicity (no stars). Another nucleotide change resulting in the same amino acid substitution has been previously reported as Likely benign in ClinVar. Another variant affecting the same amino acid position, but resulting in a different missense (i.e. D458V) has been classified as Likely benign.

• Frequency:
  • Genomes: not found (cov: 32)
  • Exomes 𝑓: 6.8e-7 (0 hom.)
• Consequence: BRCA1 NM_007294.4 missense
• Clinical Significance: Conflicting classifications of pathogenicity criteria provided, conflicting classifications U:2 B:1
• Conservation: PhyloP100: 0.659
• Publications: 7 publications found

Genes affected

BRCA1 (HGNC:1100): (BRCA1 DNA repair associated) This gene encodes a 190 kD nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The BRCA1 gene contains 22 exons spanning about 110 kb of DNA. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2020]

BRCA1 Gene-Disease associations (from GenCC):

• breast-ovarian cancer, familial, susceptibility to, 1

  Inheritance: AD Classification: DEFINITIVE, STRONG Submitted by: Ambry Genetics, ClinGen, Labcorp Genetics (formerly Invitae), Genomics England PanelApp
• Fanconi anemia, complementation group S

  Inheritance: AR Classification: DEFINITIVE, STRONG, MODERATE, LIMITED Submitted by: G2P, Labcorp Genetics (formerly Invitae), ClinGen, Ambry Genetics
• pancreatic cancer, susceptibility to, 4

  Inheritance: AD Classification: MODERATE Submitted by: Genomics England PanelApp
• hereditary breast ovarian cancer syndrome

  Inheritance: AD Classification: SUPPORTIVE Submitted by: Orphanet
• Fanconi anemia

  Inheritance: AR Classification: SUPPORTIVE Submitted by: Orphanet

ACMG classification

Our verdict: Uncertain_significance. The variant received 3 ACMG points.

• PM2: Very rare variant in population databases, with high coverage
• PP3: MetaRNN computational evidence supports a deleterious effect, 0.875
• BP6: Variant 17-43094157-G-T is Benign according to our data. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916. Variant chr17-43094157-G-T is described in CliVar as Conflicting_classifications_of_pathogenicity. Clinvar id is 245916.

Transcripts

RefSeq

Gene	Transcript	HGVSc	HGVSp	Effect	Exon rank	MANE	Protein	UniProt
BRCA1	NM_007294.4	c.1374C>A	p.Asp458Glu	missense_variant	Exon 10 of 23	ENST00000357654.9	NP_009225.1

Ensembl

Gene	Transcript	HGVSc	HGVSp	Effect	Exon rank	TSL	MANE	Protein	Appris	UniProt
BRCA1	ENST00000357654.9	c.1374C>A	p.Asp458Glu	missense_variant	Exon 10 of 23	1	NM_007294.4	ENSP00000350283.3

Frequencies

GnomAD3 genomes Cov.: 32

GnomAD4 exome AF: 6.84e-7 AC: 1 AN: 1461714 Hom.: 0 Cov.: 34 AF XY: 0.00000138 AC XY: 1 AN XY: 727160

African (AFR) AF: 0.00 AC: 0 AN: 33458

American (AMR) AF: 0.00 AC: 0 AN: 44708

Ashkenazi Jewish (ASJ) AF: 0.00 AC: 0 AN: 26130

East Asian (EAS) AF: 0.00 AC: 0 AN: 39686

South Asian (SAS) AF: 0.00 AC: 0 AN: 86238

European-Finnish (FIN) AF: 0.00 AC: 0 AN: 53374

Middle Eastern (MID) AF: 0.00 AC: 0 AN: 5768

European-Non Finnish (NFE) AF: 8.99e-7 AC: 1 AN: 1111966

Other (OTH) AF: 0.00 AC: 0 AN: 60386

GnomAD4 genome Cov.: 32

ClinVar

Significance: Conflicting classifications of pathogenicity

Submissions summary: Uncertain:2 Benign:1

Revision: criteria provided, conflicting classifications

Submissions by phenotype

not provided Uncertain:1

Feb 24, 2016

GeneDx

Significance: Uncertain significance

Review Status: criteria provided, single submitter

Collection Method: clinical testing

This variant is denoted BRCA1 c.1374C>A at the cDNA level, p.Asp458Glu (D458E) at the protein level, and results in the change of an Aspartic Acid to a Glutamic Acid (GAC>GAA). Using alternate nomenclature, this variant would be defined as BRCA1 1493C>A. This variant has not, to our knowledge, been published in the literature as pathogenic or benign. BRCA1 Asp458Glu was not observed in approximately 6,500 individuals of European and African American ancestry in the NHLBI Exome Sequencing Project, suggesting it is not a common benign variant in these populations. Since Aspartic Acid and Glutamic Acid share similar properties, this is considered a conservative amino acid substitution. BRCA1 Asp458Glu occurs at a position that is conserved across species and is located in the DNA binding domain as well as a region known to interact with multiple other proteins (Narod 2004). In silico analyses are inconsistent regarding the effect this variant may have on protein structure and function. Based on currently available evidence, it is unclear whether BRCA1 Asp458Glu is a pathogenic or benign variant. We consider it to be a variant of uncertain significance. -

Hereditary breast ovarian cancer syndrome Uncertain:1

Apr 06, 2023

Labcorp Genetics (formerly Invitae), Labcorp

Significance: Uncertain significance

Review Status: criteria provided, single submitter

Collection Method: clinical testing

This sequence change replaces aspartic acid, which is acidic and polar, with glutamic acid, which is acidic and polar, at codon 458 of the BRCA1 protein (p.Asp458Glu). This variant is not present in population databases (gnomAD no frequency). This missense change has been observed in individual(s) with breast and/or ovarian cancer (PMID: 15146556). This variant is also known as c.1493C>G. ClinVar contains an entry for this variant (Variation ID: 245916). Advanced modeling of protein sequence and biophysical properties (such as structural, functional, and spatial information, amino acid conservation, physicochemical variation, residue mobility, and thermodynamic stability) performed at Invitae indicates that this missense variant is not expected to disrupt BRCA1 protein function. In summary, the available evidence is currently insufficient to determine the role of this variant in disease. Therefore, it has been classified as a Variant of Uncertain Significance. -

Hereditary cancer-predisposing syndrome Benign:1

Mar 23, 2023

University of Washington Department of Laboratory Medicine, University of Washington

Significance: Likely benign

Review Status: criteria provided, single submitter

Collection Method: curation

Missense variant in a coldspot region where missense variants are very unlikely to be pathogenic (PMID:31911673). -

Computational scores

Source: dbNSFP v4.3

Name	Calibrated prediction	Score	Prediction
AlphaMissense	Pathogenic	0.72
BayesDel_addAF	Pathogenic	0.34	D
BayesDel_noAF	Pathogenic	0.25
CADD	Benign	18
DANN	Uncertain	0.99
DEOGEN2	Uncertain	0.64	D;.;.;.;T;T;.;.;T
Eigen	Benign	0.045
Eigen_PC	Benign	-0.18
FATHMM_MKL	Benign	0.71	D
LIST_S2	Benign	0.86	D;D;D;D;D;D;D;D;D
M_CAP	Pathogenic	0.51	D
MetaRNN	Pathogenic	0.88	D;D;D;D;D;D;D;D;D
MetaSVM	Uncertain	0.74	D
MutationAssessor	Pathogenic	3.1	M;M;.;.;.;.;.;.;.
PhyloP100		0.66
PrimateAI	Benign	0.45	T
PROVEAN	Uncertain	-4.0	D;D;D;D;.;D;D;D;D
REVEL	Pathogenic	0.69
Sift	Uncertain	0.0070	D;D;D;D;.;D;D;D;D
Sift4G	Benign	0.16	T;T;T;T;.;T;.;D;T
Polyphen		1.0	D;.;.;D;.;.;.;.;.
Vest4		0.68
MutPred		0.67		Gain of helix (P = 0.0078);Gain of helix (P = 0.0078);.;Gain of helix (P = 0.0078);.;Gain of helix (P = 0.0078);.;.;Gain of helix (P = 0.0078);
MVP		0.95
MPC		0.44
ClinPred		0.99	D
GERP RS		-0.56
Varity_R		0.23
gMVP		0.11

Splicing

Name	Calibrated prediction	Score	Prediction
SpliceAI score (max)		0.0		Details are displayed if max score is > 0.2

Find out detailed SpliceAI scores and Pangolin per-transcript scores at spliceailookup.broadinstitute.org

Other links and lift over

dbSNP: rs879253999; hg19: chr17-41246174;