NM_007294.4:c.2413T>C

Variant names:

• chr17-43093118-A-G
• rs397508966
• NM_007294.4:c.2413T>C

Variant summary

Our verdict is Uncertain significance. The variant received 2 ACMG points: 4P and 2B. PM2 PP3_Moderate BP6_Moderate

The NM_007294.4(BRCA1):​c.2413T>C​(p.Cys805Arg) variant causes a missense change involving the alteration of a non-conserved nucleotide. The variant was absent in control chromosomes in GnomAD project. In-silico tool predicts a pathogenic outcome for this variant. Variant has been reported in ClinVar as Likely benign (★). Another variant affecting the same amino acid position, but resulting in a different missense (i.e. C805G) has been classified as Likely benign.

• Frequency: Genomes: not found (cov: 32)
• Consequence: BRCA1 NM_007294.4 missense
• Clinical Significance: Likely benign criteria provided, single submitter B:1 O:1
• Conservation: PhyloP100: 0.488
• Publications: 9 publications found

Genes affected

BRCA1 (HGNC:1100): (BRCA1 DNA repair associated) This gene encodes a 190 kD nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The BRCA1 gene contains 22 exons spanning about 110 kb of DNA. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2020]

BRCA1 Gene-Disease associations (from GenCC):

• breast-ovarian cancer, familial, susceptibility to, 1

  Inheritance: AD Classification: DEFINITIVE, STRONG Submitted by: Ambry Genetics, ClinGen, Labcorp Genetics (formerly Invitae), Genomics England PanelApp
• Fanconi anemia, complementation group S

  Inheritance: AR Classification: DEFINITIVE, STRONG, MODERATE, LIMITED Submitted by: G2P, Labcorp Genetics (formerly Invitae), ClinGen, Ambry Genetics
• pancreatic cancer, susceptibility to, 4

  Inheritance: AD Classification: MODERATE Submitted by: Genomics England PanelApp
• hereditary breast ovarian cancer syndrome

  Inheritance: AD Classification: SUPPORTIVE Submitted by: Orphanet
• Fanconi anemia

  Inheritance: AR Classification: SUPPORTIVE Submitted by: Orphanet

ACMG classification

Our verdict: Uncertain_significance. The variant received 2 ACMG points.

• PM2: Very rare variant in population databases, with high coverage
• PP3: MetaRNN computational evidence supports a deleterious effect, 0.928
• BP6: Variant 17-43093118-A-G is Benign according to our data. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr17-43093118-A-G is described in CliVar as Likely_benign. Clinvar id is 54562.Status of the report is criteria_provided_single_submitter, 1 stars.

Transcripts

RefSeq

Gene	Transcript	HGVSc	HGVSp	Effect	Exon rank	MANE	Protein	UniProt
BRCA1	NM_007294.4	c.2413T>C	p.Cys805Arg	missense_variant	Exon 10 of 23	ENST00000357654.9	NP_009225.1

Ensembl

Gene	Transcript	HGVSc	HGVSp	Effect	Exon rank	TSL	MANE	Protein	Appris	UniProt
BRCA1	ENST00000357654.9	c.2413T>C	p.Cys805Arg	missense_variant	Exon 10 of 23	1	NM_007294.4	ENSP00000350283.3

Frequencies

GnomAD3 genomes Cov.: 32

GnomAD4 exome Cov.: 41

GnomAD4 genome Cov.: 32

Alfa AF: 0.00 Hom.: 0

ClinVar

Significance: Likely benign

Submissions summary: Benign:1 Other:1

Revision: criteria provided, single submitter

Submissions by phenotype

Hereditary cancer-predisposing syndrome Benign:1

Mar 23, 2023

University of Washington Department of Laboratory Medicine, University of Washington

Significance: Likely benign

Review Status: criteria provided, single submitter

Collection Method: curation

Missense variant in a coldspot region where missense variants are very unlikely to be pathogenic (PMID:31911673). -

Familial cancer of breast Other:1

-

ClinVar Staff, National Center for Biotechnology Information (NCBI)

Significance: not provided

Review Status: no classification provided

Collection Method: literature only

- -

Computational scores

Source: dbNSFP v4.3

Name	Calibrated prediction	Score	Prediction
AlphaMissense	Benign	0.16
BayesDel_addAF	Pathogenic	0.18	D
BayesDel_noAF	Uncertain	0.020
CADD	Benign	10
DANN	Benign	0.59
DEOGEN2	Uncertain	0.56	D;.;.;.;T
Eigen	Benign	-0.80
Eigen_PC	Benign	-0.97
FATHMM_MKL	Benign	0.085	N
LIST_S2	Benign	0.59	T;T;T;T;T
M_CAP	Benign	0.084	D
MetaRNN	Pathogenic	0.93	D;D;D;D;D
MetaSVM	Benign	-0.58	T
MutationAssessor	Uncertain	2.5	M;M;.;.;.
PhyloP100		0.49
PrimateAI	Benign	0.34	T
PROVEAN	Pathogenic	-6.9	D;D;D;D;.
REVEL	Uncertain	0.43
Sift	Benign	0.081	T;T;T;T;.
Sift4G	Benign	0.081	T;T;T;T;.
Polyphen		0.11	B;.;.;D;.
Vest4		0.52
MutPred		0.85		Gain of disorder (P = 0.0359);Gain of disorder (P = 0.0359);.;Gain of disorder (P = 0.0359);.;
MVP		0.39
MPC		0.16
ClinPred		0.44	T
GERP RS		-1.6
Varity_R		0.17
gMVP		0.17
Mutation Taster		=2/98	disease causing

Splicing

Name	Calibrated prediction	Score	Prediction
SpliceAI score (max)		0.0		Details are displayed if max score is > 0.2

Find out detailed SpliceAI scores and Pangolin per-transcript scores at spliceailookup.broadinstitute.org

Other links and lift over

dbSNP: rs397508966; hg19: chr17-41245135;