NM_025098.4:c.25A>G

Variant names:

• chr11-75717913-A-G
• rs554202
• NM_025098.4:c.25A>G

Variant summary

Our verdict is Benign. The variant received -12 ACMG points: 0P and 12B. BP4_Strong BA1

The NM_025098.4(MOGAT2):​c.25A>G​(p.Met9Val) variant causes a missense change involving the alteration of a non-conserved nucleotide. The variant allele was found at a frequency of 0.437 in 1,613,620 control chromosomes in the GnomAD database, including 158,059 homozygotes. In-silico tool predicts a benign outcome for this variant. 14/21 in silico tools predict a benign outcome for this variant. No clinical diagnostic laboratories have submitted clinical-significance assessments for this variant to ClinVar.

• Frequency:
  • Genomes: 𝑓 0.42 (13971 hom., cov: 33)
  • Exomes 𝑓: 0.44 (144088 hom.)
• Consequence: MOGAT2 NM_025098.4 missense
• Clinical Significance: Not reported in ClinVar
• Conservation: PhyloP100: -0.169
• Publications: 35 publications found

Genes affected

MOGAT2 (HGNC:23248): (monoacylglycerol O-acyltransferase 2) The protein encoded by this gene is an enzyme that catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. The encoded protein is important in the uptake of dietary fat by the small intestine. This protein forms a complex with diacylglycerol O-acyltransferase 2 in the endoplasmic reticulum, and this complex catalyzes the synthesis of triacylglycerol. [provided by RefSeq, Dec 2015]

ENSG00000300258 (HGNC:):

ACMG classification

Our verdict: Benign. The variant received -12 ACMG points.

• BP4: Computational evidence support a benign effect (MetaRNN=0.0016142428).
• BA1: GnomAd4 highest subpopulation (NFE) allele frequency at 95% confidence interval = 0.46 is higher than 0.05.

Variant Effect in Transcripts

ACMG analysis was done for transcript: NM_025098.4. You can select a different transcript below to see updated ACMG assignments.

RefSeq Transcripts

Sel.	Gene	Transcript	Tags	HGVSc	HGVSp	Effect	Exon Rank	Protein	UniProt
	MOGAT2	NM_025098.4	MANE Select	c.25A>G	p.Met9Val	missense	Exon 1 of 6	NP_079374.2

Ensembl Transcripts

Sel.	Gene	Transcript	Tags	HGVSc	HGVSp	Effect	Exon Rank	Protein	UniProt
	MOGAT2	ENST00000198801.10	TSL:1 MANE Select	c.25A>G	p.Met9Val	missense	Exon 1 of 6	ENSP00000198801.5	Q3SYC2-1
	MOGAT2	ENST00000888392.1		c.25A>G	p.Met9Val	missense	Exon 1 of 7	ENSP00000558451.1
	MOGAT2	ENST00000965478.1		c.25A>G	p.Met9Val	missense	Exon 1 of 6	ENSP00000635537.1

Frequencies

GnomAD3 genomes AF: 0.423 AC: 64277 AN: 151992 Hom.: 13957 Cov.: 33

Gnomad AFR AF: 0.430

Gnomad AMI AF: 0.272

Gnomad AMR AF: 0.352

Gnomad ASJ AF: 0.450

Gnomad EAS AF: 0.162

Gnomad SAS AF: 0.373

Gnomad FIN AF: 0.382

Gnomad MID AF: 0.455

Gnomad NFE AF: 0.464

Gnomad OTH AF: 0.447

GnomAD2 exomes AF: 0.390 AC: 98004 AN: 250972 AF XY: 0.397

Gnomad AFR exome AF: 0.427

Gnomad AMR exome AF: 0.246

Gnomad ASJ exome AF: 0.447

Gnomad EAS exome AF: 0.149

Gnomad FIN exome AF: 0.402

Gnomad NFE exome AF: 0.461

Gnomad OTH exome AF: 0.432

GnomAD4 exome AF: 0.439 AC: 641444 AN: 1461510 Hom.: 144088 Cov.: 47 AF XY: 0.439 AC XY: 319111 AN XY: 727012

African (AFR) AF: 0.426 AC: 14250 AN: 33474

American (AMR) AF: 0.256 AC: 11425 AN: 44714

Ashkenazi Jewish (ASJ) AF: 0.445 AC: 11617 AN: 26132

East Asian (EAS) AF: 0.183 AC: 7269 AN: 39690

South Asian (SAS) AF: 0.388 AC: 33455 AN: 86222

European-Finnish (FIN) AF: 0.404 AC: 21571 AN: 53402

Middle Eastern (MID) AF: 0.476 AC: 2745 AN: 5768

European-Non Finnish (NFE) AF: 0.462 AC: 513206 AN: 1111744

Other (OTH) AF: 0.429 AC: 25906 AN: 60364

GnomAD4 genome AF: 0.423 AC: 64322 AN: 152110 Hom.: 13971 Cov.: 33 AF XY: 0.415 AC XY: 30884 AN XY: 74362

African (AFR) AF: 0.430 AC: 17840 AN: 41488

American (AMR) AF: 0.352 AC: 5379 AN: 15278

Ashkenazi Jewish (ASJ) AF: 0.450 AC: 1562 AN: 3472

East Asian (EAS) AF: 0.162 AC: 839 AN: 5164

South Asian (SAS) AF: 0.373 AC: 1803 AN: 4830

European-Finnish (FIN) AF: 0.382 AC: 4039 AN: 10572

Middle Eastern (MID) AF: 0.435 AC: 127 AN: 292

European-Non Finnish (NFE) AF: 0.464 AC: 31543 AN: 67986

Other (OTH) AF: 0.445 AC: 942 AN: 2116

Alfa AF: 0.446 Hom.: 60218

Bravo AF: 0.420

TwinsUK AF: 0.456 AC: 1692

ALSPAC AF: 0.451 AC: 1737

ESP6500AA AF: 0.434 AC: 1908

ESP6500EA AF: 0.471 AC: 4047

ExAC AF: 0.400 AC: 48614

Asia WGS AF: 0.276 AC: 960 AN: 3478

EpiCase AF: 0.466

EpiControl AF: 0.479

ClinVar

Not reported in ClinVar

Computational scores

Source: dbNSFP v4.9

Name	Calibrated prediction	Score	Prediction
AlphaMissense	Benign	0.044
BayesDel_addAF	Benign	-0.85	T
BayesDel_noAF	Benign	-0.85
CADD	Benign	0.081
DANN	Benign	0.36
DEOGEN2	Benign	0.019	T
Eigen	Benign	-1.4
Eigen_PC	Benign	-1.2
FATHMM_MKL	Benign	0.0011	N
LIST_S2	Benign	0.47	T
MetaRNN	Benign	0.0016	T
MetaSVM	Benign	-0.93	T
MutationAssessor	Benign	-3.1	N
PhyloP100		-0.17
PrimateAI	Uncertain	0.54	T
PROVEAN	Benign	1.4	N
REVEL	Benign	0.073
Sift	Benign	1.0	T
Sift4G	Benign	1.0	T
Polyphen		0.0	B
Vest4		0.012
MPC		0.11
ClinPred		0.0035	T
GERP RS		2.8
PromoterAI		0.0083	Neutral
Varity_R		0.071
gMVP		0.36
Mutation Taster		=100/0	polymorphism (auto)

Splicing

Name	Calibrated prediction	Score	Prediction
SpliceAI score (max)		0.0		Details are displayed if max score is > 0.2

Find out detailed SpliceAI scores and Pangolin per-transcript scores at spliceailookup.broadinstitute.org

Other links and lift over

dbSNP: rs554202; hg19: chr11-75428958; COSMIC: COSV52219937; COSMIC: COSV52219937;