NM_153758.5:c.-149+8325T>A

Variant names:

• chr1-206779403-T-A
• rs6676671
• NM_153758.5:c.-149+8325T>A

Variant summary

Our verdict is Benign. The variant received -12 ACMG points: 0P and 12B. BP4_Strong BA1

The NM_153758.5(IL19):​c.-149+8325T>A variant causes a intron change involving the alteration of a non-conserved nucleotide. The variant allele was found at a frequency of 0.312 in 151,948 control chromosomes in the GnomAD database, including 8,118 homozygotes. In-silico tool predicts a benign outcome for this variant. No clinical diagnostic laboratories have submitted clinical-significance assessments for this variant to ClinVar.

• Frequency: Genomes: 𝑓 0.31 (8118 hom., cov: 30)
• Consequence: IL19 NM_153758.5 intron
• Clinical Significance: Not reported in ClinVar
• Conservation: PhyloP100: 0.471
• Publications: 9 publications found

Genes affected

IL19 (HGNC:5990): (interleukin 19) The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. [provided by RefSeq, Jul 2008]

ACMG classification

Our verdict: Benign. The variant received -12 ACMG points.

• BP4: Computational evidence support a benign effect (BayesDel_noAF=-0.91).
• BA1: GnomAd4 highest subpopulation (NFE) allele frequency at 95% confidence interval = 0.389 is higher than 0.05.

Variant Effect in Transcripts

ACMG analysis was done for transcript: NM_153758.5. You can select a different transcript below to see updated ACMG assignments.

RefSeq Transcripts

Selected	Gene	Transcript	Tags	HGVSc	HGVSp	Effect	Exon Rank	Protein	UniProt
	IL19	NM_153758.5	MANE Select	c.-149+8325T>A		intron	N/A	NP_715639.2
	IL19	NM_001393490.1		c.-149+8573T>A		intron	N/A	NP_001380419.1

Ensembl Transcripts

Selected	Gene	Transcript	Tags	HGVSc	HGVSp	Effect	Exon Rank	Protein	UniProt
	IL19	ENST00000659997.3	MANE Select	c.-149+8325T>A		intron	N/A	ENSP00000499459.2
	IL19	ENST00000656872.2		c.-149+8573T>A		intron	N/A	ENSP00000499487.2
	IL19	ENST00000662320.1		n.67+8573T>A		intron	N/A

Frequencies

GnomAD3 genomes AF: 0.312 AC: 47403 AN: 151830 Hom.: 8116 Cov.: 30

Gnomad AFR AF: 0.242

Gnomad AMI AF: 0.413

Gnomad AMR AF: 0.226

Gnomad ASJ AF: 0.314

Gnomad EAS AF: 0.0314

Gnomad SAS AF: 0.210

Gnomad FIN AF: 0.371

Gnomad MID AF: 0.247

Gnomad NFE AF: 0.393

Gnomad OTH AF: 0.290

We have no GnomAD4 exomes data on this position. Probably position not covered by the project.

GnomAD4 genome AF: 0.312 AC: 47417 AN: 151948 Hom.: 8118 Cov.: 30 AF XY: 0.305 AC XY: 22635 AN XY: 74270

African (AFR) AF: 0.242 AC: 10031 AN: 41448

American (AMR) AF: 0.226 AC: 3448 AN: 15266

Ashkenazi Jewish (ASJ) AF: 0.314 AC: 1090 AN: 3470

East Asian (EAS) AF: 0.0311 AC: 161 AN: 5180

South Asian (SAS) AF: 0.209 AC: 1008 AN: 4820

European-Finnish (FIN) AF: 0.371 AC: 3916 AN: 10546

Middle Eastern (MID) AF: 0.248 AC: 73 AN: 294

European-Non Finnish (NFE) AF: 0.393 AC: 26711 AN: 67910

Other (OTH) AF: 0.287 AC: 604 AN: 2106

Alfa AF: 0.349 Hom.: 1185

Bravo AF: 0.299

Asia WGS AF: 0.124 AC: 432 AN: 3478

ClinVar

Not reported in ClinVar

Computational scores

Source: dbNSFP v4.9

Name	Calibrated prediction	Score	Prediction
BayesDel_noAF	Benign	-0.91
CADD	Benign	2.6
DANN	Benign	0.58
PhyloP100		0.47

Splicing

Find out detailed SpliceAI scores and Pangolin per-transcript scores at spliceailookup.broadinstitute.org

Other links and lift over

dbSNP: rs6676671; hg19: chr1-206952748;