chr1-201648725-C-T
Variant summary
Our verdict is Benign. Variant got -7 ACMG points: 0P and 7B. BP4_ModerateBP7BS2
The NM_001389617.1(NAV1):c.918C>T(p.Gly306Gly) variant causes a synonymous change involving the alteration of a non-conserved nucleotide. The variant allele was found at a frequency of 0.0000106 in 1,414,050 control chromosomes in the GnomAD database, with no homozygous occurrence. In-silico tool predicts a benign outcome for this variant. No clinical diagnostic laboratories have submitted clinical-significance assessments for this variant to ClinVar. Synonymous variant affecting the same amino acid position (i.e. G306G) has been classified as Benign.
Frequency
Consequence
NM_001389617.1 synonymous
Scores
Clinical Significance
Conservation
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ACMG classification
Verdict is Benign. Variant got -7 ACMG points.
Transcripts
RefSeq
Gene | Transcript | HGVSc | HGVSp | Effect | Exon rank | MANE | Protein | UniProt |
---|---|---|---|---|---|---|---|---|
NAV1 | NM_001389617.1 | c.918C>T | p.Gly306Gly | synonymous_variant | Exon 5 of 34 | ENST00000685211.1 | NP_001376546.1 | |
NAV1 | NM_001389616.1 | c.918C>T | p.Gly306Gly | synonymous_variant | Exon 4 of 32 | NP_001376545.1 | ||
NAV1 | NM_001389615.1 | c.918C>T | p.Gly306Gly | synonymous_variant | Exon 5 of 31 | NP_001376544.1 | ||
NAV1 | NM_020443.5 | c.57C>T | p.Gly19Gly | synonymous_variant | Exon 1 of 30 | NP_065176.3 |
Ensembl
Gene | Transcript | HGVSc | HGVSp | Effect | Exon rank | TSL | MANE | Protein | Appris | UniProt |
---|---|---|---|---|---|---|---|---|---|---|
NAV1 | ENST00000685211.1 | c.918C>T | p.Gly306Gly | synonymous_variant | Exon 5 of 34 | NM_001389617.1 | ENSP00000510803.1 | |||
NAV1 | ENST00000367296.8 | c.57C>T | p.Gly19Gly | synonymous_variant | Exon 1 of 30 | 5 | ENSP00000356265.4 | |||
NAV1 | ENST00000367302.5 | c.96C>T | p.Gly32Gly | synonymous_variant | Exon 3 of 30 | 5 | ENSP00000356271.1 |
Frequencies
GnomAD3 genomes AF: 0.0000526 AC: 8AN: 152014Hom.: 0 Cov.: 32
GnomAD4 exome AF: 0.00000555 AC: 7AN: 1262036Hom.: 0 Cov.: 54 AF XY: 0.00000485 AC XY: 3AN XY: 619042
GnomAD4 genome AF: 0.0000526 AC: 8AN: 152014Hom.: 0 Cov.: 32 AF XY: 0.0000404 AC XY: 3AN XY: 74240
ClinVar
Not reported inComputational scores
Source:
Splicing
Find out detailed SpliceAI scores and Pangolin per-transcript scores at