chr11-121577381-T-A

Variant names:

• chr11-121577381-T-A
• rs2070045
• NM_003105.6:c.3561T>A
• SORL1 p.Ser1187Ser

GermlineCancer (beta)

Variant summary

Our verdict is Likely benign.

-2 Likely Benign

-7

-6

-1

0

+5

+6

+9

+10

BenignB

Likely BenignLB

UncertainVUS

Likely PathogenicLP

PathogenicP

The variant received -2 classification points (ACGS-UK Somatic Oncogenicity v2025). O3_ModerateB4_Strong

The NM_003105.6(SORL1):c.3561T>A (p.Ser1187Ser) variant causes a synonymous change involving the alteration of a non-conserved nucleotide. The gene SORL1 is a known oncogene (CancerMine: 1 oncogene citations). The variant allele was found at a cumulative frequency of 0.00000137 (AC=2) in the gnomAD database across 1,457,902 control chromosomes (no homozygotes observed). The grpmax filtering allele frequency (95% CI) is 0.0000003. In-silico predictor (BayesDel (noAF)) classifies this variant as likely benign. Splicing prediction tools (SpliceAI) predict no significant impact on normal splicing. Variant has been reported in ClinVar as Uncertain Significance (no review stars).

• Frequency:
  • Genomes: not found (cov: 33)
  • Exomes 𝑓: 0.0000014 (0 hom.)
• Consequence: SORL1 NM_003105.6 synonymous
• Clinical Significance: Not reported in ClinVar
• Conservation: PhyloP100: -1.19
• Publications: 2 publications found

Genes affected

SORL1 (HGNC:11185): (sortilin related receptor 1) This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded preproprotein is proteolytically processed to generate the mature receptor, which likely plays roles in endocytosis and sorting. Mutations in this gene may be associated with Alzheimer's disease. [provided by RefSeq, Feb 2016]

SORL1 Gene-Disease associations (from GenCC):

• early-onset autosomal dominant Alzheimer disease

  Inheritance: AD Classification: SUPPORTIVE Submitted by: Orphanet

Classification according to ACGS-UK Somatic Oncogenicity v2025

Classification was made for transcript:

Our verdict: Likely_benign. The variant received -2 points.

Apply	Criterion Code & Title / Strength	Strength	Rationale / Clinical Context
	O3Absent or very rare in population		Absent or extremely rare in gnomAD (AC ≤ 2) — O3 moderate; GnomAD: AF = 0.000000, AC = 2 — absent/extremely rare (O3 moderate [+2])
	B4Synonymous/intronic, no splicing impact		Synonymous/intronic variant with confirmed no splicing impact (B4 strong); Synonymous variant — splicing algorithms confirm no impact on splicing (B4 strong [-4])

Variant Effect in Transcripts

Automated classification analysis was done for transcript: NM_003105.6. You can select a different transcript below to see updated classification assignments.

RefSeq Transcripts

Sel.	Gene / Transcript	Tags	HGVSc / HGVSp	Effect	Exon rank	Protein / UniProt
	SORL1 NM_003105.6	MANE Select	c.3561T>A p.Ser1187Ser	synonymous	Exon 25 of 48	Prot: NP_003096.2 UniProt:

SORL1 NM_003105.6

MANE Select

HGVSc / HGVSpc.3561T>Ap.Ser1187Ser

Exon rankExon 25 of 48

synonymous

Prot: NP_003096.2UniProt: Q92673

Ensembl Transcripts

Sel.	Gene / Transcript	Tags	HGVSc / HGVSp	Effect	Exon rank	Protein / UniProt
	SORL1 ENST00000260197.12	TSL:1MANE Select	c.3561T>A p.Ser1187Ser	synonymous	Exon 25 of 48	Prot: ENSP00000260197.6 UniProt:
	SORL1 ENST00000905166.1		c.3561T>A p.Ser1187Ser	synonymous	Exon 25 of 48	Prot: ENSP00000575225.1 UniProt:
	SORL1 ENST00000905167.1		c.3444T>A p.Ser1148Ser	synonymous	Exon 24 of 47	Prot: ENSP00000575226.1 UniProt:

SORL1 ENST00000260197.12

TSL:1MANE Select

HGVSc / HGVSpc.3561T>Ap.Ser1187Ser

Exon rankExon 25 of 48

synonymous

Prot: ENSP00000260197.6UniProt: Q92673

SORL1 ENST00000905166.1

HGVSc / HGVSpc.3561T>Ap.Ser1187Ser

Exon rankExon 25 of 48

synonymous

Prot: ENSP00000575225.1UniProt: A0ACI8RW67

SORL1 ENST00000905167.1

HGVSc / HGVSpc.3444T>Ap.Ser1148Ser

Exon rankExon 24 of 47

synonymous

Prot: ENSP00000575226.1UniProt: A0ACI8S861

Frequencies

Allele frequencies (AF), counts (AC/AN), homozygotes and coverage

Common (AF > 0.05 / Hom > 5)

Rare (AF ≤ 0.0001 / Hom ≤ 1)

Source / population	AF	AC	Hom	AN	Coverage
Global population databases 3 sources Large-scale international reference populations
GnomAD3 genomes	AF:	AC:	Hom:	AN:	Cov:33
GnomAD4 exome	AF: 0.00000137	AC:2	Hom:0	AN:1457902	Cov:33
GnomAD4 genome	AF:	AC:	Hom:	AN:	Cov:33
Local & regional cohorts 1 source Population-specific and national genomic databases
WBBC (Westlake BioBank for Chinese) pilot	AF: 0.000112	AC:1	Hom:0	AN:8960	Cov:

Showing 4 sources

ClinVar

Not reported in ClinVar

Computational Scores

Algorithm	Calibrated pred.	Score	Prediction
AlphaGenome AVI	Benign	0.13
BayesDel_noAF	Benign	-0.59
CADD	Benign	4.4
DANN	Benign	0.82
GPN-Star LLR	N/A	-3.7
GPN-Star score	N/A	3.7
PhyloP100	Benign	-1.2
RBP_binding_hub_radar	N/A	0.0
RBP_regulation_power_radar	N/A	1.7

Showing 9 of 9 scores

Splicing Scores

Algorithm	Calibrated pred.	Score	Prediction
Pangolin (max)	Benign	0.010
SpliceAI score (max)	Benign	0.010	Details are displayed if max score is > 0.2

Showing 2 of 2 scores

Find out detailed SpliceAI scores and Pangolin per-transcript scores at spliceailookup.broadinstitute.org

MaxEntScan Visualizer can be used to analyze the impact of this mutation on the neighboring sequence.

MaveDB functional evidence

MaveDB is a public repository of laboratory assays that test the effect of thousands of variants at once — treat this as supporting research data and interpret it with great caution; it is not a clinical classification.

No MaveDB functional evidence found for this variant.

Other links and lift over

dbSNP: rs2070045;

hg19: chr11-121448090;

ACMG debug oncogenicity

ACGS debug oncogenicity

ACMG debug germline

Submit to ClinVar