Our verdict is Likely benign. The variant received -6 ACMG points: 0P and 6B. BP4_StrongBP6_Moderate
The NM_015271.5(TRIM2):c.1615-7C>G variant causes a splice region, intron change involving the alteration of a non-conserved nucleotide. The variant allele was found at a frequency of 0.000031 in 1,614,064 control chromosomes in the GnomAD database, with no homozygous occurrence. In-silico tool predicts a benign outcome for this variant. 3/3 splice prediction tools predict no significant impact on normal splicing. Variant has been reported in ClinVar as Likely benign (★).
TRIM2 (HGNC:15974): (tripartite motif containing 2) The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Our verdict: Likely_benign. The variant received -6 ACMG points.
BP4
Computational evidence support a benign effect (BayesDel_noAF=-0.85).
BP6
Variant 4-153315825-C-G is Benign according to our data. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars. Variant chr4-153315825-C-G is described in CliVar as Likely_benign. Clinvar id is 541521.Status of the report is criteria_provided_single_submitter, 1 stars.