chr4-89720189-T-G

Variant names:

• chr4-89720189-T-G
• rs356220
• ENST00000673902.1:c.390+9005A>C

GermlineCancer (beta)

Variant summary

Our verdict is Uncertain significance.

0 Uncertain · Cold

-7

-6

-1

0

+5

+6

+9

+10

BenignB

Likely BenignLB

UncertainVUS

Likely PathogenicLP

PathogenicP

The variant received 0 classification points (ACGS-UK Somatic Oncogenicity v2025).

The ENST00000673902.1(SNCA):c.390+9005A>C variant causes a intron change involving the alteration of a non-conserved nucleotide. Note: ENST00000673902.1 is not a MANE Select or MANE Plus Clinical transcript for SNCA; the reported annotation may differ from that of the MANE-designated reference transcript for this gene. The gene SNCA is a tumor suppressor gene (CancerMine: 1 TSG, 2 oncogene citations). The gene SNCA is a known oncogene (CancerMine: 1 TSG, 2 oncogene citations). No reliable population frequency data is available for this variant in the gnomAD database. In-silico predictor (BayesDel (noAF)) classifies this variant as likely benign. No clinical diagnostic laboratories have submitted clinical-significance assessments for this variant to ClinVar.

• Frequency:
  • Genomes: 𝑓 0.0 (0 hom., cov: 30)
  • Failed GnomAD Quality Control
• Consequence: SNCA ENST00000673902.1 intron
• Clinical Significance: Not reported in ClinVar
• Conservation: PhyloP100: -1.66
• Publications: 115 publications found

Genes affected

SNCA (HGNC:11138): (synuclein alpha) Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]

SNCA Gene-Disease associations (from GenCC):

• autosomal dominant Parkinson disease 4

  Inheritance: AD Classification: DEFINITIVE, STRONG Submitted by: Genomics England PanelApp, Ambry Genetics, Labcorp Genetics (formerly Invitae)
• Parkinson disease

  Inheritance: AD Classification: DEFINITIVE Submitted by: Ambry Genetics, ClinGen
• autosomal dominant Parkinson disease 1

  Inheritance: AD Classification: STRONG Submitted by: Genomics England PanelApp
• Lewy body dementia

  Inheritance: AD Classification: STRONG Submitted by: Genomics England PanelApp, Labcorp Genetics (formerly Invitae)
• hereditary late onset Parkinson disease

  Inheritance: AD Classification: SUPPORTIVE Submitted by: Orphanet
• parkinsonian-pyramidal syndrome

  Inheritance: AR Classification: SUPPORTIVE Submitted by: Orphanet

ENSG00000251095 (HGNC:53614): ()

LOC124900602 (HGNC:):

Classification according to ACGS-UK Somatic Oncogenicity v2025

Classification was made for transcript:

Our verdict: Uncertain_significance. The variant received 0 points.

Apply	Criterion Code & Title / Strength	Strength	Rationale / Clinical Context
No applied criteria Uncheck "Show applied only" above to review all 20 criteria.

Variant Effect in Transcripts

Automated classification analysis was done for transcript: ENST00000673902.1. You can select a different transcript below to see updated classification assignments.

RefSeq Transcripts

There are no transcript annotations for this variant.

Ensembl Transcripts

Sel.	Gene / Transcript	Tags	HGVSc / HGVSp	Effect	Exon rank	Protein / UniProt
	SNCA ENST00000673902.1		c.390+9005A>C	intron	Intron 5 of 6	Prot: ENSP00000501102.1 UniProt:
	ENSG00000251095 ENST00000508021.5	TSL:4	n.448-6195T>G	intron	Intron 4 of 4	Prot:
	ENSG00000251095 ENST00000659878.1		n.480-6195T>G	intron	Intron 2 of 2	Prot:

SNCA ENST00000673902.1

HGVSc / HGVSpc.390+9005A>C

Exon rankIntron 5 of 6

intron

Prot: ENSP00000501102.1UniProt: A0A669KB41

ENSG00000251095 ENST00000508021.5

TSL:4

HGVSc / HGVSpn.448-6195T>G

Exon rankIntron 4 of 4

intron

Prot:

ENSG00000251095 ENST00000659878.1

HGVSc / HGVSpn.480-6195T>G

Exon rankIntron 2 of 2

intron

Prot:

Frequencies

Allele frequencies (AF), counts (AC/AN), homozygotes and coverage

Common (AF > 0.05 / Hom > 5)

Rare (AF ≤ 0.0001 / Hom ≤ 1)

Source / population	AF	AC	Hom	AN	Coverage
Global population databases 4 sources Large-scale international reference populations
GnomAD3 genomes	AF: 0.00	AC:0	Hom:0	AN:150494	Cov:30
GnomAD4 exome	AF:	AC:	Hom:	AN:	Cov:0
GnomAD4 genome Warning	AF: 0.00	AC:0	Hom:0	AN:150494	Cov:30
ALFA (dbGaP/dbSNP Allele Frequency Aggregator)	AF: 0.00	AC:0	Hom:132389	AN:720348	Cov:

Showing 4 sources

ClinVar

Not reported in ClinVar

Computational Scores

Algorithm	Calibrated pred.	Score	Prediction
AlphaGenome AVI	Benign	3.2
BayesDel_noAF	Benign	-0.86
CADD	Benign	0.16
DANN	Benign	0.69
GPN-Star LLR	N/A	1.3
GPN-Star score	N/A	-1.3
PhyloP100	Benign	-1.7

Showing 7 of 7 scores

Splicing Scores

Algorithm	Calibrated pred.	Score	Prediction
Pangolin (max)	Benign	0.0

Showing 1 of 1 scores

Find out detailed SpliceAI scores and Pangolin per-transcript scores at spliceailookup.broadinstitute.org

MaxEntScan Visualizer can be used to analyze the impact of this mutation on the neighboring sequence.

MaveDB functional evidence

MaveDB is a public repository of laboratory assays that test the effect of thousands of variants at once — treat this as supporting research data and interpret it with great caution; it is not a clinical classification.

No MaveDB functional evidence found for this variant.

Other links and lift over

dbSNP: rs356220;

hg19: chr4-90641340;

ACMG debug oncogenicity

ACGS debug oncogenicity

ACMG debug germline

Submit to ClinVar