rs10903034

Positions:

• chr1-24154415-C-T

Variant summary

Our verdict is Benign. Variant got -12 ACMG points: 0P and 12B. BP4_Strong BA1

The NM_170743.4(IFNLR1):​c.*2715G>A variant causes a 3 prime UTR change involving the alteration of a non-conserved nucleotide. The variant allele was found at a frequency of 0.539 in 152,096 control chromosomes in the GnomAD database, including 22,410 homozygotes. In-silico tool predicts a benign outcome for this variant. No clinical diagnostic laboratories have submitted clinical-significance assessments for this variant to ClinVar.

• Frequency:
  • Genomes: 𝑓 0.54 (22405 hom., cov: 33)
  • Exomes 𝑓: 0.67 (5 hom.)
• Consequence: IFNLR1 NM_170743.4 3_prime_UTR
• Clinical Significance: Not reported in ClinVar
• Conservation: PhyloP100: -2.31

Genes affected

IFNLR1 (HGNC:18584): (interferon lambda receptor 1) The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

LOC124903879 (HGNC:):

ACMG classification

Verdict is Benign. Variant got -12 ACMG points.

• BP4: Computational evidence support a benign effect (BayesDel_noAF=-0.93).
• BA1: GnomAd4 highest subpopulation (AMR) allele frequency at 95% confidence interval = 0.562 is higher than 0.05.

Transcripts

RefSeq

Gene	Transcript	HGVSc	HGVSp	Effect	#exon/exons	MANE	UniProt
IFNLR1	NM_170743.4	c.*2715G>A		3_prime_UTR_variant	7/7	ENST00000327535.6
LOC124903879	XR_007065544.1	n.307-597C>T		intron_variant, non_coding_transcript_variant

Ensembl

Gene	Transcript	HGVSc	HGVSp	Effect	#exon/exons	TSL	MANE	Appris	UniProt
IFNLR1	ENST00000327535.6	c.*2715G>A		3_prime_UTR_variant	7/7	1	NM_170743.4	P1

Frequencies

GnomAD3 genomes AF: 0.539 AC: 81968 AN: 151954 Hom.: 22392 Cov.: 33

Gnomad AFR AF: 0.514

Gnomad AMI AF: 0.519

Gnomad AMR AF: 0.572

Gnomad ASJ AF: 0.554

Gnomad EAS AF: 0.304

Gnomad SAS AF: 0.464

Gnomad FIN AF: 0.670

Gnomad MID AF: 0.544

Gnomad NFE AF: 0.549

Gnomad OTH AF: 0.567

GnomAD4 exome AF: 0.667 AC: 16 AN: 24 Hom.: 5 Cov.: 0 AF XY: 0.625 AC XY: 10 AN XY: 16

Gnomad4 FIN exome AF: 0.643

Gnomad4 NFE exome AF: 0.750

Gnomad4 OTH exome AF: 0.500

GnomAD4 genome AF: 0.539 AC: 82021 AN: 152072 Hom.: 22405 Cov.: 33 AF XY: 0.542 AC XY: 40303 AN XY: 74356

Gnomad4 AFR AF: 0.513

Gnomad4 AMR AF: 0.572

Gnomad4 ASJ AF: 0.554

Gnomad4 EAS AF: 0.305

Gnomad4 SAS AF: 0.463

Gnomad4 FIN AF: 0.670

Gnomad4 NFE AF: 0.549

Gnomad4 OTH AF: 0.569

Alfa AF: 0.548 Hom.: 30193

Bravo AF: 0.531

Asia WGS AF: 0.421 AC: 1461 AN: 3478

ClinVar

Not reported in ClinVar

Computational scores

Source: dbNSFP v4.3

Name	Calibrated prediction	Score	Prediction
BayesDel_noAF	Benign	-0.93
CADD	Benign	0.11
DANN	Benign	0.66

Splicing

Name	Calibrated prediction	Score	Prediction
SpliceAI score (max)		0.0		Details are displayed if max score is > 0.2

Find out detailed SpliceAI scores and Pangolin per-transcript scores at spliceailookup.broadinstitute.org

Publications

LitVar

Other links and lift over

dbSNP: rs10903034; hg19: chr1-24480905;