rs587780799

Variant names:

• chr17-43092588-T-A
• rs587780799
• NM_007294.4:c.2943A>T

Your query was ambiguous. Multiple possible variants found:

• chr17-43092588-T-A
• chr17-43092588-T-C

Variant summary

Our verdict is Benign. The variant received -12 ACMG points: 0P and 12B. BP4_Strong BP6_Very_Strong

The NM_007294.4(BRCA1):​c.2943A>T​(p.Pro981Pro) variant causes a synonymous change involving the alteration of a non-conserved nucleotide. The variant allele was found at a frequency of 0.00000372 in 1,613,948 control chromosomes in the GnomAD database, with no homozygous occurrence. In-silico tool predicts a benign outcome for this variant. Variant has been reported in ClinVar as Likely benign (★★★). Synonymous variant affecting the same amino acid position (i.e. P981P) has been classified as Likely benign.

• Frequency:
  • Genomes: 𝑓 0.0000066 (0 hom., cov: 32)
  • Exomes 𝑓: 0.0000034 (0 hom.)
• Consequence: BRCA1 NM_007294.4 synonymous
• Clinical Significance: Likely benign reviewed by expert panel B:5
• Conservation: PhyloP100: 0.542
• Publications: 1 publications found

Genes affected

BRCA1 (HGNC:1100): (BRCA1 DNA repair associated) This gene encodes a 190 kD nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The BRCA1 gene contains 22 exons spanning about 110 kb of DNA. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2020]

BRCA1 Gene-Disease associations (from GenCC):

• breast-ovarian cancer, familial, susceptibility to, 1

  Inheritance: AD Classification: DEFINITIVE, STRONG Submitted by: Ambry Genetics, ClinGen, Labcorp Genetics (formerly Invitae), Genomics England PanelApp
• Fanconi anemia, complementation group S

  Inheritance: AR Classification: DEFINITIVE, STRONG, MODERATE, LIMITED Submitted by: G2P, Labcorp Genetics (formerly Invitae), ClinGen, Ambry Genetics
• pancreatic cancer, susceptibility to, 4

  Inheritance: AD Classification: MODERATE Submitted by: Genomics England PanelApp
• hereditary breast ovarian cancer syndrome

  Inheritance: AD Classification: SUPPORTIVE Submitted by: Orphanet
• Fanconi anemia

  Inheritance: AR Classification: SUPPORTIVE Submitted by: Orphanet

ACMG classification

Our verdict: Benign. The variant received -12 ACMG points.

• BP4: Computational evidence support a benign effect (BayesDel_noAF=-0.86).
• BP6: Variant 17-43092588-T-A is Benign according to our data. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars. Variant chr17-43092588-T-A is described in CliVar as Likely_benign. Clinvar id is 136083.Status of the report is reviewed_by_expert_panel, 3 stars.

Transcripts

RefSeq

Gene	Transcript	HGVSc	HGVSp	Effect	Exon rank	MANE	Protein	UniProt
BRCA1	NM_007294.4	c.2943A>T	p.Pro981Pro	synonymous_variant	Exon 10 of 23	ENST00000357654.9	NP_009225.1

Ensembl

Gene	Transcript	HGVSc	HGVSp	Effect	Exon rank	TSL	MANE	Protein	Appris	UniProt
BRCA1	ENST00000357654.9	c.2943A>T	p.Pro981Pro	synonymous_variant	Exon 10 of 23	1	NM_007294.4	ENSP00000350283.3

Frequencies

GnomAD3 genomes AF: 0.00000657 AC: 1 AN: 152132 Hom.: 0 Cov.: 32

Gnomad AFR AF: 0.00

Gnomad AMI AF: 0.00

Gnomad AMR AF: 0.00

Gnomad ASJ AF: 0.00

Gnomad EAS AF: 0.00

Gnomad SAS AF: 0.00

Gnomad FIN AF: 0.00

Gnomad MID AF: 0.00

Gnomad NFE AF: 0.0000147

Gnomad OTH AF: 0.00

GnomAD4 exome AF: 0.00000342 AC: 5 AN: 1461816 Hom.: 0 Cov.: 51 AF XY: 0.00000275 AC XY: 2 AN XY: 727204

African (AFR) AF: 0.00 AC: 0 AN: 33480

American (AMR) AF: 0.00 AC: 0 AN: 44724

Ashkenazi Jewish (ASJ) AF: 0.00 AC: 0 AN: 26132

East Asian (EAS) AF: 0.00 AC: 0 AN: 39684

South Asian (SAS) AF: 0.00 AC: 0 AN: 86254

European-Finnish (FIN) AF: 0.00 AC: 0 AN: 53398

Middle Eastern (MID) AF: 0.00 AC: 0 AN: 5768

European-Non Finnish (NFE) AF: 0.00000360 AC: 4 AN: 1111982

Other (OTH) AF: 0.0000166 AC: 1 AN: 60394

GnomAD4 genome AF: 0.00000657 AC: 1 AN: 152132 Hom.: 0 Cov.: 32 AF XY: 0.0000135 AC XY: 1 AN XY: 74312

African (AFR) AF: 0.00 AC: 0 AN: 41434

American (AMR) AF: 0.00 AC: 0 AN: 15260

Ashkenazi Jewish (ASJ) AF: 0.00 AC: 0 AN: 3472

East Asian (EAS) AF: 0.00 AC: 0 AN: 5194

South Asian (SAS) AF: 0.00 AC: 0 AN: 4822

European-Finnish (FIN) AF: 0.00 AC: 0 AN: 10614

Middle Eastern (MID) AF: 0.00 AC: 0 AN: 316

European-Non Finnish (NFE) AF: 0.0000147 AC: 1 AN: 68020

Other (OTH) AF: 0.00 AC: 0 AN: 2088

Alfa AF: 0.00 Hom.: 0

Bravo AF: 0.00000378

ClinVar

Significance: Likely benign

Submissions summary: Benign:5

Revision: reviewed by expert panel

Submissions by phenotype

Breast-ovarian cancer, familial, susceptibility to, 1 Benign:2

Jun 29, 2017

Evidence-based Network for the Interpretation of Germline Mutant Alleles (ENIGMA)

Significance: Likely benign

Review Status: reviewed by expert panel

Collection Method: curation

Synonymous substitution variant, with low bioinformatic likelihood to result in a splicing aberration (Splicing prior probability 0.02; http://priors.hci.utah.edu/PRIORS/). -

Dec 13, 2023

All of Us Research Program, National Institutes of Health

Significance: Likely benign

Review Status: criteria provided, single submitter

Collection Method: clinical testing

- -

not specified Benign:1

Oct 09, 2017

GeneDx

Significance: Likely benign

Review Status: criteria provided, single submitter

Collection Method: clinical testing

This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease. -

Hereditary cancer-predisposing syndrome Benign:1

Jul 11, 2020

Ambry Genetics

Significance: Likely benign

Review Status: criteria provided, single submitter

Collection Method: clinical testing

This alteration is classified as likely benign based on a combination of the following: seen in unaffected individuals, population frequency, intact protein function, lack of segregation with disease, co-occurrence, RNA analysis, in silico models, amino acid conservation, lack of disease association in case-control studies, and/or the mechanism of disease or impacted region is inconsistent with a known cause of pathogenicity. -

Hereditary breast ovarian cancer syndrome Benign:1

Jan 21, 2025

Labcorp Genetics (formerly Invitae), Labcorp

Significance: Likely benign

Review Status: criteria provided, single submitter

Collection Method: clinical testing

- -

Computational scores

Source: dbNSFP v4.3

Name	Calibrated prediction	Score	Prediction
BayesDel_noAF	Benign	-0.86
CADD	Benign	4.9
DANN	Benign	0.45
PhyloP100		0.54

Splicing

Name	Calibrated prediction	Score	Prediction
SpliceAI score (max)		0.0		Details are displayed if max score is > 0.2

Find out detailed SpliceAI scores and Pangolin per-transcript scores at spliceailookup.broadinstitute.org

Other links and lift over

dbSNP: rs587780799; hg19: chr17-41244605;