rs637186
Variant summary
Our verdict is Benign. Variant got -12 ACMG points: 0P and 12B. BP4_StrongBA1
The NM_014207.4(CD5):āc.1382A>Gā(p.His461Arg) variant causes a missense change involving the alteration of a non-conserved nucleotide. The variant allele was found at a frequency of 0.922 in 1,613,890 control chromosomes in the GnomAD database, including 686,879 homozygotes. In-silico tool predicts a benign outcome for this variant. 14/20 in silico tools predict a benign outcome for this variant. No clinical diagnostic laboratories have submitted clinical-significance assessments for this variant to ClinVar. Another nucleotide change resulting in the same amino acid substitution has been previously reported as Likely benign in UniProt.
Frequency
Consequence
NM_014207.4 missense
Scores
Clinical Significance
Conservation
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ACMG classification
Verdict is Benign. Variant got -12 ACMG points.
Transcripts
RefSeq
Ensembl
Frequencies
GnomAD3 genomes AF: 0.941 AC: 143142AN: 152136Hom.: 67420 Cov.: 32
GnomAD3 exomes AF: 0.937 AC: 235418AN: 251230Hom.: 110437 AF XY: 0.934 AC XY: 126871AN XY: 135794
GnomAD4 exome AF: 0.920 AC: 1345114AN: 1461636Hom.: 619403 Cov.: 48 AF XY: 0.921 AC XY: 669547AN XY: 727120
GnomAD4 genome AF: 0.941 AC: 143257AN: 152254Hom.: 67476 Cov.: 32 AF XY: 0.942 AC XY: 70118AN XY: 74434
ClinVar
Not reported inComputational scores
Source:
Splicing
Find out detailed SpliceAI scores and Pangolin per-transcript scores at