rs7162113

Variant summary

Our verdict is Benign. Variant got -12 ACMG points: 0P and 12B. BP4_StrongBA1

The ENST00000355300.7(LINGO1):​c.7-6985T>C variant causes a intron change involving the alteration of a non-conserved nucleotide. The variant allele was found at a frequency of 0.838 in 152,212 control chromosomes in the GnomAD database, including 53,791 homozygotes. In-silico tool predicts a benign outcome for this variant. No clinical diagnostic laboratories have submitted clinical-significance assessments for this variant to ClinVar.

Frequency

Genomes: 𝑓 0.84 ( 53791 hom., cov: 33)

Consequence

LINGO1
ENST00000355300.7 intron

Scores

2

Clinical Significance

Not reported in ClinVar

Conservation

PhyloP100: 0.145
Variant links:
Genes affected
LINGO1 (HGNC:21205): (leucine rich repeat and Ig domain containing 1) Predicted to enable epidermal growth factor receptor binding activity. Predicted to act upstream of or within generation of neurons and protein kinase B signaling. Predicted to be located in plasma membrane. Predicted to be active in extracellular matrix and extracellular space. Implicated in autosomal recessive non-syndromic intellectual disability and glaucoma. [provided by Alliance of Genome Resources, Apr 2022]

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ACMG classification

Classification made for transcript

Verdict is Benign. Variant got -12 ACMG points.

BP4
Computational evidence support a benign effect (BayesDel_noAF=-0.91).
BA1
GnomAd4 highest subpopulation (AFR) allele frequency at 95% confidence interval = 0.937 is higher than 0.05.

Transcripts

RefSeq

Gene Transcript HGVSc HGVSp Effect #exon/exons MANE Protein UniProt
LINGO1NM_032808.7 linkuse as main transcriptc.7-6985T>C intron_variant ENST00000355300.7 NP_116197.4
LOC105370906XR_001751806.2 linkuse as main transcriptn.689-7400A>G intron_variant, non_coding_transcript_variant

Ensembl

Gene Transcript HGVSc HGVSp Effect #exon/exons TSL MANE Protein Appris UniProt
LINGO1ENST00000355300.7 linkuse as main transcriptc.7-6985T>C intron_variant 1 NM_032808.7 ENSP00000347451 A1Q96FE5-1

Frequencies

GnomAD3 genomes
AF:
0.837
AC:
127361
AN:
152094
Hom.:
53730
Cov.:
33
show subpopulations
Gnomad AFR
AF:
0.945
Gnomad AMI
AF:
0.713
Gnomad AMR
AF:
0.836
Gnomad ASJ
AF:
0.729
Gnomad EAS
AF:
0.866
Gnomad SAS
AF:
0.865
Gnomad FIN
AF:
0.832
Gnomad MID
AF:
0.741
Gnomad NFE
AF:
0.777
Gnomad OTH
AF:
0.824
We have no GnomAD4 exomes data on this position. Probably position not covered by the project.
GnomAD4 genome
AF:
0.838
AC:
127482
AN:
152212
Hom.:
53791
Cov.:
33
AF XY:
0.842
AC XY:
62693
AN XY:
74424
show subpopulations
Gnomad4 AFR
AF:
0.945
Gnomad4 AMR
AF:
0.836
Gnomad4 ASJ
AF:
0.729
Gnomad4 EAS
AF:
0.866
Gnomad4 SAS
AF:
0.864
Gnomad4 FIN
AF:
0.832
Gnomad4 NFE
AF:
0.777
Gnomad4 OTH
AF:
0.821
Alfa
AF:
0.788
Hom.:
56292
Bravo
AF:
0.841
Asia WGS
AF:
0.832
AC:
2891
AN:
3478

ClinVar

Not reported in ClinVar

Computational scores

Source: dbNSFP v4.3

Name
Calibrated prediction
Score
Prediction
BayesDel_noAF
Benign
-0.91
CADD
Benign
4.3
DANN
Benign
0.64

Splicing

Name
Calibrated prediction
Score
Prediction
SpliceAI score (max)
0.0
Details are displayed if max score is > 0.2

Find out detailed SpliceAI scores and Pangolin per-transcript scores at spliceailookup.broadinstitute.org

Publications

LitVar

Below is the list of publications found by LitVar. It may be empty.

Other links and lift over

dbSNP: rs7162113; hg19: chr15-77915227; API